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Alzheimer's disease and low-dose radiation therapy:A new hope

radiation Medicine and Protection 2024年第1期5卷 1-6页

作者： Neal E.Dunlap Robert P.Friedland Lu Cai Department of radiation Oncology University of Louisville School of MedicineLouisvilleKY40202USA Department of Neurology The University of Louisville School of MedicineLouisvilleKY40202USA Pediatric Research Institute Departments of PediatricsPharmacology and ToxicologyUniversity of Louisville School of MedicineLouisvilleKY40202USA

The concept of low-dose radiation(LDR)-induced hormetic responses was initially observed approximately 70 years ago and systematically reviewed along with the discovery of LDR-induced adaptive responses in a cytogenetic in vitro study in *** the end of the 1990s,discussions regarding the potential applications of LDRinduced hormesis and adaptive responses for preventing or treating chronic diseases,such as Alzheimer’s disease(AD)had taken *** 2016,reports on radiotherapy for the subjects with AD and for genetic AD model mice were ***,several preclinical studies with animal models of AD and clinical studies in AD subjects were conducted.A significant milestone was achieved with the online availability of a new Systematic Review based on qualified publications from these preclinical and clinical *** mini-review provides a concise historical introduction to LDR-induced hormesis and adaptive responses with discussion of AD radiotherapy with either LDR or relatively high dose *** of this Systematic Review cover promising outcomes,challenges,and new questions,followed by discussion of potential mechanisms.

关键词： Alzheimer’s disease Low-dose radiation radiation adaptive response radiation hormesis

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COVID-19 and low-dose radiation therapy

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radiation Medicine and Protection 2021年第4期2卷 139-145页

作者： Neal E.Dunlap Victor van Berkel Lu Cai Department of radiation Oncology University of Louisville School of MedicineLouisvilleKY40202USA Department of Cardiovascular and Thoracic Surgery University of Louisville School of MedicineLouisvilleKY40202USA Pediatric Research Institute Departments of PediatricsPharmacology and ToxicologyUniversity of Louisville School of MedicineLouisvilleKY40202USA

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative pathogen of the coronavirus disease 2019(COVID-19),has caused more than 179 million infections and 3.8 million deaths *** health authorities working on the COVID-19 outbreak continue to explore methods to reduce the rate of its transmission to healthy *** protocols thus far have focused on social distancing and masking,treatment with antivirals early in infection,and steroids to reduce the inflammatory *** alternative approach is therapy with low dose radiation(LDR),which has several advantages compared to the current drugs and *** date more than 10 case reports and pilot clinical trial preliminary outcome are available from different *** reports cover a wide range of patient conditions and LDR treatment *** one report showed the failure to observe the improvement of COVID-19 patients after LDR therapy,the majority showed some clinical improvement,and demonstrated the safety of LDR for COVID-19 patients,particularly with 0.5 *** review aims to summarize the potential rationales and mechanisms of LDR therapy for COVID-19 patients,and its current clinical status and potential use.

关键词： Low dose radiation radiation hormesis Radiotherapy COVID-19 SARS-CoV-2

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