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Efficacy of rabdosia rubescens in the Treatment of Gingivitis

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2009年第5期29卷 659-663页

作者：陈穗刘家荣张汉东 Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

This study evaluated the efficacy ofrabdosia rubescens against gingivitis and compared the therapeutic efficacy of different dosage forms of rabdosia rubescens. A multi-center, randomized, double-blind, double-simulation, positive-controlled and parallel trial was conducted. A total of 136 patients exhibiting clinical symptoms of gingivitis were enrolled. The subjects were randomly assigned to two groups： test group （n=67）, in which rabdosia rubescens drop pill （960 mg） and 4 tablets of simulation agent of rabdosia rubescen were orally given to the subjects three times a day for 5 days; and control group （n=69）, in which the subjects were administered the tablets of rabdosia rubescens （1000 mg） and 24 drop pills of simulation agent of rabdosia rubescens thrice daily for 5 days. The experimental protocols and diagnostic criteria were established by expert panel prior to the experiment. The clinical symptoms were graded according to the severity of the disease and quantified. The total scores and scores for each clinical symptom of gingivitis were assessed at baseline and on the 6th day post-treatment. The therapeutic efficacy was compared between the two groups and in each group itself before and after the treatment. The results showed that in the two groups, the subjects who were given rabdosia rubescens, drop pill or tablet, had a decrease in total scores and scores for each clinical symptom when compared with those before treatment （P〈0.01）. There was significant difference in the therapeutic efficacy between the test group and the control group with the efficacy rate being 92.54% and 79.71% respectively （P〈0.05）. It was concluded that rabdosia rubescens showed great promise in treating gingivitis. And rabdosia rubescens drop pill was more efficacious than rabdosia rubescens tablet.

关键词： rabdosia rubescens drop pill tablet gingivitis

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A New Asymmetric ent-Kauranoid Dimer from rabdosia rubescens

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Chinese Herbal Medicines 2012年第1期4卷 4-7页

作者： Hai-ying LU Jing-yu LIANG Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

Objective To study the ent-kaurane diterpenoids from rabdosia rubescens. Methods The compounds were isolated by chromatographies and their structures were identified by spectral analyses. Results Four compounds were isolated, and they were identified as bisrubescensin E (1), 2α,3α,24-trihydroxyurs-12-en-28-oic acid (2), 2α,3α,24-trihydroxyurs-12,20-(30)-dien-28-oic acid (3), and 6,7-dihydroxycoumarin (4). Conclusion Compound 1 is a new asymmetric ent-kauranoid dimer. Compound 2 is isolated from the plant for the first time. Compounds 3 and 4 are isolated from the plants of rabdosia (Bl.) Hassk for the first time.

关键词： asymmetric ent-kauranoid dimer coumarin diterpenoid rabdosia rubescens triterpenoid

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Hepatotoxicity and nephrotoxicity of the alcoholic extract from Rabodasia rubescens

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中国药理学与毒理学杂志 2013年第3期 497-498页

作者： LI Yin-chao HE Yong-xia SUN Man CHEN Hui-fang XU Ping-hua WANG Sui-hua LIU Hong-min Research Center of Zhengzhou University Drug Safety Evaluation

OBJECTIVE Giving the alcoholic extract from rabdosia rubescens through ig administration for 30 d,observing whether it occurs accumulation toxicity of liver and kidney in rats,and providing a reference for the follow-up safety *** Observing the requirements of the second draft of Chinese medicine,and natural drug long-term toxicity research technology guidance principles under([Z]GPT 3-1),select 80 large rats,female and male the half,physique volume(200 ± 20) *** were divided into 4 groups by weight tiered random,that is rabdosia rubescens alcohol extracts high,medium and low dose groups and dissolved vector controlled *** were 10 female and male animals in each *** rats were administered to give the rabdosia rubescens alcohol extract 0.96 g·kg-1(equivalent to native herbs 20.84 g·kg-1),0.71 g·kg-1(equivalent to native herbs 15.41 g·kg-1),0.46 g·kg-1(equivalent to native herbs 9.99 g·kg-1) *** administration continuously for 30 d and recovery 14 *** the end of the medication and recovery period,one-second of male and female animals in each group were killed to have blood biochemical examinations and system autopsy and histopathological examination and record the rats' general condition,body weight,food *** Except a male death of the high dose group,there was no animal death in other *** the administration,the high and medium does of the rabdosia rubescens alcohol extracts can make the rats lose weight,react slowly and erect *** rabdosia rubescens alcohol extracts low dose group and dissolved vector controlled group,the rats are generally in good *** blood biochemical index(ALT,BUN) levels of male rats in the rabdosia rubescens alcohol extracts high dose group and the blood biochemical index(BUN) levels of female rats in the medium does all rise significantly higher(P < 0.05) than that of the dissolved vector controlled *** the end of the medication,compared to the dissolved vector

关键词： rabdosia rubescens alcoholic extract hepatic toxicity renal

Hepatotoxicity and nephrotoxicity of the alcoholic extract from Rabodasia rubescens

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Hepatotoxicity and nephrotoxicity of the alcoholic extract f...