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Design of SERS nanoprobes for raman imaging:materials, critical factors and architectures

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Acta Pharmaceutica Sinica B 2018年第3期8卷 381-389页

作者： Mingwang Li Yuanyuan Qiu Chenchen Fan Kai Cui Yongming Zhang Zeyu Xiao Department of Pharmacology and Chemical Biology Institute of Medical Sciences Shanghai Jiao Tong University School of Medicine Translational Medicine Collaborative Innovation Center Shanghai Jiao Tong University School of Medicine Collaborative Innovation Center of Systems Biomedicine Shanghai Jiao Tong University School of Medicine

raman imaging yields high specificity and sensitivity when compared to other imaging modalities, mainly due to its fingerprint signature. However, intrinsic raman signals are weak, thus limiting medical applications of raman imaging. By adsorbing raman molecules onto specific nanostructures such as noble metals, raman signals can be significantly enhanced, termed surfaceenhanced raman scattering(SERS). Recent years have witnessed great interest in the development of SERS nanoprobes for raman imaging. Rationally designed SERS nanoprobes have greatly enhanced raman signals by several orders of magnitude, thus showing great potential for biomedical *** this review we elaborate on recent progress in design strategies with emphasis on material properties,modifying factors, and structural parameters.

关键词： raman imaging Surface-enhanced raman scattering Nanoprobes Architecture Biomedical application Enhancement factors Nanoparticles

Investigating Microplastics and Nanoplastics Released from a Rubber Band Used for Orthodontic Treatment with Improved raman imaging Algorithms

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Environment & Health 2023年第1期1卷 63-71页

作者： Cheng Fang Olalekan Simon Awoyemi Yunlong Luo Ravi Naidu Global Centre for Environmental Remediation(GCER)and Cooperative Research Centre for Contamination Assessment and Remediation of the Environment(CRC CARE) University of NewcastleCallaghanNSW 2308Australia Global Centre for Environmental Remediation(GCER) University of NewcastleCallaghanNSW 2308Australia

Most teenagers experience orthodontic treatment,but we do not know the possible adverse effect of the released microplastics and nanoplastics that are recently categorized as emerging ***,we test the rubber band that has been employed to improve the biting of teeth during the orthodontic process to confirm the release of microplastics and *** improve the characterization of microplastics and nanoplastics by(i)raman imaging,to extract and map the signal from the scanning spectrum matrix or the hyperspectral matrix and to enhance the signal-to-noise ratio *** effectively extract the signal,(ii)chemometrics such as principal component analysis(PCA)are explored to convert the hyperspectral matrix to an image with an increased *** nonsupervised PCA is intentionally corrected,via(iii)the algebra-based algorithm,to further increase the certainty to image the microplastics and *** the signal is weak,(iv)an additional algorithm of image reconstruction via deconvolution is developed to average the background noise and smooth the *** doing so,we estimate that millions of microplastics and nanoplastics are released daily in potential from a rubber band applied in a teenager's mouth,which might be a big ***,our approach provides a suitable option to characterize the microplastics and nanoplastics from a complex background.

关键词： orthodontics rubber band microplastics nanoplastics raman imaging algorithm deconvolution

raman Micro-imaging of the Coexistence of sⅠ and sⅡ Hydrates Formed from a Mixed Methane-Propane Gas in a Confined Space

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Acta Geologica Sinica(English Edition) 2022年第2期96卷 674-679页

作者： CAI Wenjiu ZHAN Linsen HUANG Xin LU Hailong College of Engineering Peking UniversityBeijing 100871China Beijing International Center for Gas Hydrate School of Earth and Space SciencesPeking UniversityBeijing 100871China SINOPEC Petroleum Exploration and Production Research Institute Beijing 100083China

Natural gas hydrate contains a specific amount of heavy hydrocarbons, such as ethane, propane, etc., aside from the primary guest gas of methane. Although the coexistence of two or even three hydrate structures has been discovered at several hydrate sites, the requisite formation mechanism is still not well understood. In-situ observation of the formation process of mixed methane-propane hydrate in a confined space was conducted using confocal raman imaging microscopy. The raman imaging results reveal that sI methane hydrate and sII mixed methane-propane hydrate are formed and coexist in the reaction system. In the confined space, the sI hydrate originates from the dissolved gas in water, while the sII hydrate is formed from free gas. The results obtained can help explain the coexistence of sI and sII hydrates found in natural hydrate samples, as well as providing insights into a possible dynamic scenario of hydrate reservoirs in geological history.

