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Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups

World Journal of Gastroenterology 2015年第9期21卷 2759-2769页

作者： Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu Department of Family Medicine Research Division University of Kansas Medical CenterKansas CityKS 66160United States University of Kansas Cancer Center University of Kansas Medical Center Kansas CityKS 66160United States James Graham Brown Cancer Center and Department of Microbiology and Immunology University of LouisvilleLouisvilleKY 40202United States Department of Pharmacology Dalhousie UniversityHalifaxNS B3H 4R2Canada Department of Molecular and Integrative Physiology University of Kansas Medical CenterKansas CityKS 66160United States

AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White ***:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA ***,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the *** used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all ***:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic *** also found that participant microbial profiles differed by racial/ethnic *** Americans had significantly more Firmicutes than Whites,with enriched *** Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of *** also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in ***:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions.

关键词： Colorectal cancer Short chain fatty acids racial/e

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