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China Communications 2023年第3期20卷 218-235页

作者： Nan Li Qi Sun Xiang Li Fengxian Guo Yuhong Huang Ziqi Chen Yiwei Yan Mugen Peng China Mobile Research Institute Beijing 100053China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

To accommodate the diversified emerging use cases in 5G,radio access networks(ran)is required to be more flexible,open,and *** is evolving towards cloudification,intelligence and *** embedding computing capabilities within ran,it helps to transform ran into a natural cost effective radio edge computing platform,offering great opportunity to further enhance ran agility for diversified services and improve users’quality of experience(Qo E).In this article,a logical architecture enabling deep convergence of communication and computing in ran is proposed based on *** scenarios and potential benefits of sharing ran computing resources are first ***,the requirements,design principles and logical architecture are *** key technologies are also discussed,including heterogeneous computing infrastructure,unified computing and communication task modeling,joint communication and computing orchestration and ran computing data *** by that,a VR use case is studied to illustrate the superiority of the joint communication and computing ***,challenges and future trends are highlighted to provide some insights on the potential future work for researchers in this field.

关键词： ran computing resource sharing com-munication and computing joint design

Prognostic potential of the small GTPase ran and its methylation in hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2022年第3期21卷 248-256页

作者： Hui-Hui Liu Ju Wang Ying Zhang Yu-Chen Fan Kai Wang Department of Hepatology Qilu Hospital of Shandong UniversityJinan 250000China Shenzhen Research Institute of Shandong University Shenzhen 518000China Institute of Hepatology Shandong UniversityJinan 250000China

Background: Hepatocellular carcinoma(HCC) is a common malignant tumor with high mortality. The prognostic significance of ran, a member of Ras superfamily, remains unclear in HCC patients. Methods: Based on The Cancer Genome Atlas(TCGA) database and Tumor Immune Estimation Resource(TIMER), we analyzed the correlations among ran expression, promoter methylation and immune cell infiltration. We also investigated the ran expression levels in HCC tissues and normal tissues by using quantitative real-time PCR. Results: ran m RNA expression was significantly increased in HCC tissues compared with the normal tissues( P ran expression had predictive value of the 1-, 3-and 5-year overall survival for HCC patients, and the areas under the curves(AUC) were 0.747, 0.634 and 0.704, respectively. Cox regression analysis showed that ran expression was an independent prognostic factor for HCC patients(HR = 1.492, 95% CI: 1.129-1.971, P = 0.005). We also found a negative relationship between ran m RNA expression and its promoter methylation( r =-0.36, P ran expression and promoter hypomethylation predicted worse overall survival and progression-free survival( P ran expression exhibited significant correlations with immune infiltrates and prognostic immune-related genes. Conclusions: The present study provides further insight into the prognosis of HCC, and ran could serve as a biomarker for predicting the survival of HCC patients.

关键词： Hepatocellular carcinoma ran Methylation Prognosis Immune cell infiltration

Role of ran GTPase in cell cycle regulation

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Chinese Science Bulletin 2004年第6期49卷 535-541页

作者： JIANGQing LUZhigang ZHANGChuanmao DepartmentofCellBiologyandGenetics.NationalKeyLaboratoryofBiomembraneandMembraneBiotechnology CollegeofLifeSciencesPekingUniversityBeijing100871China

ran, a member of the Ras GTPase superfamily, is a multifunctional protein and abundant in the nucleus. Many evidences suggest that ran and its interacting proteins are involved in multiple aspects of the cell cycle regulation. So far it has been conformed that ran and its interacting proteins control the nucleocytoplasmic transport, the nuclear envelope (NE) assembly, the DNA replication and the spindle assembly, although many details of the mechanisms are waiting for elucidation. It has also been implicated that ran and its interacting proteins are involved in regulating the integrity of the nuclear structure, the mRNA transcription and splicing, and the RNA transport from the nucleus to the cytoplasm. In this review we mainly discuss the mechanisms by which ran and its interacting proteins regulate NE as-sembly, DNA replication and spindle assembly.

关键词： ran GTPase 细胞循环 DNA复制纺锤体集成细胞核细胞膜 G蛋白

A Fully-Decoupled ran Architecture for 6G Inspired by Neurotransmission

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Journal of Communications and Information Networks 2019年第4期4卷 15-23页

作者： Quan Yu Haibo Zhou Jiacheng Chen Ying Li Jian Jing Jiwei(Jackokie)Zhao Bo Qian Jian Wang Peng Cheng Laboratory Shenzhen 518000China School of Electronic Science and Engineering Nanjing UniversityNanjing 210023China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China

While the commercial deployment and promotion of 5G is ongoing,mobile communication networks are still facing three fundamental challenges,i.e.,spectrum resource scarcity,especially for low-frequency spectrum,exacerbated by fragmented spectrum allocation,user-centric network service provision when facing billions of personalized user demands in the era of Internet of everything(IoE),and proliferating operation costs mainly due to huge energy consumption of network *** address these issues,it is imperative to consider and develop disruptive technologies in the next generation mobile communication networks,namely *** this paper,by studying brain neurons and the neurotransmission,we propose the fully-decoupled radio access network(FD-ran).In the FD-ran,base stations(BSs)are physically decoupled into control BSs and data BSs,and the data BSs are further physically split into uplink BSs and downlink *** first review the fundamentals of neurotransmission and then propose the 6G design principles inspired by the *** on the principles,we propose the FD-ran architecture,elastic resource cooperation in FD-ran,and improved transport service layer *** proposed fully decoupled and flexible architecture can profoundly facilitate resource cooperation to enhance the spectrum utilization,reduce the network energy consumption and improve the quality of user *** research topics in this direction are envisioned and discussed.

