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Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity

Food Science and Human Wellness 2024年第1期13卷 225-240页

作者： Linzi Li Xueying Lei Lin Chen Ya Ma Jun Luo Xuebo Liu Xinglian Xu Guanghong Zhou Xianchao Feng College of Food Science and Engineering Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Synergetic Innovation Center of Food Safety and Nutrition Key Laboratory of Meat Processing and Quality ControlMinistry of EducationCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China

quercetin compounds have antioxidant,anti-inflammatory and anticancer pharmacological *** exposure to acrylamide(AA)can cause liver injury and endanger human ***,whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not ***,we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in *** vivo studies found that quercetin-like compounds protect against AAinduced liver injury by reducing oxidative stress levels,activating the Akt/m TOR signaling pathway to attenuate autophagy,and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated *** vitro studies found that quercetin compounds protected Hep G2 cells from AA by attenuating the activation of AA-induced autophagy,lowering reactive oxygen species(ROS)levels by exerting antioxidant effects and thus attenuating oxidative stress,increasing mitochondrial membrane potential(MMP),and improving apoptosis-related proteins,thus attenuating AA-induced ***,the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity,with quercetin showing the best protective capacity due to its strongest antioxidant *** conclusion,quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress,autophagy and apoptosis,and their protective capacity correlates with antioxidant activity.

关键词： quercetin compounds Acrylamide Protection mechanism Oxidative stress Antioxidant activity

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