检索结果-南通市图书馆

Variations in the Composition of Fructus Evodiae after Processing with radix glycyrrhizae Extract

Chinese Journal of Integrative Medicine 2012年第10期18卷 782-787页

作者：肖碧英毛淑杰李先端 Jiangxi University of Traditional Chinese Medicine Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences

Objective： To evaluate the changes in the concentrations of five components in Fructus Evodiae used in Chinese medicine, including evodiamine and glycyrrhizic acid, during processing of Fructus Evodiae with radix glycyrrhizae extract by using high performance liquid chromatography （HPLC） and to provide a scientific basis for different clinical uses of processed and unprocessed Fructus Evodiae. Methods： The concentrations of the Fructus Evodiae components in processed or unprocessed Fructus Evodiae were evaluated by HPLC using a YMC J＇sphere ODS-H80 column （4.6 mm × 250 ram, 5 μm） with acetonitrile-water-tetrehydrofuran-acetic acid （41：59：1：0.2, v/v/v/v） as the mobile phase. The detection wavelength was 225 nm, the column temperature was 35 %, the flow rate was 1.0 mL/min, and the injection volume was 10 μL. The concentrations of the radix glycyrrhizae components were determined by HPLC with a KromasiI-C18 column （4.6 mm × 250 mm, 4 μm） and a gradient elution of acetonitrile （A） and 0.05% aqueous phosphoric acid （B） as the mobile phase. The detection wavelength was 237 nm, the column temperature was 35 ℃, the flow rate was 1.0 mlEmin, and the injection volume was 10μL. Results： The calibration curves of evodia lactone, evodiamine, rutaecarpine, liquiritin, and glycyrrhizin showed good linear relationships （r〉0.99）. The recoveries of evodia lactone, evodiamine, rutaecarpine, liquiritin, and glycyrrhizin were 96.59%, 104.18%, 101.91%, 97.75%, and 97.95%, respectively. The concentrations of the components in processed Fructus Evodiae were obviously different to those in unprocessed Fructus Evodiae. Conclusions： The developed method is rapid and accurate. The results provide a reference for processed Fructus Evodiae and the changes that could be expected in its effects compared to unprocessed Fructus Evodiae.

关键词： radix glycyrrhizae Fructus Evodiae high performance liquid chromatography

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Screening for cyclooxygenase 2 inhibitors from natural compounds of radix glycyrrhizae using computer simulation

引用

Traditional Medicine Research 2018年第3期3卷 115-130页

作者： Ming Yang Yi Jin Li-Ping Yang Department of Pharmacy of Beijing Hospital National Center of Gerontology Assessment of Clinical Drugs Risk and Individual Application Key Laboratory National Clinical Research Center of Respiratory Diseases Beijing China School of Life Sciences and Biopharmaceuticals Shenyang Pharmaceutical University Shenyang China

Objective： To explore the molecular basis of the effects of Gancao （radix glycyrrhizae, GC） on inflammation throughthe inhibition of cyclooxygenase 2 （COX-2）. Methods： The Discovery Studio 4.5 System was used to predict thephysicochemical properties of GC molecular compounds. The Ligand Profiler was used to screen for natural GCcomponents that could combine with the COX-2 pharmacophores. The AutoDock Vina 1.1.2 software was used for themolecular docking of the natural GC components with the COX-2 protein. Results： The aromatics were the closest to thenon-steroidal anti-inflammatory drugs in terms of the three properties, namely molecular weight, molecular surface area,and molecular solubility, followed by the flavonoids; whereas the terpenoids/saponins differed most from thenon-steroidal anti-inflammatory drugs in terms of the three properties; and the aliphatics were inconsistent. One hundredand eighteen small molecules were obtained through the pharmacophore screening using GC. The molecular bindingenergy （MBE） results demonstrated that the MBE value of the flavonoids/aromatics, obtained from their binding with theCOX-2 protein, was lower than that obtained from their binding with the substrate, metabolism of arachidonic acid,whereas the MBE value of the aliphatics/terpenoids, obtained from their binding with the COX-2 protein, was higherthan that obtained from their binding with the substrate, arachidonic acid. Finally, further filtration, based on thephysicochemical properties and the molecular binding energies of the small molecules, was carried out. Forty-twonatural GC components, including 35 flavonoid and 7 aromatic constituents, with low binding energies and potentialinhibitory effects on COX-2, were screened. Conclusion： Using the three-step program, pharmacophore screening,molecular docking, and physicochemical properties analysis, we screened out 35 flavonoid molecules and 7 aromaticmolecules, which may be potential COX-2 inhibitors, from GC. Two of the

关键词： radix glycyrrhizae COX-2 Pharmacophores Molecular docking Physicochemical properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A systematic summary of natural compounds in radix glycyrrhizae

