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Ribophorin II is a substrate of spermatid-specific E3 ligase RNF148

Ribophorin II is a substrate of spermatid-specific E3 ligase...

引用

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Wei Zhang~(1,2),Zhenyu Xiao~(1,2),Chunsheng Han~1 1.State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China 2.Graduate University of Chinese Academy of Sciences,Beijing 100039,China

Ring finger proteins(RNFs) are a subfamily of zinc finger proteins and many of them function as ubiquitin ligases(E3s).Many RNFs are germ cell-specifically expressed and play important roles in spermatogenesis. Previously,we have shown that RNF133 is a testis-specific endoreticulum-associated *** this study,we show that another spermatid-specific gene Rnf148,located 5k-bp upstream of Rnfl33,also encodes an E3 with similar protein domains including a signal peptide,a protease-association domain,a transmembrane domain and a C3HC4 RING finger *** vitro assays showed that RNF148 worked with ubiquitin-conjugating enzymes(E2s) such as UbcH5b and UbcH7,which is involved in endoreticulum associated degradation(ERAD) ***148 co-localized with the reticulum-associated E2 MmUbc6, and co-immunoprecipitated with CD3-.which is a typical substrate in ERAD *** two-hybrid screening revealed that RNF148 physically interacts with ribophorin II(rpnii),which is a component of ***-immunoprecipitation and cycloheximide treatment experiments confirmed that rpnii is not only a partner but also a substrate of *** was highly expressed in spermatogonia and spermatocytes,in which RNF148 was *** negative correlation of the expression of RNF148 and rpnii in mouse testis implied that rpnii is targeted by RNF148 for degradation in *** rpnii is involved in the biosynthesis process of N-glycans on glycoproteins, which has been reported to play key roles in germ cell-Sertoli cell attachment,we propose that RNF148 may inhibit the synthesis of glycoproteins through the degradation of rpnii resulting in the dissociation of germ cell from Sertoli cells and their release into the seminiferous tubules.

关键词： RNF148 rpnii RING E3 ligase ubiquitination spermatogenesis

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