检索结果-南通市图书馆

quantum dots protect against MPP＋-induced neurotoxicity in a cell model of Parkinson＇s disease through autophagy induction

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2016年第11期59卷 1486-1491页

作者： Lu Wang Xiaoming Li Yuping Han Ting Wang Yun Zhao Aldalbahi Ali Nahed Nasser El-Sayed Jiye Shi Wenfeng Wang Chunhai Fan Nan Chen Division of Physical Biology and Bioimaging Center Shanghai Synchrotron Radiation FacilityCAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China School of Life Science Sichuan UniversityChengdu 610064China Chemistry Department King Saud UniversityRiyadh 11451Saudi Arabia School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China UCB Pharma SloughSL1 3WEUK

Autophagy is a basic cellular process that decomposes damaged organelles and aberrant proteins. Dysregulation of autophagy is implicated in pathogenesis of neurodegenerative disorders, including Parkinson's disease(PD). Pharmacological compounds that stimulate autophagy can provide neuroprotection in models of PD. Nanoparticles have emerged as regulators of autophagy and have been tested in adjuvant therapy for diseases. In this present study, we explore the effects of quantum dots(QDs) that can induce autophagy in a cellular model of Parkinson's disease. Cd Te/Cd S/Zn S QDs protect differentiated rat pheochromocytoma PC12 cells from MPP+-induced cell damage, including reduced viability, apoptosis and accumulation of α-Synuclein, a characteristic protein of PD. The protective function of QDs is autophagy-dependent. In addition, we investigate the interaction between quantum dots and autophagic pathways and identify beclin1 as an essential factor for QDs-induced autophagy. Our results reveal new promise of QDs in the theranostic of neurodegenerative diseases.

关键词： quantum dots autophagy Parkinson’s disease α-Synuclein Beclin1

quantum dots Compete at the Acme of MXene Family for the Optimal Catalysis

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2022年第10期14卷 36-82页

作者： Yuhua Liu Wei Zhang Weitao Zheng Key Laboratory of Automobile Materials MOE and School of Materials Science and Engineeringand Jilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy Materialsand Electron Microscopy Centerand International Center of Future ScienceJilin UniversityChangchun 130012People’s Republic of China

It is well known that two-dimensional(2D)MXene-derived quan-tum dots(MQDs)inherit the excellent physicochemical properties of the parental MXenes,as a Chinese proverb says,“Indigo blue is extracted from the indigo plant,but is bluer than the plant it comes from.”Therefore,0D QDs harvest larger surface-to-volume ratio,outstanding optical properties,and vigorous quantum confinement ***,MQDs trigger enormous research enthusiasm as an emerging star of functional materials applied to physics,chemistry,biology,energy conversion,and *** the surface properties of small-sized MQDs include the type of surface functional groups,the functionalized surface directly determines their *** the Nobel Laureate Wolfgang Pauli says,“God made the bulk,but the surface was invented by the devil,”and it is just on the basis of the abundant surface functional groups,there is lots of space to be thereof excavated from *** are witnessing such excellence and even more promising to be ***,MQDs have been widely applied to catalysis,whereas the related reviews are rarely ***,we provide a state-of-the-art overview of MQDs in catalysis over the past five years,ranging from the origin and development of MQDs,synthetic routes of MQDs,and functionalized MQDs to advanced characterization *** explore the diversity of catalytic application and perspectives of MQDs,our review will stimulate more efforts toward the synthesis of optimal MQDs and thereof designing high-performance MQDs-based catalysts.

关键词： MXene quantum dots Catalysis Surface groups Structure

quantum dots boost large-view NIR-II imaging with high fidelity for fluorescence-guided tumor surgery

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第12期35卷 497-502页

作者： Biao Huang Tao Tang Fushou Liu Shi-Hui Chen Zhi-Ling Zhang Mingxi Zhang Ran Cui College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Owing to the high spatiotemporal resolution,the second near-infrared(NIR-II)imaging window can provide high imaging contrast with diminished tissue autofluorescence and suppressed photon scattering to pinpoint the locations for tumor *** to the unique optical properties and excellent fluorescence performance,quantum dots(QDs)are regarded as ideal nanoprobes for fluorescence-guided surgery(FGS).Moreover,QDs can be excited by a variety of light sources owing to the continuous and wide absorption ***,light-emitting diode(LED)was used as the excitation source of QDs-based nanoprobes to realize FGS of tumor with high *** the LED light could irradiate a large region with consistent light intensity,signal distortion at the edge of imaging field was *** signal intensity of the view edges under LED excitation can be improved by about 5 times compared to laser ***,more micro-vessels and smaller tumors(Vtumor<5 mm^(2))could be detected,thus providing more precise guidance for tumor resection surgery.