关键词： raman imaging mixed hydrate coexistence sⅠhydrate sⅡhydrate

Silicone matrices for controlled dexamethasone release:toward a better understanding of the underlying mass transport mechanisms

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Regenerative Biomaterials 2023年第1期10卷 498-509页

作者： Thitiphorn Rongthong Adam Qnouch Maria Maue Gehrke Laurent Paccou Paulo Oliveira Florence Danede Jeremy Verin Christophe Vincent Jean-Francois Willart Florence Siepmann Juergen Siepmann Univ.Lille INSERMCHU LilleU1008F-59000 LilleFrance Univ.Lille UMR CNRS 8207UMETF-59655 Villeneuve d’AscqFrance

Dexamethasone-loaded silicone matrices offer an interesting potential as innovative drug delivery systems,*** the treatment of inner ear diseases or for ***,very long drug release periods are targeted:several years/*** renders the development and optimization of novel drug products cumbersome:experimental feedback on the impact of the device design is obtained very slowly.A better understanding of the underlying mass transport mechanisms can help facilitating research in this field.A variety of silicone films were prepared in this study,loaded with amorphous or crystalline *** polymorphic drug forms were investigated,the film thickness was altered and the drug optionally partially/completely exchanged by much more water-soluble dexamethasone‘phosphate’.Drug release studies in artificial perilymph,scanning electron microscopy,optical microscopy,differential scanning calorimetry,X-ray diffraction and raman imaging were used to elucidate the physical states of the drugs and polymer,and of the systems’structure as well as dynamic changes thereof upon exposure to the release *** particles were initially homogeneously distributed throughout the *** hydrophobicity of the matrix former very much limits the amounts of water penetrating into the system,resulting in only partial drug *** mobile drug molecules diffuse out into the surrounding environment,due to concentration ***,raman imaging revealed that even very thin silicone layers(<20µm)can effectively trap the drug for prolonged periods of *** physical state of the drug(amorphous,crystalline)did not affect the resulting drug release kinetics to a noteworthy extent.

关键词： silicone matrix drug release mechanism dexamethasone dexamethasone phosphate raman imaging

Visualization of Ferroelectric Domains in Thin Films of Molecular Materials Using Confocal Micro-raman Spectroscopy

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Chemical Research in Chinese Universities 2022年第6期38卷 1394-1399页

作者： ZHOU Wenqin FENG Zijie XIONG Yuan DU Guowei LIN Xiumei SU Qidong LOU Yuheng AN Shili YOU Yumeng Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics Southeast UniversityNanjing211189P.R.China School of Chemistry and Chemical Engineering Southeast UniversityNanjing211189P.R.China

Ferroelectrics are an important class of functional *** all their unique properties,the study of their ferroelectric domains and domain walls is of great interest due to their importance in ferroelectric *** are many methods to characterize ferroelectric domains,namely,scanning probe microscopy,optical microscopy,electron microscopy,***,newly emerged molecular ferroelectrics are attracting much attention from chemists,physicists and researchers in material sciences due to their structural flexibility,light mass,simple fabrication,***,for the characterization of molecular ferroelectric domains,most conventional methods require either a complicated preparation process or direct contact between physical probes and material surfaces,limiting the development of molecular ferroelectric *** this report,we have demonstrated that confocal micro-raman spectroscopy,as a nondestructive and noncontact in-situ method,is very suitable for studying the ferroelectric polarization and structures of domains in molecular *** recently reported molecular ferroelectric trimethylchloromethyl ammonium trichlorocadmium(II)(TMCM-CdCl_(3))as an example,the non-180°domains have been characterized and visualized at different *** a simple and extendable method requires minimum sample preparation,which would further benefit the research of molecular ferroelectric domain engineering and promote the miniaturization and integration of molecular ferroelectric films.

关键词： Molecular ferroelectric Ferroelectric film Domain Polarized raman spectroscopy raman imaging

Tracking the Ti^(4+)substitution in phlogopite by spectroscopic imaging:A tool for unravelling the growth of micas at HP-HT conditions

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Geoscience Frontiers 2024年第3期15卷 1-13页

作者： G.Della Ventura N.El Moutaouakkil B.Boukili S.Bernardini A.Sodo L.Pronti M.Cestelli-Guidi F.Holtz F.Lucci Dipartimento di Scienze UniversitàRoma TreRomaItaly INFN-LNF via Fermi 200040 FrascatiRomaItaly INGV Via di Vigna Murata 60500143 RomaItaly Laboratory of Géosciences Water and Environment.Department of Earth Sciences.Faculty of SciencesUniversity Mohammed VRabatMorocco Leibnitz Universität Hannover Institute of MineralogyCallinstr 330167 HannoverGermany Dipartimento di Scienze della Terra e Geoambientali Universitàdi Bari“Aldo Moro”BariItaly

