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Rhythmical massage improves autonomic nervous system function:a single-blind randomised controlled trial

Journal of Integrative Medicine 2018年第3期16卷 172-177页

作者： Georg Seifert Jenny-Lena Kanitz Carolina Rihs Ingrid Krause Katharina Witt Andreas Voss Department of Pediatric Oncology and Hematology Charité-Universit?tsmedizin Berlin Institute of Innovative Health Technologies Ernst-Abbe-Hochschule University of Applied Sciences

Background： Rhythmical massage therapy（RMT） is a massage technique used in anthroposophic ***： The authors aimed to investigate the physiological action of RMT on the cardiovascular system by analysing heart rate variability（HRV）.Design, setting, participants and intervention： This study was a randomised, controlled and single-blinded trial, involving 44 healthy women（mean age：（26.20 ± 4.71） years）. The subjects were randomised to one of three arms： RMT with aromatic oil（RA）, RMT without aromatic oil（RM） or standardised sham massage（SM）. In the study the subjects were exposed to a standardised stress situation followed by one of the study techniques and Holter electrocardiograms（ECGs） were recorded for 24 *** outcome measures： HRV parameters were calculated from linear（time and frequency domain） and nonlinear dynamics（symbolic dynamics, Poincare plot analysis） of the 24-h Holter ECG ***： Short-and long-term effects of massage on autonomic regulation differed significantly among the three groups. Immediately after an RMT session, stimulation of HRV was found in the groups RA and RM. The use of an aromatic oil produced greater short-term measurable changes in HRV compared with rhythmic massage alone, but after 24 h the effect was no longer distinguishable from the RM *** lowest stimulation of HRV parameters was measured in the SM ***： RMT causes specific and marked stimulation of the autonomic nervous system. Use of a medicinal aromatic oil had only a temporary effect on HRV, indicating that the RM causes the most relevant long-term effect. The effect is relatively specific, as the physiological effects seen in the group of subjects who received only SM were considerably less pronounced.

关键词： Sham massage Well-being Mood Alertness Relaxation Stress Heart rate variability randomised controlled trial

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Effects of moderate-intensity aerobic exercise combined with acupuncture on attention function of mentally-retarded adolescents:a randomised controlled trial

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Journal of Traditional Chinese Medicine 2023年第1期43卷 154-159页

作者： LI Shuoqi GUO Rong LIU Chunjing ZHAI Jiali LI Keke LI Shiming YU Wenbing School of Health Science Universiti Sains MalaysiaKota Bharu 15100Malaysia School of Foreign Languages Ludong UniversityYantai 264025China Department of Physical Education Qingdao Technical CollegeQingdao 266400China School of Rehabilitation Medicine Binzhou Medical UniversityYantai 264003China Laboratory of Sports and Human Sciences Ocean University of ChinaQingdao 266100China

OBJECTIVE:To detect the impact of moderate-intensity aerobic exercise combined with acupuncture on the attention function of mentally-retarded adolescents from the three dimensions of attention concentration,attention transfer and attention ***:A total of 48 adolescents with mild to moderate mental disabilities were *** participants were randomly divided into four groups:control group(C),Traditional Chinese Medicine acupuncture group(M),moderate-intensity aerobic exercise group(E)and exercise and acupuncture combined intervention group(J).Before and after the experimental intervention,the participant’s height,weight and attention ability were ***:The improved range of attention total duration of the J group after the intervention was significantly higher than that of the E and M groups(P0.05),whereas the E,M and J groups increased significantly(P<0.05)after intervention than the C ***:Moderate-intensity aerobic exercise combined with acupuncture can more effectively improve the attention concentration and attention span of mentally-retarded adolescents than aerobic exercise or acupuncture alone.

关键词： acupuncture exercise intellectual disability adolescent attention function randomised controlled trial

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Biodegradable stent or balloon dilatation for benign oesophageal stricture: Pilot randomised controlled trial

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World Journal of Gastroenterology 2014年第48期20卷 18199-18206页

作者： Anjan Dhar Helen Close Yirupaiahgari K Viswanath Colin J Rees Helen C Hancock A Deepak Dwarakanath Rebecca H Maier Douglas Wilson James M Mason Department of Gastroenterology County Durhamand Darlington NHS Foundation Trust Co. Durham DL14 6ADUnited Kingdom Durham Clinical trials Unit School of Medicine Pharmacy and Health Durham University Queen’s Campus Wolfson Research Institute University Boulevard Stockton-on-Tees TS17 6BH United Kingdom Department of Surgery James Cook University Hospital Marton Road Middlesbrough TS4 3BW United Kingdom Department of Gastroenterology South Tyneside Hospitals NHS Foundation Trust Harton Lane South Shields NE34 0PL United Kingdom Department of Gastroenterology University Hospitals of North Tees Hardwick Stockton on Tees TS19 8PE United Kingdom

AIM: To undertake a randomised pilot study comparing biodegradable stents and endoscopic dilatation in patients with strictures.

