检索结果-南通市图书馆

Association between risk factors and retinal nerve fiber layer loss in early stages of diabetic retinopathy

International Journal of Ophthalmology(English edition) 2021年第2期14卷 255-262页

作者： Zhong-Qi Wan Yan Gao Min Cui Yong-Jie Zhang School of Public Health Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina Department of Vitreoretinology Shanxi Eye HospitalTaiyuan 030005Shanxi ProvinceChina Department of Human Anatomy Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

AIM:To investigate the changes of retinal nerve fiber layer(rnfl)among normal individuals,diabetic patients without diabetic retinopathy(NDR)and non-proliferative diabetic retinopathy(NPDR),and explore the possible risk factors of early diabetic retinopathy(DR).METHODS:In this cross-sectional study,107 participants were divided in three *** 31 normal individuals(control group),40 diabetic patients without DR(NDR group)and 36 patients with NPDR(NPDR group)were *** coherence tomography(OCT)was used to detect rnfl thickness and other optic disc parameters among different *** potential association between rnfl loss and systemic risk factors were assessed for DR,including diabetes duration,body mass index(BMI),hemoglobin A1 c(Hb A1 c),serum lipids,and blood ***:The average and each quadrant rnfl thickness were thinner in NPDR group compared to control group of the right(P=0.00,P=0.01,P=0.01,P=0.02,P=0.04)and left eyes(P=0.00,P=0.00,P=0.00,P=0.03,P=0.04).The average,superior and inferior rnfl thickness were thinner in NDR group compared to the NPDR group of the right(P=0.00,P=0.02,P=0.03)and left eyes(P=0.00,P=0.00,P=0.01).Diabetic duration was negatively correlated with the superior,inferior,and average rnfl thickness of the right(r=-0.385,P=0.001;r=-0.366,P=0.001;r=-0.503,P=0.000)and left eyes(r=-0.271,P=0.018;r=0.278,P=0.015;r=-0.260,P=0.023).Hb A1 c was negatively correlated with the superior,inferior,and average rnfl thickness of the right(r=-0.316 P=0.005;r=-0.414,P=0.000;r=-0.418,P=0.000)and left eyes(r=-0.367,P=0.001;r=-0.250,P=0.030;r=-0.393,P=0.000).Systolic pressure was negatively correlated with the inferior and average rnfl thickness of the right eye(r=-0.402,P=0.000;r=-0.371,P=0.001)and was negatively correlated with the superior and average rnfl thickness of the left eye(r=-0.264,P=0.021;r=-0.233,P=0.043).CONCLUSION:rnfl loss,especially in the superior and inferior quadrants,may be the earliest structural change o

关键词： diabetic retinopathy rnfl less neurodegeneration risk factors optical coherence tomography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：