关键词： 6G architecture design ran neural net-work neurotransmission

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ran网络及其应用的研究

仪器仪表学报 2001年第1期22卷 13-16页

作者：武星军朱世强金波浙江大学流体传动及控制国家重点实验室杭州310027

ran(Resource Allocating Network)是一种基于径向基函数的单隐含层神经网络 ,开始时无隐含节点 ,可根据新颖性准则来决定是否增加隐含节点 ,故有效避免了网络结构 (隐含节点个数 )和初始网络参数难以选取的缺点。本文首先利用 ran得到... 详细信息

ran(Resource Allocating Network)是一种基于径向基函数的单隐含层神经网络 ,开始时无隐含节点 ,可根据新颖性准则来决定是否增加隐含节点 ,故有效避免了网络结构 (隐含节点个数 )和初始网络参数难以选取的缺点。本文首先利用 ran得到网络的初始结构及参数 ,然后利用扩展的卡尔曼滤波器 EKF(Extended Kalman Filter)算法对网络参数进行调整 ,这相当于在粗调的基础上对网络参数进行细调。该网络具有学习速度快、精确度高、结构紧凑的优点。

关键词： ran 径向基函数新颖性准则隐含节点扩展卡尔曼滤波器算法神经网络

小麦ran1在酵母系统中影响微管的完整性和核质运输过程

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Acta Botanica Sinica 2004年第8期46卷 940-947页

作者：王昕韩晔陈昌斌种康许智宏中国科学院植物研究所光合与分子生理学重点实验室，分子与发育生物学研究中心，北京100093

真核生物的小G蛋白ran在进化过程中比较保守，它可直接参与细胞周期调控过程，它的缺失突变可以影响很多细胞生理进程。我们已经从小麦(Triticumaestivum *** No．1)cDNA文库中克隆到一个新的ran GTPase的同源基因Taran1。在此基础上利... 详细信息

真核生物的小G蛋白ran在进化过程中比较保守，它可直接参与细胞周期调控过程，它的缺失突变可以影响很多细胞生理进程。我们已经从小麦(Triticumaestivum *** No．1)cDNA文库中克隆到一个新的ran GTPase的同源基因Taran1。在此基础上利用裂殖酵母模式系统研究了该基因的功能。研究结果表明，Taran1基因超表达可产生缺陷的纺锤体微管，这可能是导致我们以前观察到的异常染色体分离现象的原因。反义Taran1基因表达的酵母细胞，微管系统受到破坏。我们推测Taran1蛋白在细胞有丝分裂的纺锤体组装和维持微管系统的完整与稳定过程中起着重要作用。透射电镜观察实验结果显示，超表达Taran1的酵母细胞具有异常的核膜结构，反义表达Taran1的酵母细胞有异常的液泡结构和紊乱的膜结构，由此推测，Taran1在整个核质运输事件中可能是必须的。

关键词：小麦 ran1 微管核质运输有丝分裂裂殖酵母 ran GTP酶

多发性骨髓瘤细胞中P53介导的ran转录调控的研究

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中国实验血液学杂志 2016年第3期24卷 760-764页

作者：袁磊谷振阳高春记解放军医学院解放军总医院血液科北京100853

目的:探讨P53是否在骨髓瘤细胞中对ran进行转录调控。方法:应用实时荧光定量PCR检测多发性骨髓瘤细胞系OPM-2、RPMI-8226、U-266、KAS6/1、ANML-6、H-929、MM1.S、MOLP-8中ran转录水平,使用Nutlin-3a培养骨髓瘤细胞株MM1.S 24、48和72 ... 详细信息

目的:探讨P53是否在骨髓瘤细胞中对ran进行转录调控。方法:应用实时荧光定量PCR检测多发性骨髓瘤细胞系OPM-2、RPMI-8226、U-266、KAS6/1、ANML-6、H-929、MM1.S、MOLP-8中ran转录水平,使用Nutlin-3a培养骨髓瘤细胞株MM1.S 24、48和72 h后检测ran转录水平;蛋白免疫印迹方法检测ran和P53蛋白表达水平;使用不同剂量的表达P53荧光素酶报告基因质粒转染MM1.S细胞后检测ran表达水平。结果:在8株人骨髓瘤细胞株中H-929和MM1.S细胞中ran的转录活性最高,其差异具有统计学意义(Pran转录水平较空白对照组明显下降(Pran蛋白表达减少(r=-1.00,P=0.04)。表达P53荧光素酶报告基因的质粒转染MM1.S细胞后发现,在质粒增加至25 ng后ran转录水平开始下降(Pran转录水平的实验证明了ran是受p53调控的一个靶基因。

