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Clinicopathological Characteristics and Prognostic Factors of Intrahepatic Biliary Cystadenocarcinoma

Chinese Medical Journal 2015年第9期128卷 1177-1183页

作者： Ming-Yue Xu Xian-Jie Shi Tao Wan Yu-Rong gang Hong-Guang Wang Wen-Zhi Zhang Lei He Ming-Yi Chen Shao-Cheng Lyu Wen-Wen Zhang Hui-Xing Li Department of Hepatobiliary Surgery People@s Liberation Army General Hospital Beijing 100853 China

Background：Surgical resection is generally considered the main curative treatment for intrahepatic biliary cystadenocarcinoma （IBCA） or suspected IBCAs,but controversy exists regarding the prognosis for IBCAs.This study aimed to describe the clinicopathological characteristics of IBCA and identify prognostic factors that may influence the survival of patients treated with surgical procedures.Methods：Thirty-four patients with histologically confirmed IBCA treated between January 2000 and June 2014 were included.The clinical characteristics of patients with IBCA were compared with those of 41 patients with intrahepatic biliary cystadenoma （IBC）;factors that significant difference were analyzed for prognosis analysis of IBCA using multivariate/univariate Cox proportional hazards regression models.Survival curves were constructed using the Kaplan-Meier method and compared using the log-rank test.Results：IBCAs had a strong female predominance,and the most common presenting symptoms were abdominal pain or discomfort.Compared with IBCs,IBCAs occurred in older patients,in more male patients,and were associated statistically significant abnormal increase in alanine aminotransferase （P =0.01） and total bilirubin （P =0.04）.Mural nodules were more frequently seen with IBCAs and may associate with malignancy.It was difficult to differentiate between IBC and IBCA based on laboratory examination and imaging findings.Although complete resection is recommended,enucleation with negative margins also achieved good outcomes.Median overall patient survival was 76.2 months;survival at 1,3,and 5 years was 88.0％,68.7％,and 45.8％,respectively.Radical resection and noninvasive tumor type were independent prognostic factors for overall survival.Conclusions：It remains difficult to distinguish between cystadenomas and cystadenocarcinomas based on laboratory examination and image findings.Complete resection is recommended for curative treatment,and patients should be closely followed postoperatively,particularly those with invasive tumors.

关键词： Intrahepatic Biliary Cystadenocarcinoma Intrahepatic Biliary Cystadenoma Liver Surgery Prognosis radiologic findings Survival

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Convalescent plasma therapy in a pregnant COVID-19 patient with a dramatic clinical and imaging response: A case report

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World Journal of Radiology 2020年第7期12卷 137-141页

作者： Ramezan Jafari Nematollah Jonaidi-Jafari Fatemeh Dehghanpoor Amin Saburi Radiology Department Faculty of Medicine and Chemical Injuries Research CenterBaqiyatallah University of Medical SciencesTehran 18151777Iran Health Research Center and Faculty of Medicine Baqiyatallah University of Medical SciencesTehran 18151777Iran Radiology Department Faculty of MedicineBaqiyatallah University of Medical SciencesTehran 18151777Iran Chemical Injuries Research Center and Faculty of Medicine Baqiyatallah University of Medical SciencesTehran 18151777Iran

BACKGROUND Coronavirus disease 2019(COVID-19)is a novel very contagious infection which was designated a pandemic in all countries of the world in April 2020.Its presentation varies from mild to severe infection,but the majority of infected patients have mild manifestations.Many therapeutic choices have been suggested to treat the infection,but none are fully effective.CASE SUMMARY Herein we present a 26-year-old woman with a twin pregnancy at 36 wk and one day gestation with confirmed COVID-19 who responded dramatically to convalescent plasma therapy(CPT)and Favipiravir.CONCLUSION Although this case report shows the efficacy of CPT in addition to usual medications used for COVID-19,there are many questions that need to be answered regarding dosage,para-clinical efficacy,side effects and combination therapy.

关键词： Case report Convalescent plasma therapy Pregnancy COVID-19 Favipiravir radiologic findings

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