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Science China(Life Sciences) 2024年第10期67卷 2120-2131页

作者： Jingjing Ruan Xiaoxiao Yu Huixia Xu Wenrui Cui Kaiye Zhang Chenyang Liu Wenlong Sun Xiaodan Huang Lei An Yue Zhang The Children's Hospital National Clinical Research Center for Child HealthZhejiang University School of MedicineLiangzhu LaboratoryHangzhou 310000China Liangzhu Laboratory Zhejiang University School of MedicineHangzhou 311121China Department of Thoracic and Cardiovascular Surgery Huaihe Hospital of Henan UniversityHenan UniversityKaifeng 475000China Translational Medicine Center Huaihe Hospital of Henan UniversityHenan UniversityKaifeng 475000China Eye Center The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China

Suppressor tRNAs are engineered or naturally occurring transfer RNA molecules that have shown promise in gene therapy for diseases caused by nonsense mutations,which result in premature termination codons(PTCs)in coding sequence,leading to truncated,often nonfunctional *** t RNAs can recognize and pair with these PTCs,allowing the ribosome to continue translation and produce a full-length *** review introduces the mechanism and development of suppressor t RNAs,compares suppressor tRNAs with other readthrough therapies,discusses their potential for clinical therapy,limitations,and *** also summarize the applications of suppressor tRNAs in both in vitro and in vivo,offering new insights into the research and treatment of nonsense mutation diseases.

关键词： suppressor tRNA PTC nonsense mutation readthrough gene therapy

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Cloning and expression of the Chinese wheat mosaic virus RNA2 coat protein read-through and 19 ku cysteine-rich domains and localization of these proteins

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Chinese Science Bulletin 2002年第12期47卷 1019-1023页

作者： XU Lei CHEN Jianping YE Rong ZHAO Xiuyun YU Shanqing Microbiology Department Fudan UniversityShanghai 200433China Virology Laboratory Zhejiang Academy of Agricultural SciencesHangzhou 200433China

The 5’-terminal (RTn) and 3’-terminal (RTc) halves of the coat protein readthrough domain and the 19 ku cysteine-rich protein of Chinese wheat mosaic virus (CWMV) were amplified by RT-PCR, cloned and expressed in E. coll. Antisera and monoclonal antibodies against these proteins were prepared by immunising these purified proteins to mice. Detection of RTn, RTc and 19 ku proteins in CWMV infected wheat sap and leaf tissue indicated that the RTn and RTc proteins were distributed on the surface of virus particles whereas the 19 ku protein was in the cytoplasm of the infected wheat cells.

关键词： Chinese wheat mosaic virus coat protein readthrough domain cysteine-rich domain prokaryotic expression localisation.

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Application of topical gentamicin-a new era in the treatment of genodermatosis

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World Journal of Pediatrics 2021年第6期17卷 568-575页

作者： Shan Wang Zhou Yang Ying Liu Mu-Tong Zhao Juan Zhao Huan Zhang Zong-Yang Liu Xiao-Ling Wang Lin Ma Yong-Hong Yang Department of Dermatology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthNo.56 South Li Shi RoadXi Cheng DistrictBeijing 100045China Department of Pharmacy.Beijing Children's Hospital Capital Medical UniversityNational Center for Children's HealthNo.56 South Li Shi RoadXi Cheng DistrictBeijing 100045China China National Clinical Research Center for Respiratory Diseases Department of Respiratory MedicineBeijing Children's HospitalCapital Medical UniversityNational Center for Children’s HealthNo.56 South Li Shi RoadXi Cheng DistrictBeijing 100045China

Background The clinical use of gentamicin always lies in its antimicrobial activity in the past as an aminoglycoside ***,in the past decade,there were considerable interests in therapeutic approaches in treating hereditary *** of the genodermatosis is caused by nonsense mutations that create premature termination codons and lead to the production of truncated or non-functional *** could induce readthrough of nonsense mutations and enable the synthesis of full-length *** focus on previous publications on topical application of gentamicin and review its utility in genetic skin *** sources We search the MEDLINE through PubMed,EMBASE databases,and the Clinical Trials Registry Platform from January 1960 to July 2020 using the key search terms"gentamicin,topical gentamicin,genodermatosis,genetic skin diseases".Results The application of gentamicin in genodermatosis yielded promising results,both in vivo and in vitro,including Nagashima-type palmoplantar keratosis,epidermolysis bullosa,Hailey-Hailey disease,hereditary hypotrichosis simplex of the scalp,*** Topical gentamicin is a potential treatment option for genodermatosis caused by nonsense mutation.

关键词： Epidermolysis bullosa Gentamicin Nagashima-type palmoplantar keratosis Nonsense mutation readthrough

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