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quorum sensing regulation methods and their effects on biofilm in biological waste treatment systems: A review

Frontiers of Environmental Science & Engineering 2022年第7期16卷 47-59页

作者： Zhuqiu Sun Jinying Xi Chunping Yang Wenjie Cong Environmental Simulation and Pollution Control State Key Joint Laboratory School of EnvironmentTsinghua UniversityBeijing100084China State Environmental Protection Key Laboratory of Microorganism Application and Risk Control(SMARC) Beijing100084China Guangdong Provincial Key Laboratory of Petrochemical Pollution Processes and Control School of Environmental Science and EngineeringGuangdong University of Petrochemical TechnologyMaoming525099China College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangsha410082China

quorum sensing (QS) plays an important role in microbial aggregation control. Recently, the optimization of biological waste treatment systems by QS regulation gained an increasing attention. The effects of QS regulation on treatment performances and biofilm were frequently investigated. To understand the state of art of QS regulation, this review summarizes the methods of QS enhancement and QS inhibition in biological waste treatment systems. Typical QS enhancement methods include adding exogenous QS molecules, adding QS accelerants and cultivating QS bacteria, while typical QS inhibition methods include additions of quorum quenching (QQ) bacteria, QS-degrading enzymes, QS-degrading oxidants, and QS inhibitors. The specific improvements after applying these QS regulation methods in different treatment systems are concluded. In addition, the effects of QS regulation methods on biofilm in biological waste treatment systems are reviewed in terms of biofilm formation, extracellular polymeric substances production, microbial viability, and microbial community. In the end, the knowledge gaps in current researches are analyzed, and the requirements for future study are suggested.

关键词： quorum sensing Biological waste treatment Biofilm formation

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quorum sensing-based interactions among drugs,microbes,and diseases

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Science China(Life Sciences) 2023年第1期66卷 137-151页

作者： Shengbo Wu Shujuan Yang Manman Wang Nan Song Jie Feng Hao Wu Aidong Yang Chunjiang Liu Yanni Li Fei Guo Jianjun Qiao School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China School of Computer Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Chemical Engineering Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China Key Laboratory of Systems Bioengineering Ministry of Education(Tianjin University)Tianjin 300072China School of Computer Science and Technology College of Intelligence and ComputingTianjin UniversityTianjin 300350China Department of Engineering Science University of OxfordOxford OX13PJUK Institute of Shaoxing Tianjin UniversityShaoxing 312300China

Many diseases and health conditions are closely related to various microbes,which participate in complex interactions with diverse drugs;nonetheless,the detailed targets of such drugs remain to be *** existing studies have reported causal associations among drugs,gut microbes,or diseases,calling for a workflow to reveal their intricate *** this study,we developed a systematic workflow comprising three modules to construct a quorum sensing-based Drug-Microbe-Disease(QSDMD)database(http://***/),which includes diverse interactions for more than 8,000 drugs,163 microbes,and 42 common *** interactions between microbes and more than 8,000 drugs have been systematically studied by targeting microbial QS receptors combined with a docking-based virtual screening technique and in vitro experimental ***,we have constructed a QS-based drug-receptor interaction network,proposed a systematic framework including various drug-receptor-microbe-disease connections,and mapped a paradigmatic circular interaction network based on the QS-DMD,which can provide the underlying QS-based mechanisms for the reported causal *** QS-DMD will promote an understanding of personalized medicine and the development of potential therapies for diverse *** work contributes to a paradigm for the construction of a molecule-receptor-microbe-disease interaction network for human health that may form one of the key knowledge maps of precision medicine in the future.

关键词： quorum sensing drugs microbe-disease association microbe-host interaction gut microbiota personalized medicine

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quorum sensing systems regulate heterotrophic nitrification-aerobic denitrification by changing the activity of nitrogen-cycling enzymes

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Environmental Science and Ecotechnology 2020年第2期2卷 40-47页

作者： Ziqian Zhu Yang Yang Anran Fang Yu Lou Guojun Xie Nanqi Ren Defeng Xing State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China

Heterotrophic nitrification-aerobic denitrification(HNAD)is essential in diverse nitrogen-transforming *** HNAD is modulated by quorum sensing(QS)systems is still *** QS system in Pseudomonas aeruginosa manipulates colony ***,we described the influence of the Pseudomonas quinolone signal(PQS)and N-acyl-L-homoserine lactone(AHL)on *** HNAD of *** was inhibited by the oversecretion of ***-or PQS-deficient *** mutants had a higher ability for nitrogen *** inhibited heterotrophic nitrification mainly via controlling the activity of nitrite oxidoreductase(NXR)and the depressed aerobic denitrification by regulating the catalytic abilities of nitric oxide reductase(NOR),nitrite reductase(NIR),and nitrate reductase(NAR).The addition of citrate as the sole carbon source increased the nitrogen removal efficiency compared with other carbon ***,as the sole nitrogen source,could be used entirely with only the moderate concentration of PQS *** and PQS controlled both nitrification and denitrification,suggesting that QS plays an important role in nitrogen cycle under aerobic conditions.

