检索结果-南通市图书馆

radical addition and Substitution Reactions of (η6-Arene)-tricarbonylmetal Complexes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

有机化学 2003年第Z1期23卷 207-208页

作者： LIN He-Chun YANG Li LI Chao-Zhong State Key Laboratory of Applied Chemistry Lanzhou University Lanzhou 730000 State Key Laboratory of Applied Chemistry Lanzhou University Lanzhou 730000 Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032

　　We report here the first alkyl radical additions of (η6-arene)tricarbonylmanganese complexes in the presence of alkylmercury chloride and NaI (Eq. 1). The mechanism was postulated to be the alkyl radical addition to ArMn- (CO)+3 cation to form the corresponding 17 valence electron intermediate, which was then reduced by alkylmercury chloride via a single electron transfer process to afford the product and regenerate an alkyl radical. [1]……

关键词： electron transfer process valence electron radical addition

Cu-catalyzed radical addition Initiated Decarboxylative Functionalization

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cu-catalyzed Radical Addition Initiated Decarboxylative Func...

Direct synthesis of unnatural amino acids and modifications of peptides via LADA strategy

中国化学会·第十六届全国有机合成化学学术研讨会

作者： Guixia Liu Qiu Wang 王成明 College of Chemistry and Materials Science Jinan University Department of Chemistry Duke University 暨南大学

Carboxylic acids are pervasive in *** are low cost,stable and easy to *** a result,carboxylic acids are considered as ideal substrates for organic synthesis. In the past decades,transition-metal-catalyzed decarboxylative cross-coupling reactions have enjoyed tremendous advances owing to their widespread applications to the rapid assembly of diversified complex molecular structures,particularly in the fields of medicinal chemistry and material sciences. Herein,we disclosed a copper-catalyzed radical addition initiated sp-decarboxylative functionalization:alkylation,amination and sulfonylation.

关键词： copper radical addition decarboxylation Amination Alkylation Sulfonylation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第1期35卷 237-242页

作者： Yunqi Liu Junliang Zhou Zhankui Sun Shanghai Frontiers Science Center for Drug Target Identification and Drug Delivery School of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Pharm-X CenterSchool of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai 200240China AI Pharma Center Zhangjiang Institute for Advanced StudyShanghai Jiao Tong UniversityShanghai 201203China Shanghai Artificial Intelligence Laboratory Shanghai 200232China

Unnatural amino acids(UAAs)have broad applications in pharmaceutical sciences and biological *** synthetic methods for UAAs mainly rely on asymmetric catalysis and often require several *** is a lack of direct and simple *** address this challenge,we designed the LADA(labeling-activation-desulfurization-addition)strategy:selective labeling and activation of cysteine residues,the photocatalytic desulfurization and the subsequent radical addition to *** composed of two steps,it is one-pot synthesis and has advantages such as high functional group tolerance,biocompatible reaction condition,and retained *** highly efficient strategy was successfully applied in the direct synthesis of unnatural amino acids and modifications of peptides with more than 50 examples.

关键词： Unnatural amino acids Peptide modifications Desulfurization Cysteine radical addition

LADA strategy for the synthesis of unnatural amino acids and direct modifications of peptides

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2023年第6期66卷 1788-1794页

作者： Jun-Liang Zhou Yun-Qi Liu Zhan-Kui Sun Shanghai Frontiers Science Center for Drug Target Identification and Drug Delivery School of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Pharm-X CenterSchool of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai 200240China AI Pharma Center Zhangjiang Institute for Advanced StudyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Artificial Intelligence Laboratory Shanghai 200232China

Unnatural amino acids(UAAs)are important building blocks in organic synthesis and drug *** are also frequently integrated into peptides or proteins for biological ***,the direct and simplified synthesis of UAAs remains a great *** the same time,vast known peptide modifications are based on carbon-heteroatom *** are no general methods for peptide modifications via the construction of C–C *** address this challenge,herein we propose the LADA strategy,which is composed of two steps:the selective labeling and activation of cysteine residues,the desulfurization to generate carbon-centered radical and the radical addition to alkenes to build C–C *** one-pot protocol has obvious advantages such as good functional group tolerance,biocompatible reaction conditions,and retained *** strategy was successfully utilized for the synthesis of unnatural amino acids and direct modifications of peptides.

关键词： unnatural amino acids peptide modifications desulfurization cysteine radical addition

MODIFICATION OF NYLON-6 WITH POLYORGANOSILOXANE

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 1990年第3期8卷 234-239页

作者：袁强刘国民李光亮 Institute of Chemistry Academia Sinica Beijing

Nylon-6 has been modified by polyorganosiloxane. It was realized by radical addition of caprolactam to the vinyl group of silicone and anionic polymerization of the monomer in the presence of the silicone macromer. The mechanical properties of the modified plastics are not far from that of the unmodified one whereas its frictional properties are significantly improved.

关键词： Nylon Silicone radical addition Friction.

Synthesis of core-shell structured polymers with inserted thioether from a multi-functional scaffold

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第6期18卷 758-761页

作者： Pu, Hong Ting Zhou, Qing Wan, De Cheng Tongji Univ Sch Mat Sci & Engn Inst Funct Polymers Shanghai 200092 Peoples R China

The synthesis of a thioether inserted, core-shell structured polymer from the scaffold of hyperbranched polyglycerol (PG) was described. PG was first allyl functionalized, and in the presence of AlBN, the allyl groups further underwent radical addition to thiol compounds, thus thiol functional polyethylene oxide monomether (MPEO) were grafted onto PG. Similarly, 2-mercaptoethylammonium chloride was introduced onto PG via thiol addition, and the residual amino groups were further quaternized with decyl bromide, leading to an amphiphilic core-shell structure polymer. (c) 2007 De Cheng Wan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： core-shell scaffold thioether radical addition hyperbranched polymer