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Effect of dexamethasone by local treatment on cerebral edema and serum myelin basic protein after brain injury in rabbits

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Chinese Journal of Traumatology 2000年第4期3卷 231-233页

作者：杨波关方霞刘婉华宋来君 Department of Neurosurgery The First Affiliated HospitalHenan Medical University Albert Einstein College of Medicine of Yeshive University The Physics Department of Henan Medical University

To explore the effect of dexamethasone by local treatment on cerebral edema and brain damage after brain injury. Methods: Twenty-two rabbits were classified into 2 groups, Group A (the control group, n=11) and Group B (the treated group, n=11). An rabbit brain contusion model was made by bone windowplasty by extradural hitting. Group B was treated by local infiltrating and spraying of dexamethasone at equidistance to lesions. Group A was given normal saline in the same way as Group B. The changes of moisture in brain tissues and serum myelin basic protein (MBP) were observed. Results: The percentage of water content in damaged hemisphere in Group A and Group B was 81.75 %± 0.56 % and 79.45 %± 0.52 % respectively. There was a significant difference between the 2 groups (P< 0.05 ). The normal level of MBP was 1.66 μg/L± 0.71 μg/L, while the value of MBP in Group A and Group B were 5.98 μg/L± 2.08 μg/L and 3.15 μg/L± 1.09 μg/L separately. The level of MBP in Group A and Group B were higher than normal level and there was also a significant difference between Group A and Group B (P< 0.05 ). Conclusions: The results of our study showed that the brain moisture and MBP in serum were increased after brain injury while reduced after treatment with dexamethasone. It is demonstrated that local treatment of brain injury with dexamethasone has an obvious therapeutic effect on cerebral edema and serum MBP.

关键词： Brain injuries Cerebral cortex Dexamethasone Cerebral edema Encephalitogenic basic proteins rabbits@

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