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radioactive 125i seed implantation for pancreatic cancer with unexpected liver metastasis:A preliminary experience with 26 patients

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World Journal of Clinical Cases 2021年第4期9卷 792-800页

作者： Cheng-Gang Li Zhi-Peng Zhou Yu-Ze Jia Xiang-Long Tan Yu-Yao Song Second Department of Hepatobiliary Surgery Chinese PLA General HospitalBeijing 100853China

BACKGROUND Preoperative diagnosis rate of pancreatic cancer has increased year by year.The prognosis of pancreatic cancer patients with unexpected liver metastasis found by intraoperative exploration is very poor,and there is no effective and unified treatment strategy.AiM To evaluate the therapeutic effect of radioactive 125i seed implantation for pancreatic cancer patients with unexpected liver metastasis.METHODS The demographics and perioperative outcomes of patients who underwent 125i seed implantation to treat pancreatic cancer with unexpected liver metastasis between January 1,2017 and June 1,2019 were retrospectively analyzed.During the operation,125i seeds were implanted into the pancreatic tumor under the guidance of intraoperative ultrasound,with a spacing of 1.5 cm and a row spacing of 1.5 cm.For patients with obstructive jaundice and digestive tract obstruction,choledochojejunostomy and gastroenterostomy were performed simultaneously.After operation,the patients were divided into a non-chemotherapy group and a chemotherapy group that received gemcitabine combined with albumin-bound paclitaxel treatment.RESULTS Preoperative imaging evaluation of all patients in this study showed that the tumor was resectable without liver metastasis.There were 26 patients in this study,including 18 males and 8 females,aged 60.5±9.7 years.The most common tumor site was the pancreatic head(17,65.4%),followed by the pancreatic neck and body(6,23.2%)and pancreatic tail(3,11.4%).Fourteen patients(53.8%)underwent palliative surgery and postoperative pain relief occurred in 22 patients(84.6%).The estimated blood loss in operation was 148.3±282.1 mL and one patient received blood transfusion.The postoperative hospital stay was 7.6±2.8 d.One patient had biliary fistula,one had pancreatic fistula,and all recovered after conservative treatment.After operation,7 patients received chemotherapy and 19 did not.The 1-year survival rate was significantly higher in patients who received chemotherapy than in those who did not(68.6%vs 15.

关键词： Pancreatic cancer Liver metastases Radioactive 125I seeds Radiotherapy Permanent implantation Therapeutic effect

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CT导向下放射性125Ⅰ粒子组织间植入治疗肺癌临床研究

CT导向下放射性125Ⅰ粒子组织间植入治疗肺癌临床研究

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河南省首届肿瘤微创治疗学术会议暨河南省抗癌协会肿瘤微创...

作者：王庆国王振豫周建中周志刚江波陈学军郑州大学第一附属医院放射科

目的探讨CT导向下放射性粒子组织间植入治疗肺癌的技术方法、临床价值和短期疗效。方法对本组23例经活检病理证实的无法手术的肺癌患者,先利用TPS制定计划,然后在CT导向下经皮穿刺植入125i粒子,术后复查CT,详细记录布粒情况及有无并发... 详细信息

目的探讨CT导向下放射性粒子组织间植入治疗肺癌的技术方法、临床价值和短期疗效。方法对本组23例经活检病理证实的无法手术的肺癌患者,先利用TPS制定计划,然后在CT导向下经皮穿刺植入125i粒子,术后复查CT,详细记录布粒情况及有无并发症发生。而后每隔一个月复查CT,以观察疗效。结果短期总有效率95。8％(23／24), 其中CR20。8％(5／24),PR75％(18／24),NC4％(1／24),PD0％(0／24)。出现轻度并发症的 11例(45．8％),其中少量气胸4例(16．7％),少量出血6例(25％),粒子移位1例(4％)。复查病例均未发现放射性肺炎及骨髓抑制等严重并发症。结论CT导向下放射性125i粒子组织间植入治疗肺癌安全有效,并发症少,值得推广。

关键词： lung cancer Radioactive 125I seeds interstitial implantation CT guided

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