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relationship of ldlr gene polymorphism and niddm in chinese

chinese Medical Journal 1995年第1期108卷 10-14页

作者：吴松华项坤三孙多奇王延庆浦流陆惠娟 Department of Endocrinology and Metabolism Medical Genetics Laboratory Shanghai Sixth People's Hospital Shanghai 200233

Genomic DNA was extracted from peripheral blood lymphocytes of 105 healthy and 75 niddm chinese subjects, The fragment located in exon 13 of the low density lipoprotein receptor (ldlr) gene was amplified by polymerase chain reaction (PCR), and digested with restriction enzyme HincII, LDL, TC and TG levels were measured in all subjects, investigations were conducted to explore the correlation between the HincII RFLP of ldlr gene aned niddm in the chinese population. The results showed that no significant correlation existed between this RFLP locus and niddm. Marked differences were found, however, between the genotype distribution of low LDL level subgroups of niddm patients and normal controls. It was inferred that the H1 allele might be associated with high blood cholesterol levels, and the H2 allele with low cholesterol levels. Disturbances of lipid metabolism occur frequently in diabetes mellitus. This study suggested that differences in ldlr genotypes may affect the phenotypes of lipid metabolism.

关键词： niddm relationship of ldlr gene polymorphism and niddm in chinese ldlr

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