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Animal Nutrition 2021年第3期7卷 823-828页

作者： Zhen Luo Jianbo Yao Jianxiong Xu School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai Key Laboratory of Veterinary BiotechnologyShanghaiChina Division of Animal and Nutritional Sciences West Virginia UniversityMorgantownWVUSA

Significant porcine embryonic loss occurs during conceptus morphological elongation and attachment from d 10 to 20 of pregnancy,which directly decreases the reproductive efficiency of sows.A successful establishment of pregnancy mainly depends on the endometrium receptivity,embryo quality,and utero-placental microenvironment,which requires complex cross-talk between the conceptus and *** understanding of the molecular mechanism regulating the uterine-conceptus communication during porcine conceptus elongation and attachment has developed in the past *** oxygen and nitrogen species,which are intracellular reactive metabolites that regulate cell fate decisions and alter their biological functions,have recently reportedly been involved in porcine conceptus elongation and *** mini-review will mainly focus on the recent researches about the role of reactive ox-ygen and nitrogen species in regulating porcine embryo development during the pre-implantation period.

关键词： reactive oxygen and nitrogen species Pre-implantation Porcine Embryo development

Recent advances and applications of single atom catalysts based electrochemical sensors

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Nano Research 2024年第4期17卷 2994-3013页

作者： Mingyue Wang Mingfu Ye Jieyue Wang Yong Xu Zhendong Wang Xinyue Tong Xinya Han Kui Zhang Wenhai Wang Konglin Wu Xianwen Wei Institute of Clean Energy and Advanced Nanocatalysis(iClean) School of Chemistry and Chemical EngineeringAnhui University of TechnologyMaanshan 243002China School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China Anhui International Research Center of Energy materials green manufacturing and biotechnology School of Chemistry and Chemical EngineeringAnhui University of TechnologyMaanshan 243002China Carbon Cycle and Emission Control Research Center Low-Carbon Research InstituteAnhui University of TechnologyMaanshan 243002China

Single atom catalysts(SACs)have attracted considerable attention due to their unique structures and excellent catalytic performance,especially in the area of catalysis science and energy conversion and *** recent years,SACs have emerged as a new type of sensing material for constructing electrochemical sensors(ECSs),presenting excellent sensitivity,selectivity,and ***,we review the recent advances of SACs in electrochemical sensing and discuss the status quo of current SAC-based ***,the fundamentals of SAC-based ECSs are outlined,including the involved central metal atoms and various supports of SACs in this field,the detection mechanisms,and improving strategies of SAC-based ***,the important applications of SAC-based ECSs are listed and classified,covering the detection of reactive oxygen and nitrogen species,environmental pollutants,disease biomarkers,and ***,based on abundant reported cases,the current conundrums of SAC-based ECSs are summarized,and the prediction of their future developing trends is also put forward.

关键词： single atom catalysts(SACs) electrochemical sensors(ECSs) reactive oxygen and nitrogen species environmental pollutants disease biomarkers pharmaceuticals

Quality enhancement and microbial reduction of mung bean(Vigna radiata)sprouts by non-thermal plasma pretreatment of seeds

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Plasma Science and Technology 2022年第4期24卷 164-176页

作者： Dongjie CUI Xiaoxia HU Yue YIN Yupan ZHU Jie ZHUANG Xiaojie WANG Ruonan MA Zhen JIAO Henan Key Laboratory of Ion-Beam Bioengineering School of Agricultural SciencesZhengzhou UniversityZhengzhou 450052People's Republic of China Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of SciencesSuzhou 215163People's Republic of China School of Life Sciences and Basic Medicine Xinxiang UniversityXinxiang 453003People's Republic of China

