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Suppression Effect of Superoxide Dismutase (SOD)-Like Activity Protein Partially Purified from raphnus sativus Leaves against Liver Metastasis in Mice Intraperitoneally Infected with Ehrlich Ascites Carcinoma Cell

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Natural Science 2016年第7期8卷 321-332页

作者： El-Shahat A. Toson Fahed M. Almutairi Amira Ali Elfalal Salem A. Habib Rasha F. Zahran Mohamed Elbakry Division of Biochemistry Department of Chemistry Faculty of Science Damietta University Damietta Egypt Department of Biochemistry Faculty of Science University of Tabuk Tabuk Kingdom of Saudi Arabia Department of Botany Faculty of Science Damietta University Damietta Egypt Division of Biochemistry Department of Chemistry Faculty of Science Tanta University Tanta Egypt

Liver metastasis is a normal result in Ehrlich Ascites Carcinoma Cell (EAC) infected mice. A partially purified protein with Superoxide Dismutase (SOD)-like activity extracted from leaves of raphnus sativus was tested for its ability to down regulate liver metastasis of Ehrlich Ascites Carcinoma Cell (EAC) intraperitoneally implanted in albino mice. Sixty albino mice were divided equally into 4 groups. Group I mice (G1 control) were treated with physiologic saline solution for 7 days. Group 2 mice (G2) were injected with the partially purified protein. Group 3 mice (G3) were intraperitoneally inoculated with EAC cells and treated with the partially purified protein. Group 4 mice (G4) were inoculated EAC cells and treated with physiologic saline solution. The results showed a disturbance in liver functions. This disturbance was observed as a reduction in the values of serum albumin, hemoglobin, total counts of erythrocytes and platelets, total lipids in liver tissues, erythrocytes SOD activity, serum glucose, reduced glutathione (GSH) and the trace elements (Fe, Mn, Zn, and Cu) contents in liver and spleen tissues as well as the elevation of serum transaminases activities, the levels of malondialdehyde in blood, DNA and RNA of liver tissues in the infected mice (G4). On the other hand, in G3, after treatment with the partial purified protein all these parameters restored their normal values and became near from the normal group (GI). Moreover, the protein showed no toxicity towards the mice as shown in G2. It could be concluded that a partially purified protein with Superoxide Dismutase (SOD)-like activity extracted from leaves of raphnus sativus as a nature source has a promised future in controlling liver metastasis.

关键词： Apoptosis Transformed Cells raphnus sativus SOD-Like Activity EAC Cells Liver Metastasis

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