引用

Traditional Medicine Research 2018年第2期3卷 1-13页

Objective： To accumulate data from studies on the compounds identified from Gancao （radix glycyrrhizae, GC）, andthen systematically summarize and classify these compounds according to their structural characteristics. Methods： Fivedatabases （CNKI, VIP, Wanfang data, CBM, and Pubmed） were used to search for studies on the chemical structure ofcompounds from GC. The retrieval time of the respective databases was from their inception to March 2016. Accordingto the inclusion and exclusion criteria, the papers were carefully screened, and the data were extracted. Results： A totalof 653 compounds from GC were collated from 252 articles, including flavonols （n = 201） belonging to 10 subgroups,terpenes and saponins （n = 167）, coumarins （n = 30） belonging to 3 subgroups, aliphatics （n = 206）, aromatics （n = 35）,and others （n = 14）. The flavones, represented by liquiritin and liquiritigenin, were the most reported compounds isolatedfrom GC, followed by terpenes and saponins such as glycyrrhizic acid and glycyrrhetinic acid. Conclusion： The morethan 600 natural compounds in GC may be responsible for GC’s anti-inflammatory, phlegm-expelling, cough- andpain-relieving activities.

关键词： radix glycyrrhizae Flavonol Terpene Saponin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intellectual Property Protection and High Quality Development of radix glycyrrhizae for Treatment of COVID-19

引用

Asian Agricultural Research 2020年第5期12卷 1-6页

作者： Yuanpeng SUN Yanling SUN Zheng CHENG Yusi LIU Zhe WU College of Basic Medicine Hubei University of Science and Technology Xianning 437100 China

radix glycyrrhizae is the dominant native medicinal material variety in the north and northwestern medicinal materials producing *** is a main Chinese medicine of effective TCM drugs and formulas for the treatment of new coronavirus disease(COVID-19).This paper introduces the medicinal value of radix glycyrrhizae,involving the labeling,cultural heritage,and creative intellectual property rights of the Chinese medicinal materials,analyzes the poverty-stricken areas that are ecologically suitable for radix glycyrrhizae cultivation,and the superior counties and production bases of the Chinese medicinal ***,mainly from the aspects of perfect intellectual property rights,the establishment of authentic medicinal material production bases,and the construction of quality control systems,etc.,it discusses the rural revitalization strategy and the development strategy of traditional Chinese medicine(TCM),agricultural intellectual property protection and high-quality development strategy of radix glycyrrhizae.

关键词： radix glycyrrhizae New coronavirus disease(COVID-19) Effective drugs Chinese medicinal materials High quality development Rural revitalization strategy TCM development strategy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metabolomics of Fuzi-Gancao in CCl4 induced acute liver injury and its regulatory effect on bile acid profile in rats

引用

World Journal of Gastroenterology 2021年第40期27卷 6888-6907页

作者： Mo-Fei Wang Song-Song Zhao Dil Momin Thapa Yu-Ling Song Zheng Xiang The Second Department of General Surgery The Affiliated Hospital of Inner Mongolia University for the NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina Department of Educational Administration The First Affiliated Hospital of Liaoning Medical UniversityJinzhou 121000Liaoning ProvinceChina School of Pharmaceutical Science Liaoning UniversityShenyang 110032Liaoning ProvinceChina

BACKGROUND Fuzi(radix aconiti lateralis)-Gancao(radix glycyrrhizae)is one of the most classical drug pairs of traditional Chinese *** clinical practice,decoctions containing Fuzi-Gancao(F-G)are often used in the treatment of liver diseases such as hepatitis and liver *** To investigate the metabolomics of F-G in CCl4 induced acute liver injury in rats and its regulatory effect on the bile acid *** The pharmacodynamic effect of F-G on CCl4 induced acute liver injury in rats was evaluated,and an ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)method for the simultaneous determination of 92 metabolites from multiple pathways was established to explore the protective metabolic mechanism of F-G in serum on the *** Twenty-four differential metabolites were identified in serum *** primary bile acid biosynthetic metabolic pathway was the major common pathway in the model group and F-G ***,a UPLC-MS/MS method for simultaneous determination of 11 bile acids,including cholic acid,ursodeoxycholic acid,glycochenodeoxycholic acid,glycochenodeoxycholic acid,taurocholic acid,glycocholic acid,chenodeoxycholic acid,deoxycholic acid,taurochenodeoxycholic acid,taurocholic acid,and glycinic acid,was established to analyze the regulatory mechanism of F-G in serum.F-G decreased the contents of these 11 bile acids in serum in a dose-dependent manner compared with those in the model control *** F-G could protect hepatocytes by promoting the binding of free bile acids to glycine and taurine,and reducing the accumulation of free bile acids in the liver.F-G could also regulate the compensatory degree of taurine,decreasing the content of taurine-conjugated bile acids to protect hepatocytes.

关键词： radix aconiti lateralis radix glycyrrhizae Liver injury Metabolites Bile acid Fuzi-Gancao

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：