关键词： Benign oesophageal stricture Biodegradable stent Endoscopic balloon dilatation Pilot study randomised controlled trial Dysphagia

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Multicenter randomised controlled trial comparing the high definition white light endoscopy and the bright narrow band imaging for colon polyps

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World Journal of Gastrointestinal Endoscopy 2017年第6期9卷 273-281页

作者： Rajvinder Singh Kuan Loong Cheong Leonardo Zorron Cheng Tao Pu Dileep Mangira Doreen Siew Ching Koay Carmen Kee Siew Chien Ng Rungsun Rerknimitr Satimai Aniwan Tiing-Leong Ang Khean-Lee Goh Shiaw Hooi Ho James Yun-Wong Lau Gastroenterology Department Lyell McEwin Hospital(NALHN School of Medicine the University of Adelaide Flinders Medical Centre South AustraliaAustralia Prince of Wales Hospital Chulalongkorn University Changi General Hospital University of Malaya Medical Centre

AIM To compare high definition white light endoscopy and bright narrow band imaging for colon polyps' detection rates. METHODS Patients were randomised to high definition white light endoscopy(HD-WLE) or the bright narrow band imaging(b NBI) during withdrawal of the colonoscope. Polyps identified in either mode were characterised using b NBI with dual focus(b NBI-DF) according to the Sano's classification. The primary outcome was to compare adenoma detection rates(ADRs) between the two arms. The secondary outcome was to assess the negative predictive value(NPV) in differentiating adenomas from hyperplastic polyps for diminutive rectosigmoid *** A total of 1006 patients were randomised to HD-WLE(n = 511) or b NBI(n = 495). The mean of adenoma per patient was 1.62 and 1.84, respectively. The ADRs in b NBI and HD-WLE group were 37.4% and 39.3%, respectively. When adjusted for withdrawal time(OR = 1.19, 95%CI: 1.15-1.24, P < 0.001), the use of b NBI was associated with a reduced ADR(OR = 0.69, 95%CI: 0.52-0.92). Nine hundred and thirty three polyps(86%) in both arms were predicted with high confidence. The sensitivity(Sn), specificity(Sp), positive predictive value and NPV in differentiating adenomatous from non-adenomatous polyps of all sizes were 95.9%, 87.2%, 94.0% and 91.1% respectively. The NPV in differentiating an adenoma from hyperplastic polyp using b NBI-DF for diminutive rectal polyps was 91.0%.CONCLUSION ADRs did not differ between b NBI and HD-WLE, however HD-WLE had higher ADR after adjustment of withdrawal time. b NBI surpassed the PIVI threshold for diminutive polyps.

关键词： Narrow band imaging Dual focus High definition White light endoscopy Colon Polyps randomised controlled trial

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An intensive and personalised care planning programme improves clinical outcomes in patients with diabetic retinopathy:a pilot randomised controlled trial

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Annals of Eye Science 2020年第1期5卷 9-14页

作者： Amudha Aravindhan Eva K.Fenwick Ryan Eyn Kidd Man Aw Ai Tee Ecosse L.Lamoureux Singapore Eye Research Institute Singapore Duke-NUS Medical School Singapore Singapore National Eye Centre Singapore National University of Singapore Singapore

Background:Using a pilot randomised controlled trial(RCT),to assess the short-term effectiveness of a structured diabetic retinopathy(DR)-specific,intensive,and personalised care planning(DR-IPCP)intervention on diabetes control outcomes in Singaporeans with poorly controlled type 2 ***:Eighteen individuals with mild-moderate DR and poor glycemic control[HbA1c≥64 mmol/mol(≥8.0%)over two consecutive 6-month readings]were randomized to DR-IPCP(n=9)or usual care(UC,n=9).The intervention included a physician consultation,an initial personalised eye consultation with a experienced diabetes nurse educator,and three behaviour change follow-up ***1c(primary outcome),lipids and blood pressure were assessed at baseline and three months *** feedback regarding the DR-IPCP program was collected at three months via a semi-structured telephone ***:While no significant between-group differences were observed,DR-IPCP participants experienced significant within-group reductions in HbA1c,total cholesterol,and low density lipoprotein at follow-up compared to baseline[7 mmol/mol(−0.8%),−0.64 mmol/L,and−0.66 mmol/L,respectively].No significant within-group changes in these parameters were observed in the UC *** the DR-IPCP intervention,participants reported a clearer understanding of the link between diabetes management;the development and progression of ***:DR-IPCP provides an effective short-term improvement in diabetes control parameters in DR patients with poor diabetes *** adequately powered and longitudinal RCT is warranted to assess the clinical,patient-centred and economic potential of this programme in this population.

