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Chlorella sp.-ameliorated undesirable microenvironment promotes diabetic wound healing

Acta Pharmaceutica Sinica B 2023年第1期13卷 410-424页

作者： Hangyi Wu Pei Yang Aiqin Li Xin Jin Zhenhai Zhang HuiXia Lv Department of Pharmaceutics China Pharmaceutical UniversityNanjing 211198China The Affiliated Suqian First People's Hospital of Nanjing Medical University Suqian 223800China Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210023China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210028China

Chronic diabetic wound remains a critical challenge suffering from the complicated negative microenvironments,such as high-glucose,excessive reactive oxygen species(ros),hypoxia and malnutrition.Unfortunately,few strategies have been developed to ameliorate the multiple microenvironments simultaneously.In this study,Chlorella sp.(Chlorella)hydrogels were prepared against diabetic wounds.In vitro experiments demonstrated that living Chlorella could produce dissolved oxygen by photosynthesis,actively consume glucose and deplete ros with the inherent antioxidants,during the daytime.At night,Chlorella was inactivated in situ by chlorine dioxide with human-body harmless concentration to utilize its abundant contents.It was verified in vitro that the inactivated-Chlorella could supply nutrition,relieve inflammation and terminate the oxygen-consumption of Chlorella-respiration.The advantages of living Chlorella and its contents were integrated ingeniously.The abovementioned functions were proven to accelerate cell proliferation,migration and angiogenesis in vitro.Then,streptozotocininduced diabetic mice were employed for further validation.The in vivo outcomes confirmed that Chlorella could ameliorate the undesirable microenvironments,including hypoxia,high-glucose,excessiveros and chronic inflammation,thereby synergistically promoting tissue regeneration.Given the results above,Chlorella is considered as a tailor-made therapeutic strategy for diabetic wound healing.

关键词： Chlorella sp. Diabetic wound healing Oxygen production Glucose consumption ros depletion Nutrition supplement Anti-inflammation

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