Mung bean(Vigna radiata)sprouts are widely consumed worldwide due to their high nutritional ***,the low yield and microbial contamination of mung bean sprouts seriously reduces their economic *** study investigates the effects of non-thermal plasma on the quality and microbial reduction of mung bean sprouts by pretreatment of seeds in water for different times(0,1,3 and 6 min).The quality results showed that short-time plasma treatment(1 and 3 min)promoted seed germination and seedling growth,whereas long-time plasma treatment(6 min)had inhibitory *** also had a similar dose effects on the total flavonoid and phenolic contents of mung bean *** microbiological results showed that plasma treatment achieved a reduction of native microorganisms ranging from 0.54 to 7.09 log for fungi and 0.29 to 6.80 log for bacteria at 96 h ***,plasma treatment could also efficiently inactivate artificially inoculated Salmonella typhimurium(1.83–6.22 log)and yeast(0.53–3.19 log)on mung bean *** results of seed coat permeability tests and scanning electron microscopy showed that plasma could damage the seed coat structure,consequently increasing the electrical conductivity of mung bean *** physicochemical analysis of plasma-treated water showed that plasma generated various long-and short-lived active species[nitric oxide radicals(NO·),hydroxyl radicals(·OH),singlet oxygen(1O2),hydrogen peroxide(H_(2)O_(2)),nitrate(NO_(3)^(-)),and nitrite(NO_(2)^(-))]in water,thus the oxidizability,acidity and conductivity of plasma-treated water were all increased in a treatment timedependent *** result for mimicked chemical mixtures confirmed the synergistic effect of activity of H_(2)O_(2),NO_(3)^(-)and NO_(2)^(-)on bacterial inactivation and plant growth *** together,these results imply that plasma pretreatment of mung bean seeds in water with moderate oxidizability and acidity is an effective method to improve the y

关键词： non-thermal plasma mung bean sprout quality microbial reduction reactive oxygen and nitrogen species

Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection

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Nano Research 2023年第7期16卷 9752-9759页

作者： Yuxing Jiang Hongtao Rong Yifan Wang Shange Liu Peng Xu Zhen Luo Lamei Guo Tao Zhu(✉) Hongpan Rong Dingsheng Wang Jiatao Zhang Yu Yi Hao Wang Tianjin Medical University General Hospital Tianjin 300052China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190China Beijing Key Laboratory of Construction-Tailorable Advanced Functional Materials and Green Applications Key Laboratory of Medical Molecule Science and Pharmaceutics EngineeringMinistry of Industry and Information TechnologySchool of Materials Science&EngineeringSchool of Chemistry and Chemical EngineeringInstitute of Engineering MedicineBeijing Institute of TechnologyBeijing 100081China Department of Chemistry Tsinghua UniversityBeijing 100084China University of Chinese Academy of Sciences Beijing 100049China

Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury(SCI).Antioxidant therapies that reduce the reactive oxygen and nitrogen species(RONS)overgeneration and inflammation are proved promising for improving the ***,efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains ***,a single-atom cobalt nanozyme(Co-SAzyme)with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of *** SAzymes featuring different single metal-N sites(e.g.,Mn,Fe,Co,Ni,and Cu),this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide(H_(2)O_(2)),superoxide anion(O_(2)·^(-)),hydroxyl radical(·OH),nitric oxide(·NO),and peroxynitrite(ONOO^(-))that overexpressed in the early stage of *** porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in *** vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative *** addition,the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model.

关键词： single-atom catalysis spinal cord injury reactive oxygen and nitrogen species anti-inflammation neuroprotection

Reversible fluorescent probes for chemical and biological redox process

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Chinese Chemical Letters 2017年第10期28卷 1929-1934页

作者： Biao Li Zhaoshuai He Hanxin Zhou Han Zhang Tanyu Cheng Key Laboratory of Resource Chemistry of Ministry of Education Key Laboratory of Rare Earth Functional Materials Department of Chemistry Shanghai Normal University Shanghai 200234 China

Oxidation and reduction are important chemical and biological processes. The redox state is related with physical functions and health. Thus, it is meaningful to develop tools for study the redox *** is a powerful method to connecting the microcosm and macrocosm. In this review, we discuss the recent progress of reversible fluorescent probes for chemical and biological redox process according to different active centers.

