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Antiviral Effect of Ribonuclease from <i>Bacillus pumilus</i>against Phytopathogenic rna-viruses

Agricultural Sciences 2015年第11期6卷 1357-1366页

作者： Margarita Sharipova Annett Rockstroh Nelly Balaban Ayslu Mardanova Anna Toymentseva Anastasiya Tikhonova Semen Vologin Zenon Stashevsky Kazan (Volga Region) Federal University Kazan Russia Tatar Research Institute of Agriculture Kazan Russia

Background: viruses can cause different diseases in plants. To prevent viral infections, plants are treated with chemical compounds and antiviral agents. Chemical antiviral agents usually have narrow specificity, which limits their wide application. Alternative antiviral strategy is associated with the use of microbial enzymes, which are less toxic and are readily decomposed without accumulation of harmful substances. The aim of this work is to study the effect of Bacillus pumilus ribonuclease on various phytopathogenic viruses with specific focus on the ability of enzyme to eliminate them from plant explants in vitro. Materials and methods: Extracellular ribonuclease of B. pumilus is tested as an antiviral agent. To study the antiviral effect of rnase, depending on concentration and the time of application several plant-virus model systems are used. Virus detection is conducted by serological testing and RT-PCR. Results: Bacillus pumilus ribonuclease possesses antiviral activity against plant rna-viruses RCMV (red clover mottle virus), PVX (Potato Virus X) and AMV (Alfalfa Mosaic Virus). The maximum inhibitory effect against actively replicating viruses is observed when plants are treated with the enzyme in the concentration of 100 ug/ml prior to infection. In case of local necrosis ribonuclease in the concentration of 1 ug/ml completely inhibits the development of RCMV virus on bean plants. The enzyme is able to penetrate plants and inhibit the development of viral infection, inhibiting effect for untreated surfaces decreased on average for 20%. It is also found that B. pumilus ribonuclease protects apical explants of sprouts of potato tubers from PVM and PVS viruses. Conclusion: B. pumilus ribonuclease possesses antiviral activity against plant rna-viruses and produces viruses-free plants in the apical meristem culture.

关键词： Bacillus Pumilus Ribonuclease Phytopathogenic rna-viruses Inhibition Virus-Free Apical

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Is COVID-19-induced liver injury different from other rna viruses?

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World Journal of Meta-Analysis 2021年第2期9卷 108-127页

作者： Marwan SM Al-Nimer Department of Clinical Pharmacy Hawler Medical UniversityErbil 44001Iraq College of Medicine University of DiyalaBaqubah 32001Iraq

Coronavirus disease 2019 is a pandemic disease caused by a novel rna coronavirus,SARS coronavirus 2(SARS-CoV-2),which is implicated in the respiratory ***-CoV-2 also targets extrapulmonary systems,including the gastrointestinal tract,liver,central nervous system and ***-CoV-2,like other rna viruses,targets the liver and produces liver *** literature review showed that SARS-CoV-2-induced liver injury is different from other rna viruses by a transient elevation of hepatic enzymes and does not progress to liver fibrosis or other unfavorable ***,SARS-CoV-2-induced liver injury usually occurs in the presence of risk factors,such as nonalcoholic liver fatty *** review highlights the important differences between rna viruses inducing liver injury taking into consideration the clinical,biochemical,histopathological,postmortem findings and the chronicity of liver injury that ultimately leads to liver fibrosis and hepatocellular carcinoma.

关键词： Liver injury COVID-19 rna-viruses Risk factors Liver enzymes Liver fibrosis

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