关键词： NIR-II imaging Fluorescence-guided surgery quantum dots Light-emitting diode Tumor imaging

quantum dots-hydrogel composites for biomedical applications

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第3期33卷 1245-1253页

作者： Wenjie Zhou Zhe Hu Jinxin Wei Hanqing Dai Yuanyuan Chen Siyu Liu Zhongtao Duan Fengxian Xie Wanlu Zhang Ruiqian Guo Institute for Electric Light Sources School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Future Lighting Academy for Engineering and TechnologyFudan UniversityShanghai 200433China Zhongshan-Fudan Joint Innovation Center Zhongshan 528437China Yiwu Research Institute of Fudan University Yiwu 322000China

quantum dots-hydrogel composites are promising new materials that have attracted extensive attention due to their incomparable biocompatibility and acceptable biodegradability, leading to enormous potential applications for various fields. This review summarizes the recent advances in quantum dots-hydrogel composites with a focus on synthesis methods, including hydrogel gelation in quantum dots(QDs) solution, embedding prepared QDs into hydrogels after gelation, forming QDs in situ within the preformed gel and cross-linking via QDs to form hydrogels. In particularly, biomedical applications as bioimaging,biosensing and drug delivery are also reviewed, followed by a discussion on the inherent challenges of design optimization, biocompatibility and bimodal applications and the prospect of the future development. These results will guide the development of quantum dots-hydrogel composites and provide critical insights to inspire researchers in future.

关键词： quantum dots Hydrogels Bioimaging Biosensing Drug delivery

quantum dots as Fluorescent Labels for Detection of Heat Shock Protein in Tumor Tissue Using Laser Scanning Confocal Microscope

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2010年第2期25卷 257-259页

作者：杨欢张杰 Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Urology Renmin hospital of Wuhan University

A new quantum dots（Qdots） nanocrystal composed of semiconductor core and zinc sulfide shell, and its feasibility as labels in immunofluorescence analysis for the imaging of tumor biomarkers by laser scanning confocal microscope（LSCM） was investigated. Qdots taged by mercaptoacetic acid were conjugated with second antibody, then imaging differences of Heat Shock Proteins 70（HSP70） in renal carcinoma tissure sections with immunofluorescence analysis method using Qdots bioconjugates and conventional organic dye FITC were observed by LSCM to assess the brightness and opticalstability of Qdots. The experimental results showed Qdots bioconjugates achieved the better results in demonstrating HSP70 with more brighter color and more clear picture than FITC labels. Moreover, the label signals of Qdots did not fade clearly after continued exposure to a 488 nm laser for 1 h. The Qdots bioconjugates have good feasibility in immunofluorescence analysis for the bioimaging by LSCM.

关键词： quantum dots immunofluorescence analysis bioimaging laser scanning confocal microscope

Photoluminescent two-dimensional SiC quantum dots for cellular imaging and transport

在线全文

学校读者我要写书评

暂无评论

Nano Research 2018年第8期11卷 4074-4081页

作者： Yu Cao Haifeng Dong Shaotao Pu Xueji Zhang Research Center for Bioengineering and Sensing Technology Beijing Key Laboratory for Bioengineering and Sensing TechnologSchool of Chemistry & Biological Engineering University of Science & Technology Beijing Beijing 100083 China

Two-dimensional （2D） ultrathin SiC has received intense attention due to its broad band gap and resistance to large mechanical deformation and external chemical corrosion. However, the synthesis and application of ultrasmall 2D SiC quantum dots （QDs） has not been explored. Herein, we synthesize a type of monolayered 2D SiC QDs with advanced photoluminescence （PL） properties via a facile hydrothermal route. Their average size and thickness can be easily adjusted by altering the reaction time. The ultrasmall 2D SiC QDs exhibit a long fluorescence lifetime of 2.59 ps due to efficient quantum confinement. The applications of SiC QDs are demonstrated through labeling A549, HeLa, and NHDF cells and delivering agents for intracellular low-abundant microRNA （miRNA） detection. This advance in preparing photoluminescent SiC QDs is of great significance for broadening their potential in biomedical and optical applications.

