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Relationship between Whole Body iodine-131 Effective Half-Life and Estimated Glomerular Filtration Rate for Papillary Thyroid Cancer Patients Undergoing radioactive iodine therapy

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Journal of Applied Mathematics and Physics 2023年第8期11卷 2472-2479页

作者： Asim Abualnaja Hanaa Alsheikh Khaled Soliman Meshal Alnefaie Abdulraheem Alsheri Medical Physics Department Prince Sultan Military Medical City Riyadh Saudi Arabia Radiodiagnostics and Medical Imaging Department Prince Sultan Military Medical City Riyadh Saudi Arabia

Background: The aim of this work was to examine the relationship between the estimated glomerular filtration rate (eGFR) as indicator of renal efficiency potentially related to the ability to release radioactive iodine from the patients bodies and the radioactive iodine whole body effective half-life (WBEHL) defined as the time taken for the administered activity to decay to half of its value for papillary thyroid cancer (PTC) patients undergoing radioactive iodine therapy (RAIT) in a tertiary care medical Centre. Methods: This retrospective observational study included seventy nine patients, sixty females and nineteen males. The patients were divided in two subgroups, those who have WBEHL of less than 11 hours (n = 51) and those with more than 11 (n = 28) hrs based on k-means clustering technique. Results: Analysis of variance (ANOVA) was used to find out if there is a statistically significant difference between the two subgroups Conclusion: There was not a statistically significant difference between the short and the longer WBEHL patients’ groups analyzed in this study. .

关键词： GFR Thyroid Cancer radioactive iodine therapy Renal Function

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Rapid progression of heart failure secondary to radioactive iodine treatment of hyperthyroidism:A case report

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World Journal of Clinical Cases 2023年第22期11卷 5316-5321页

作者： Zi-Han Li Lu-Jia Ni Yuan-Qiao Liu Dao-Yuan Si Department of Cardiology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Jilin Provincial Engineering Laboratory for Endothelial Function China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Ultrasound China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

BACKGROUND The deterioration of thyroid health is involved in the progression of heart failure(HF).This is usually a lengthy process,so there are almost no reports on its rapid *** we report a case of a young male who rapidly developed hypothyroid cardiomyopathy secondary to radioactive iodine treatment,suggesting that severe HF might occur even after a short period of *** SUMMARY A 26-year-old man was referred to our hospital for HF presenting with dyspnea on exertion and chest discomfort lasting for 1 *** received radioactive iodine treatment for hyperthyroidism 1 year ago and had an almost normal echocardiogram 6 mo *** echocardiogram and cardiac magnetic resonance(CMR)revealed left ventricle(LV)global hypokinesia and severely depressed systolic *** addition,late gadolinium enhancement indicated no obvious changes in the *** function tests showed decreased serum levels of thyroid hormone(TH)and elevated thyroid-stimulating *** on an exclusionary examination,the patient was diagnosed with hypothyroid cardiomyopathy and was started on replacement *** HF symptoms were completely relieved during the six-month follow-up,and echocardiogram and CMR revealed recovered LV size and ejection *** This report demonstrates that severe fluctuations in TH levels may lead to acute HF,which can completely recover with timely thyroid hormone *** addition,our findings highlight the importance of routinely detecting cardiac function in patients treated with radioactive iodine.

关键词： Heart failure Hypothyroid cardiomyopathy Hormone replacement therapy radioactive iodine therapy Case report

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Capsaicin restores sodium iodine symportermediated radioiodine uptake through bypassing canonical TSH–TSHR pathway in anaplastic thyroid carcinoma cells

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Journal of Molecular Cell Biology 2021年第11期13卷 791-807页

作者： Shichen Xu Xian Cheng Jing Wu Yunping Wang Xiaowen Wang Liying Wu Huixin Yu Jiandong Bao Li Zhang NHC Key Laboratory of Nuclear Medicine Jiangsu Key Laboratory of Molecular Nuclear MedicineJiangsu Institute of Nuclear MedicineWuxi 214063China School of Food Science and Technology Jiangnan UniversityWuxi 214122China Department of Radiopharmaceuticals School of PharmacyNanjing Medical UniversityNanjing 211166China School of Life Science and Technology Southeast UniversityNanjing 210096China

Anaplastic thyroid cancer(ATC)is a rare but highly lethal *** are resistant to standard therapies and are extremely difficult to *** stepwise cell dedifferentiation results in the impairment of the iodine-metabolizing machinery and the infeasibility of radioiodine treatment in ***,reinducing iodine-metabolizing gene expression to restore radioiodine avidity is considered as a promising strategy to fight against *** the present study,capsaicin(CAP),a natural potent transient receptor potential vanilloid type 1(TRPV1)agonist,was discovered to reinduce ATC cell differentiation and to increase the expression of thyroid transcription factors(TTFs including TTF-1,TTF-2,and PAX8)and iodine-metabolizing proteins,including thyroidstimulating hormone receptor(TSHR),thyroid peroxidase,and sodium iodine symporter(NIS),in two ATC cell lines,8505C and ***,CAP treatment promoted NIS glycosylation and its membrane trafficking,resulting in a significant enhancement of radioiodine uptake of ATC cells in ***,CAP-activated TRPV1 channel and subsequently triggered Ca2þinflux,cyclic adenosine monophosphate(cAMP)generation,and cAMP-responsive element-binding protein(CREB)signal ***,CREB recognized and bound to the promoter of SLC5A5 to facilitate its ***,the TRPV1 antagonist CPZ,the calcium chelator BAPTA,and the PKA inhibitor H-89 effectively alleviated the redifferentiation exerted by CAP,demonstrating that CAP might improve radioiodine avidity through the activation of the TRPV1–Ca2þ/cAMP/PKA/CREB signaling *** addition,our study indicated that CAP might trigger a novel cascade to redifferentiate ATC cells and provide unprecedented opportunities for radioiodine therapy in ATC,bypassing canonical TSH–TSHR pathway.

关键词： anaplastic thyroid carcinoma capsaicin redifferentiation sodium iodine symporter radioactive iodine therapy

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