关键词： Diabetic retinopathy randomised controlled trial diabetes control personalised care planning intervention behaviour

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Acupuncture of different stimulation for the treatment of neck type cervical spondylosis:a randomised controlled trial

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TMR Non-Drug Therapy 2021年第3期4卷 34-39页

作者： Da Li Chun-Yan Chen Wei Zhang Jia-Yu Huang Ren-Hong Wan Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China Tianjin University of Traditional Chinese Medicine Tianjin 301617China

Objective:To observe the difference in clinical efficacy of acupuncture with strong and weak stimulation in treating neck type cervical ***:64 patients with neck type cervical spondylosis were randomly divided into strong stimulation group and weak stimulation group,with 32 cases in each *** acupoints selected are Jingjiaji 5-7(cervical acupoints EX-B2 C5-C7),Tianzhu(BL10)on both sides,Houxi(SI3)on both sides,Hegu(LI4)on both sides,Geshu(BL17)on both sides,and *** the strong stimulation group,deep needling with 0.25 mm×40 mm milli-needle was performed,with a mild reinforcing-reducing *** twisting angle was 90°-180°,the frequency was 60-90 times/min,and the needles were applied for 1 min at each *** the needle for 30 minutes,twisting was performed every 10 min during the retention *** hands *** the weak stimulation group,shallow acupuncture with a 0.18 mm×40 mm milli-needle was performed,with a mild reinforcing-reducing method,with a twisting angle of 60°-90°,a frequency of 30-60 times/min,and acupuncture for 10 seconds at each *** the needle for 30 minutes,and no needle during the retention *** in both groups were treated once every 1 to 2 days,3 times a week for 2 weeks,and followed up for 1 month after all *** two groups of patients were compared before and after treatment and during *** McGill pain questionnaire score and the cervical spine dysfunction index score were compared to determine the clinical *** analysis was performed using SPSS 22.0 statistical ***:1 case drop-out in the strong stimulation group and 1 case in the weak stimulation *** total effective rate of the strong stimulation group was 90.32%,the total effective rate of the weak stimulation group was 83.87%,and the total effective rate of the strong stimulation group was higher than that of the weak stimulation group(P<0.05).The total scores of the short-form McGill

关键词： Acupuncture Irritation Neck type cervical spondylosis randomised controlled trial

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Educational Video Increases Maternal Self-Efficacy for Prevention of Diarrhoea in Young Children:A randomised Clinical trial

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Health 2014年第21期6卷 2867-2874页

作者： Emanuella Silva Joventino Adria Marcela Vieira Ferreira Maria de Fátima Pereira de Sousa Jardeliny Correa da Penha Monica Oliveira Batista Oria Paulo Cesar de Almeida Lorena Barbosa Ximenes Department of Nursing Federal University of CearáFortalezaBrazil University of the State of Ceará FortalezaBrazil

The aim of this study was to compare the scores of maternal self-efficacy for child diarrhoea prevention, between intervention and control groups, according to sanitary, social and demographic characteristics. A randomised clinical trial was carried out on 163 mothers of children under 5 years old. Data collection was conducted during two months, at two different moments (M0 and M1);at the moment M0 only the intervention group watched the educational video to promote self-efficacy for child diarrhoea prevention;at M1 (two months later) the scale was applied to both groups. In the intervention group, greater mean self-efficacy scores were obtained compared with the control group. The following variables showed statistically significant associations (p < 0.05) with maternal self-efficacy: age 35 or over;high school education;working outside the home;residence with 4 to 5 people;house not of brick or mortar;public refuse collection;piped water supply;consumption of mineral water;and public sewerage network. After use of the video “Diarrhoea: you can prevent it”, the maternal self-efficacy increased, proving that this strategy is able to assist the nursing staff in educational practices.