关键词： P53 ran 多发性骨髓瘤转录调控

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四川大学学报（医学版） 2017年第6期48卷 880-885页

作者：符梅许文明覃太周徐克惠四川大学华西第二医院四川大学-香港中文大学生殖医学联合实验室生殖内分泌科成都610041 出生缺陷与相关妇儿疾病教育部重点实验室(四川大学) 成都610041 绵阳市第三人民医院妇科绵阳621000 成都市妇女儿童医院妇产科成都610041

目的探讨miRNA成熟关键基因DICER、DROSHA和ran的基因多态性与女性复发流产的相关性。方法收集2013年6月至2015年12月于四川大学华西第二医院就诊的不明原因复发流产(URSA)患者共217例,至少有1次生育史的育龄妇女为正常对照组390例,对... 详细信息

目的探讨miRNA成熟关键基因DICER、DROSHA和ran的基因多态性与女性复发流产的相关性。方法收集2013年6月至2015年12月于四川大学华西第二医院就诊的不明原因复发流产(URSA)患者共217例,至少有1次生育史的育龄妇女为正常对照组390例,对照组为同期进行体检和孕前检查育龄妇女。采用病例对照研究的方法,应用PCR-限制性片段长度多态性技术检测miRNA成熟过程中关键基因DICER rs3742330、DROSHArs10719和ran rs14035单核苷酸多态性。结果 DICERrs3742330,DROSHArs10719和ranrs14035各等位基因和基因型频率在URSA组和对照组差异无统计学意义(P>0.05)。联合分析发现,DICERrs3742330/DROSHArs10719GG/TT+TC协同会增加复发流产的风险(OR=1.657,95%CI=1.006~2.731,P=0.047)。虽然DICERrs3742330/ranrs14035GG/TT+TC在URSA组较对照组增高,但差异无统计学意义(OR=1.977,95%CI=0.956~4.087,P=0.066),而DROSHA10719/ran14035TT+TC/TT+TC与复发流产无相关性(OR=0.958,95%CI=0.679~1.353,P=0.808)。结论DICERrs3742330联合DROSHA rs10719可能与URSA相关。

关键词： DICER DROSHA ran 基因多态性复发流产

ran promotes the proliferation and migration ability of head and neck squamous cell carcinoma cells

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Ran promotes the proliferation and migration ability of head...

ran1基因过表达抑制嗜热四膜虫大核无丝分裂

2020年全国口腔颌面-头颈肿瘤学术大会暨中华口腔医学会口腔颌面-头颈肿瘤专业委员会学术年会——创新超越、共赢未来

作者： Chong Zhang Fayu Liu China Medical University

Purpose/Background:HNSCC is an aggressive tumor that often recurrence and metastasis. Although the treatment of HNSCC has improved over the past few decades, it is easy to recurrence even after comprehensive treatment. ran is a small Ras-related GTPase belonging to the Ras superfamily. Recently, ran has been proven to be an important oncogene involved in the metastatic progression of many human cancers. But there is seldom research on HNSCC about ran.

关键词： ran proliferation migration head and neck squamous cell carcinoma cells

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中国生物化学与分子生物学报 2013年第1期29卷 42-48页

作者：梁海霞许静王伟山西大学生物技术研究所化学生物学与分子工程教育部重点实验室太原030006

ran GTPase通过ranGTP/ranGDP循环的形式,参与调控多种细胞增殖方式:包括有丝分裂和减数分裂.敲减ran1基因可导致嗜热四膜虫大核内微管组装紊乱,从而抑制大核无丝分裂.为进一步分析ran1在无丝分裂中的功能,本研究将野生型ran1以及模拟GT... 详细信息

ran GTPase通过ranGTP/ranGDP循环的形式,参与调控多种细胞增殖方式:包括有丝分裂和减数分裂.敲减ran1基因可导致嗜热四膜虫大核内微管组装紊乱,从而抑制大核无丝分裂.为进一步分析ran1在无丝分裂中的功能,本研究将野生型ran1以及模拟GTP(ran1Q70L)和GDP(ran1T25N)锁定形式的ran1突变体在嗜热四膜虫中过量表达,均导致四膜虫细胞增殖速率下降,并引起大核无丝分裂异常,且这种核异常细胞比率与ran1过表达量呈正相关.免疫荧光定位结果显示,过表达的HA-ran1在整个细胞中弥散分布,破坏了正常的ran1分布形式;而过表达的HA-ran1Q70L明显集中在大核核膜和胞质中,HA-ran1T25N则主要定位在大核和小核内,分别与ran1GTP/ran1GDP循环的辅助调节因子定位模式一致.以上结果表明,过表达ran1及其突变体可能影响嗜热四膜虫细胞中正常的ran1GTP/ran1GDP循环,进而导致大核无丝分裂异常.

关键词： ran GTPase 无丝分裂嗜热四膜虫