Phlogopite solid-solutions have a wide pressure-temperature(P-T)stability field and are ubiquitous in a wide variety of geological settings,from deep lithosphere magmatic environments to upper crust metamorphic *** composition represents therefore a valuable physical-chemical archive and may provide important information regarding its crystallization and the petrogenesis of the *** this paper we examine the phlogopite phenocrysts from the well-known Fort Regent mica-bearing lamprophyre minette from ***(Island of Jersey,UK).Phlogopite phenocrystals from lamprophyres generally show normal-step and continuous compositional zoning,however those from the Fort Regent minette show a peculiar texture characterized by dark brown high-Ti(average TiO_(2)≈8.5 wt.%)cores enveloped by euhedral low-to mid-amplitude zonation due to oscillatory contents in Ti,Fe and ***-barometry modelling based on biotite-only composition yields relatively high P-T estimates(T≈970±54℃at P≈0.73±0.13 GPa)for cores whereas lower values(T≈790±54℃at P≈0.29±0.13 GPa)are obtained for the outer *** temperatures(T≈1075±54℃)but extremely high and anomalous pressure values(P≈1.82±0.13 GPa)are obtained for the yellowish inner *** combination of electron micro probe(EMP)analysis and single-crystal infra-red(FTIR)imaging in the OH-stretching region shows that the exceptional and oscillatory Ti contents are due to the Ti-vacancy substitution,typical of crystallization and growth processes of HP/HT *** imaging provides additional insight for this process,confirming the dominant dioctahedral nature for the Ti-Fe-rich cores and outer *** of thermobaric estimates obtained from the phlogopite compositiononly model,based on the fine-scale compositional evolution,shows that pressure-temperature values from low-Ti high-Mg domains should be carefully evaluated because the substitution mechanisms during the dark mica growth are not univocal

关键词： Ti-phlogopite Jersey minette(UK) Ti-substitution FTIR imaging raman imaging Thermobarometric modelling

Recent advances in raman spectroscopy for skin diagnosis

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Journal of Innovative Optical Health Sciences 2023年第3期16卷 13-31页

作者： Min Wu Beibei Gao Xunbin Wei Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong UniversitySchool of Medicine Shanghai 200011P.R.China School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200240P.R.China Institute of Medical Technology Peking University Beijing 100181P.R.China Biomedical Engineering Department Peking University Beijing 100081P.R.China International Cancer Institute Peking University Beijing 100191P.R.China

The skin is the largest organ in *** comprises about 16%of our *** diseases originate from the skin,including acne vulgaris,skin cancer,fungal skin disease,*** a common skin cancer in China,melanoma alone grows at year rate of nearly 4%.Therefore,it is crucial to develop an objective,reliable,accurate,non-invasive,and easy-to-use diagnostic method for skin diseases to support clinical *** spectroscopy is a highly specic imaging technique,which is sensitive,even to the single-cell level in skin *** spectroscopy provides a pattern of signals with narrow bandwidths,making it a common and essential tool for researching individual characteristics of skin *** spectroscopy already has a number of clinical applications,including in thyroid,cervical and colorectal *** review will introduce the advantages and recent developments in raman spectroscopy,before focusing on the advances in skin diagnosis,including the advantages,methods,results,analysis,and ***,we discuss the current limitations and future progress of raman spectroscopy in the context of skin diagnosis.

关键词： raman spectroscopy skin diagnosis raman imaging melanoma

Recent application of raman spectroscopy in tumor diagnosis:from conventional methods to artificial intelligence fusion

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PhotoniX 2023年第1期4卷 293-334页

作者： Yafeng Qi Yuhong Liu Jianbin Luo State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

raman spectroscopy,as a label-free optical technology,has widely applied in tumor *** on the different raman technologies,conventional diagnostic methods can be used for the diagnosis of benign,malignant and subtypes of *** the past 3 years,in addition to traditional diagnostic methods,the application of artificial intelligence(AI)in various technologies based on raman technologies has been developing at an incredible *** on this,three technical methods from single spot acquisition(conventional raman spectroscopy,surface-enhanced raman spectroscopy)to raman imaging are respectively introduced and analyzed the diagnosis process of these technical ***,the emerging AI applications of tumor diagnosis within these methods are highlighted and ***,the challenges and limitations of existing diagnostic methods,and the prospects of AI-enabled diagnostic methods are presented.

关键词： raman spectroscopy raman imaging SERS Artificial intelligence Tumor diagnosis

Labeling and Visualizing Glycans with Specificity and Versatility

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Labeling and Visualizing Glycans with Specificity and Versat...