关键词： Health Education Diarrhoea Infantile Maternal Behaviour randomised controlled trial

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Effects of perioperative rosuvastatin on postoperative delirium in elderly patients:A randomized,double-blind,and placebo-controlled trial

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World Journal of Clinical Cases 2021年第21期9卷 5909-5920页

作者： Xiao-Qin Xu Jing-Zhi Luo Xiao-Yu Li Hai-Qin Tang Wei-Hong Lu Department of Anesthesiology Wuxi Clinical College of Anhui Medical University904th Hospital of Joint Logistic Support Force of PLAWuxi Clinical College of Anhui Medical UniversityWuxi 214044Jiangsu ProvinceChina

BACKGROUND Experimental evidence has indicated the benefits of statins for the treatment of postoperative ***,clinical trials did not reach definite conclusions on the effects of statins on *** clinical trials have indicated that statins reduce postoperative delirium and improve outcomes,while some studies have reported negative *** To evaluate whether perioperative rosuvastatin treatment reduces the incidence of delirium and improves clinical *** This randomized,double-blind,and placebo-controlled trial was conducted in a single center in Jiangsu,*** study enrolled patients aged greater than 60 years who received general anesthesia during elective operations and provided informed consent.A computer-generated randomization sequence(in a 1:1 ratio)was used to randomly assign patients to receive either rosuvastatin(40 mg/d)or ***,care providers,and investigators were all masked to group *** primary endpoint was the incidence of delirium,which was assessed twice daily with the Confusion Assessment Method during the first 7 postoperative *** were performed on intention-to-treat and safety *** Between January 1,2017 and January 1,2020,3512 patients were assessed.A total of 821 patients were randomly assigned to receive either placebo(n=411)or rosuvastatin(n=410).The incidence of postoperative delirium was significantly lower in the rosuvastatin group[23(5.6%)of 410 patients]than in the placebo group{42(13.5%)of 411 patients[odds ratios(OR)=0.522,95%confidence interval(CI):0.308-0.885;P<0.05]}.No significant difference in 30-d all-cause mortality(6.1%vs 8.7%,OR=0.67,95%CI:0.39-1.2,P=0.147)was observed between the two *** decreased the hospitalization time(13.8±2.5 vs 14.2±2.8,P=0.03)and hospitalization expenses(9.3±2.5 vs 9.8±2.9,P=0.007).No significant differences in abnormal liver enzymes(9.0%vs 7.1%,OR=1.307,95%CI:0.787-2.169,P=0.30)or rhabdomyol

关键词： Perioperative rosuvastatin Postoperative delirium Elderly General anesthesia randomised controlled trial

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Effects of Ginkgo Biloba Special Extract EGb 761^(█) in Very Mild Cognitive Impairment(vMCI)

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Neuroscience & Medicine 2011年第1期2卷 48-56页

作者： Brigitte Grass-Kapanke Arija Busmane Andris Lasmanis Robert Hoerr Reiner Kaschel Alexian Hospital Krefeld KrefeldGermany Adoria Clinic RigaLatvia Alma Clinic RigaLatvia Dr.Willmar Schwabe GmbH&Co.KG Pharmaceuticals KarlsruheGermany University of Osnabrueck OsnabrueckGermany

Objective: To assess effects of EGb 761? on cognition and quality of life in subjects with very mild cognitive impair-ment. Methods: We randomized 300 subjects aged 45 to 65 with cognitive complaints and low functioning (more than one standard deviation below appropriate norm) in at least one cognitive test to double-blind treatment with once daily 240 mg EGb 761? or placebo for 12 weeks. Results: The exploratory intention-to-treat analysis showed significant im-provement (p < 0.025, one-sided) beyond practice effects for EGb 761? in a measure of attention (Vienna Test System - Work Performance Series) and trends in favour of EGb 761? in measures of memory (Wechsler Memory Scale III - Faces I, Appointments Test – delayed recall), and perceived physical health (SF36 - factor score Physical Health). Cognitive effects were more pronounced and more consistent (p < 0.025 in 4 of 5 tests) in subjects with lower memory function at baseline. Specifically, practice effects in the more demanding tests were attenuated or absent in these sub-jects. Conclusion: Ginkgo biloba extract EGb 761? improved cognitive functioning and aspects of quality of life in sub-jects with very mild cognitive impairment.

关键词： Ginkgo Biloba EGb 761^(█) Mild Cognitive Impairment Memory Concentration randomised controlled trial

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