关键词： two-dimensional SiC quantum dots cellular imaging intraceUular microRNA(miRNA) detection

Inorganic Halide Perovskite quantum dots:A Versatile Nanomaterial Platform for Electronic Applications

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2023年第2期15卷 1-31页

作者： Chien‑Yu Huang Hanchen Li Ye Wu Chun‑Ho Lin Xinwei Guan Long Hu Jiyun Kim Xiaoming Zhu Haibo Zeng Tom Wu School of Materials Science and Engineering University of New South WalesSydney 2052Australia MIIT Key Laboratory of Advanced Display Materials and Devices Institute of Optoelectronics and NanomaterialsCollege of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094People’s Republic of China

Metal halide perovskites have generated significant attention in recent years because of their extraordinary physical properties and photovoltaic *** these,inorganic perovskite quantum dots(QDs)stand out for their prominent merits,such as quantum confinement effects,high photoluminescence quantum yield,and defect-tolerant ***,ligand engineering and an all-inorganic composition lead to a robust platform for ambient-stable QD *** review presents the state-of-the-art research progress on inorganic perovskite QDs,emphasizing their electronic *** detail,the physical properties of inorganic perovskite QDs will be introduced first,followed by a discussion of synthesis methods and growth ***,the emerging applications of inorganic perovskite QDs in electronics,including transistors and memories,will be ***,this review will provide an outlook on potential strategies for advancing inorganic perovskite QD technologies.

关键词： Inorganic perovskite quantum dots Electronics Nanocrystals quantum confinement effects

Enhanced fluorescence sensing of tetracycline with Ti_(2)C quantum dots

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第4期17卷 3180-3188页

作者： Dejia Hu ShangZuo Jiang Tianhao Xia Danyang Xiao Yan Li Yanbing Hou Jin Zhong Zhang Ying-Chih Pu School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Key Lab Luminescence&Optical Information Ministry EducationBeijing JiaoTong UniversityBeijing 100044China Department of Chemistry and Biochemistry University of CaliforniaSanta CruzCalifornia 95064USA Department of Materials Science "National University of Tainan"Tainan 700301TaiwanChina

Ti_(2)C quantum dots(QDs)with rich surface functional groups have been synthesized using a hydrothermal method,and used to detect tetracycline(Tc)based on enhanced *** interaction between the surface functional groups of Ti_(2)C QDs and Tc enhanced the fluorescence of Tc at 514 nm,which is used to detect Tc quickly and *** optimal conditions,the fluorescence intensity was linear to the concentration of Tc in the range of 50.0–30.0μM,with a detection limit of 21.6 ***,the Tc-Ti_(2)C QDs detection system was evaluated for detection of Tc in milk and artificial *** study demonstrates a new and simple strategy for Tc detection,which is important for food safety and human health.

关键词： Ti_(2)C MXene quantum dots tetracycline fluorescence enhancement detection

Overcoming side reaction effects in the colloidal synthesis of ZnSe/ZnS core/shell quantum dots with an etching strategy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第8期17卷 7020-7026页

作者： Jinhua He Chenhui Wang Mingrui Liu Muhammad Ramzan Zhiwei Long Xian-gang Wu Yu Chen Haizheng Zhong MIIT Key Laboratory for Low-Dimensional quantum Structure and Devices School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Engineering Research Center for Mixed Reality and Advanced Display Technology School of Optics and PhotonicsBeijing Institute of TechnologyBeijing 100081China

The potential use of large-size ZnSe quantum dots as blue emitters for display applications has greatly inspired the colloidal ***,we report the negative effects of side reactions of large-size ZnSe quantum *** side reactions between oleic acid and oleylamine generated amidation products and H_(2)O,which led to the hydrolysis of Zn(OA)2 to Zn(OH)2 and the subsequent formation of zinc oxide(ZnO)and zinc bis[diphenylphosphinate](Zn(DPPA)2)*** side reactions resulted in the formation of a defective surface including a Se-rich surface and oxygen-related *** negative effects can be overcome by adopting an etching strategy using potassium fluoride and myristic acid in *** overcoating a ZnS shell,blue emissive ZnSe/ZnS quantum dots with a maximum photoluminescence quantum yield of up to 91%were *** further fabricated ZnSe quantum dots-based blue light-emitting diodes with an emission peak at 456 *** device showed a turn-on voltage of 2.7 V with a maximum external quantum efficiency of 4.2%and a maximum luminance of 1223 cd·m^(−2).

关键词： quantum dots ZnSe side reactions surface etching light-emitting diodes