关键词： Heterotrophic nitrification-aerobic denitrification quorum sensing Pseudomonas aeruginosa Nitrogen cycle Wastewater treatment

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quorum sensing:An Emerging Role for Vibrio Infection and Host Defense

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Infectious Microbes & Diseases 2024年第2期6卷 47-55页

作者： Hao-Nan Lin Xian-Hui Huang Xin-Jun Miao Wei-Lin Hu Yong-Liang Lou Dan-Li Xie The School of Laboratory Medicine&Life Sciences Wenzhou Medical UniversityWenzhouChina Key Laboratory of Laboratory Medicine Ministry of Education of ChinaWenzhouChina Wenzhou Key Laboratory of Sanitary Microbiology WenzhouChina Department of Emergency Wenzhou Central HospitalWenzhouZhejiangChina Department of Microbiology School of MedicineZhejiang UniversityHangzhouChina Zhuji Institute of Biomedical Research School of PharmacyWenzhou Medical UniversityZhujiChina

quorum sensing(QS)is a mechanism that allows bacteria to regulate various physiological and biochemical functions by secreting,sensing and responding to signaling molecules called autoinducers(AIs).In Vibrio species,QS plays a crucial role in modulating different biological *** can influence the formation of biofilms,which are communities of bacteria encased in a protective *** also controls flagella formation and motility,ensuring that Vibrio *** move efficiently in response to environmental ***ally,QS in Vibrio *** the production of different virulence factors based on cell *** enables the bacteria to adjust their virulence strategies accordingly,enhancing *** also influences the interaction between Vibrio *** their ***ing infection by Vibrio spp.,QS can affect the host immune response and colonization *** the role of QS in these interactions is crucial for unraveling the complex dynamics between Vibrio *** the *** summary,research on QS in Vibrio *** revealed its significance in regulating various biological phenotypes,controlling virulence factor production and affecting host de*** provides valuable insights into the intricate mechanisms underlying microbial behavior,host adaptation and Vibrio ***.

关键词： quorum sensing Vibrio species biological phenotype bacterial virulence host defense

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Performance and role of N-acyl-homoserine lactone(AHL)-based quorum sensing(QS) in aerobic granules

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Journal of Environmental Sciences 2014年第8期26卷 1615-1621页

作者： Yaochen Li Junping Lv Chen Zhong Wen Hao Yaqin Wang Jianrong Zhu School of Environment Beijing Normal University School of Water Resource and Environment Shijiazhuang University of Economics

The present study investigated the relationship between N-acyl-homoserine lactone（AHL）-based quorum sensing（QS） and the physico-chemical properties of aerobic *** mature granules were observed in SBR2 and SBR3 with average diameters of 0.96,and1.49 mm,respectively. The sludge densities of aerobic granules in SBR2 and SBR3 were1.0246,and 1.0201 g/mL,respectively,which were higher than that of flocculent sludge in SBR1（1.0065 g/mL）. The results showed that the activity of AHL-based QS in SBR2 and SBR3 amounted to 2.4- and 2.1-fold induction,however,that in SBR1 with flocculent sludge was1.6-fold induction. In addition,the results also showed that the activity of AHL-based QS in the three reactors rose in the feast condition,and then dropped with the consumption of substrate. However,the activity of AHL-based QS in these three reactors recovered again in prolonged starvation. Furthermore,the results showed that the enhancement of AHL-based QS favored the extracellular polymeric substance production of microorganisms in activated sludge. Thus,it could be concluded that aerobic granules showed higher AHL-based QS than flocculent sludge,which resulted from the higher sludge density of aerobic granules than flocculent sludge. AHL-based QS was related to the metabolism energy in the feast condition; however,in prolonged starvation,microorganisms would emit more AHL-like molecules to protect themselves to resist starvation. Moreover,the enhancement of AHL-based QS favored the EPS component productivity of the microorganisms in activated sludge,which contributed to maintain the aerobic granular structure.

关键词： Aerobic granules N-acyl-homoserine lactone quorum sensing Extracellular polymeric substances

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Dynamics and Mechanism of A quorum sensing Network Regulated by Small RNAs in Vibrio Harveyi

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Communications in Theoretical Physics 2011年第3期55卷 465-472页

作者： SHEN Jian-Wei Institute of Applied Mathematics Xuchang University Xuchang 464000 China Institute of System Biology Shanghai University Shanghai 200444 China

Bacterial quorum sensing （QS） has attracted much interests and it is an important process of cell communication. Recently, Bassler et al. studied the phenomena of QS regulated by small RNAs and the experimental data showed that smafl RNAs played important role in the QS of Vibrio harveyi and it can permit the fine-tuning of gene regulation and mmntenance of homeostasis. According to Michaelis-Menten kinetics and mass action law in this paper, we construct a mathematical model to investigate the mechanism induced QS by coexist of small RNA and signal molecular （AI） and show that there are periodic oscillation when the time delay and Hill coefficient exceed a critical value and the periodic oscillation produces the change of concentration and induces QS. These results are fit to the experimental results. In the meanwhile, we also get some theoretical value of Hopf Bifurcation on time deday. In addition, we also find this network is robust against noise.