关键词： Redox probe Fluorescent probe Reversible probe reactive oxygen and nitrogen species Quinone

Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney

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Bioactive Materials 2023年第4期22卷 141-167页

作者： Qiaohui Chen Yayun Nan Yuqi Yang Zuoxiu Xiao Min Liu Jia Huang Yuting Xiang Xingyu Long Tianjiao Zhao Xiaoyuan Wang Qiong Huang Kelong Ai Xiangya School of Pharmaceutical Sciences Central South UniversityChangshaHunan410078PR China Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha410078PR China Department of Pharmacy Xiangya HospitalCentral South UniversityChangshaHunan410008PR China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan410008PR China Geriatric Medical Center People’s Hospital of Ningxia Hui Autonomous RegionYinchuanNingxia750002PR China

Currently,there are no clinical drugs available to treat acute kidney injury(AKI).Given the high prevalence and high mortality rate of AKI,the development of drugs to effectively treat AKI is a huge unmet medical need and a research *** existing evidence fully demonstrates that reactive oxygen and nitrogen species(RONS)burst at the AKI site is a major contributor to AKI progression,the heterogeneity,complexity,and unique physiological structure of the kidney make most antioxidant and anti-inflammatory small molecule drugs ineffective because of the lack of kidney targeting and side ***,nanodrugs with intrinsic kidney targeting through the control of size,shape,and surface properties have opened exciting prospects for the treatment of *** antioxidant nanodrugs have emerged to address the limitations of current AKI *** this review,we systematically summarized for the first time about the emerging nanodrugs that exploit the pathological and physiological features of the kidney to overcome the limitations of traditional small-molecule drugs to achieve high AKI ***,we analyzed the pathological structural characteristics of AKI and the main pathological mechanism of AKI:hypoxia,harmful substance accumulation-induced RONS burst at the renal site despite the multifactorial initiation and heterogeneity of ***,we introduced the strategies used to improve renal targeting and reviewed advances of nanodrugs for AKI:nano-RONS-sacrificial agents,antioxidant nanozymes,and nanocarriers for antioxidants and anti-inflammatory *** nanodrugs have demonstrated excellent therapeutic effects,such as greatly reducing oxidative stress damage,restoring renal function,and low side ***,we discussed the challenges and future directions for translating nanodrugs into clinical AKI treatment.

关键词： reactive oxygen and nitrogen species Acute kidney injury Nanomaterials Antioxidant therapy Renal physiology

Effect of low-temperature plasma on the degradation of omethoate residue and quality of apple and spinach

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Plasma Science and Technology 2018年第4期20卷 24-30页

作者：石兴民刘进仁许桂敏吴月明高菱鸽李晓艳杨阳张冠军 School of Public Health Medical Science Center Xi'an Jiaotong University Xi'an 710061 People's Republic of China State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi'an Jiaotong University Xi'an 710049 People's Republic of China College of Nursing Xi'an SiYuan University Xi'an 710038 People's Republic of China

Dielectric barrier corona discharge was developed to generate low-temperature plasma(LTP) to treat apple and spinach samples contaminated with omethoate. Experimental results showed that,after 20 min exposure, the degradation rate of omethoate residue in apple and spinach was(94.55± 0.01)% and(95.55 ± 0.01)%, respectively. When the treatment time was shorter than 20 min,the contents of moisture, vitamin C and beta-carotene were not affected by LTP. Exploration of related mechanisms suggested that LTP might destroy unsaturated double bonds of omethoate and produce phosphate ion, eventually leading to omethoate destruction. It is concluded that appropriate dosage of LTP can effectively degrade omethoate residue in fruits and vegetables without affecting their quality.

关键词： DBCD plasma omethoate residue quality of fruits and vegetables reactive oxygen and nitrogen species