关键词： quorum sensing genetic network oscillation small RNA bifurcation negative feedback loop

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P_(luxI)mutants with different promoting period and their application for quorum sensing regulated protein expression

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Food Science and Human Wellness 2023年第5期12卷 1841-1849页

作者： Zhuoning Cao Zhen Liu Guilin Zhang Xiangzhao Mao College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China

quorum sensing(QS)system can dynamically control the expression of proteins along with the cell *** promoting period of QS system has been little focused on until *** this study,a self-induced dynamic regulated expression(SIDRE)system was constructed in Escherichia *** enable the system suitable for the expression of enzymes,promoter engineering was used to obtain P_(luxI)*** test the SIDRE system,alginate lyase AL493 and esterase Est7 were used as target protein for *** enzyme activity of alginate lyase and esterase reached 96.38%and 106.71%of the control strains containing the T7 *** high-density fermentation,the activity of alginate lyase expressed by the SIDRE system with P_(luxI)(T-38C)as promoter was 4.34-fold of that expressed by the T7 ***,the P_(luxI)mutants with different promoting periods and/or different strengths show great potential in both laboratory and industrial scale for protein expression.

关键词： quorum sensing Promoter engineering Enzymes Alginate lyase Esterase High-density fermentation

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The hierarchy quorum sensing networ in Pseudomonas aeruginosa

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Protein & Cell 2015年第1期6卷 26-41页

作者： Jasmine Lee Lianhui Zhang Institute of Molecular and Cell Biology Agency for Science Technology and Research Singapore Singapore Guangdong Province Key Laborato-ry of Microbial Signals and Disease Control College of Natural Resources and Environmental Sciences South China Agricultural University Guangzhou 510642 China

Pseudomonas aeruginosa causes severe and persistent infections in immune compromised individuals and cystic fibrosis sufferers. The infection is hard to eradi- cate as P. aeruginosa has developed strong resistance to most conventional antibiotics. The problem is further compounded by the ability of the pathogen to form biofilm matrix, which provides bacterial cells a protected environment withstanding various stresses including antibiotics. quorum sensing （QS）, a cell density-based intercellular communication system, which plays a key role in regulation of the bacterial virulence and biofilm formation, could be a promising target for developing new strategies against P. aeruginosa infection. The QS network of P. aeruginosa is organized in a multi-layered hierarchy consisting of at least four interconnected signaling mechanisms. Evidence is accumulating that the QS regulatory network not only responds to bacte- rial population changes but also could react to envi- ronmental stress cues. This plasticity should be taken into consideration during exploration and development of anti-QS therapeutics.

关键词： quorum sensing IQS PQS las rhl,Pseudomonas aeruginosa virulence environmental factors

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Medicinal plant products targeting quorum sensing for combating bacterial infections

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Asian Pacific Journal of Tropical Medicine 2017年第8期10卷 795-809页

作者： Abdelhakim Bouyahya Nadia Dakka Abdeslam Et-Touys Jamal Abrini Youssef Bakri Laboratory of Human Pathologies Biology Department of BiologyFaculty of Sciencesand Genomic Center of Human PathologiesMohammed V UniversityRabatMorocco Biology and health Laboratory Department of BiologyFaculty of ScienceAbdelmalek Essaadi UniversityTetouanMorocco

Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation. This therapeutic target is well-studied worldwide, nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. Therefore, this paper aims to provide a current overview of the quorum sensing system in bacteria by revealing their implication in biofilms formation and the development of antibiotic resistance, and an update on their importance as a potential target for natural substances.

关键词： quorum sensing Biofilms Bacterial resistance Natural compounds

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Gossip in the gut: quorum sensing, a new player in the hostmicrobiota interactions

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World Journal of Gastroenterology 2021年第42期27卷 7247-7270页

作者： Garance Coquant Doriane Aguanno Sandrine Pham Nathan Grellier Sophie Thenet Véronique Carrière Jean-Pierre Grill Philippe Seksik Centre de Recherche Saint-Antoine INSERMSorbonne UniversitéParis 75012France EPHE PSL UniversityParis 75014France Department of Gastroenterology and Nutrition Saint-Antoine HospitalAPHPParis 75012France

Bacteria are known to communicate with each other and regulate their activities in social networks by secreting and sensing signaling molecules called autoinducers,a process known as quorum sensing(QS).This is a growing area of research in which we are expanding our understanding of how bacteria collectively modify their behavior but are also involved in the crosstalk between the host and gut *** is particularly relevant in the case of pathologies associated with dysbiosis or disorders of the intestinal *** review will examine the different QS systems and the evidence for their presence in the intestinal *** will also provide clues on the role of QS molecules that may exert,directly or indirectly through their bacterial gossip,an influence on intestinal epithelial barrier function,intestinal inflammation,and intestinal *** review aims to provide evidence on the role of QS molecules in gut physiology and the potential shared by this new *** understanding the impact of intestinal bacterial social networks and ultimately developing new therapeutic strategies to control intestinal disorders remains a challenge that needs to be addressed in the future.

关键词： Inflammatory bowel disease quorum sensing Gut microbiota Dysbiosis Inflammation Intestinal barrier

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