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qishen yiqi dripping pills for Cardiovascular Diseases: Effects and Mechanisms

Chinese Journal of Integrative Medicine 2023年第9期29卷 857-864页

作者： LU Chun-miao YANG Yu-song LU Yan-min ZHU Ya-ping ZHANG Ao LYU Shi-chao ZHANG Jun-ping Department of Cardiovascular Medicine First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin300193China Graduate School Tianjin University of Traditional Chinese MedicineTianjin300193China Institute of Acute Abdominal Diseases Nankai HospitalTianjin300100China Epidemiology College of Global Public HealthNew York UniversityNew York10003USA Department of Geriatric Medicine First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin300193China

qishen yiqi dripping pills(QSYQ) is a compound of Chinese medicine, which has been used to treat coronary heart disease and cardiac dysfunction. Its natural components include astragaloside Ⅳ, flavonoids, danshensu, protocatechualdehyde, salvianolic acid B, salvianolic acid A, ginsenosides Rg1, ginsenosides Rb1, and essential oils, etc. It exerts effects of nourishing qi and promoting blood circulation to relieve pain. In this review, the bioactive components of QSYQ and its effects for treating cardiovascular diseases and possible mechanism were summarized, providing references for further study and clinical application of QSYQ.

关键词： qishen yiqi dripping pills active ingredient cardiovascular diseases mechanisms review

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Effect of qishen yiqi dripping pills combined with trimetazidine on the treatment of chronic heart failure: A meta-analysis

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Journal of Hainan Medical University 2021年第9期27卷 47-51页

作者： Feng Xie Guang-Jing Duan Bin Wang Pei-Feng Wei Lin Chen Min Li Shaanxi University of Traditional Chinese Medicine Xianyang 712046 Shaanxi

Objective:To systematically evaluate the safety and effectiveness of qishen yiqi dripping pills combined with trimetazidine in the treatment of chronic heart failure.Methods:A total of four English and Chinese electronic databases were searched:CNKI,VIP,CBM,PUBMED.Cochrane bias risk tools were used to assess the methodological quality of qualified studies.Meta-analysis was conducted by Review Manager 5.3.A total of 9 articles were included,with a total sample size of 855 cases,443 cases in the observation group and 412 cases in the treatment group.Results:qishen yiqi dripping pills combined with trimetazidine in the treatment of chronic heart failure has a total effective rate(RR=1.22,95%CI[1.15-1.30];p<0.00001),LVEF(MD=6.03,95%CI[5.39,6.67],P<0.00001),BNP(MD=-101.87,95%CI[-109.90,-93.83],P<0.00001),E/A(MD=-4.32,95%CI[-5.70,-2.93],P<0.00001),SYP(MD=-10.32,95%CI[-13.32,-7.32],P<0.00001),LVESD(MD=-5.50,95%CI[-6.03,-4.96],P<0.00001),6-MWT(MD=110.13,95%CI[96.89,123.36],P<0.00001)Adverse reactions occurred less frequently and did not affect treatment.Conclusion:This study shows that QYDP combined with TMZ can improve various indicators of CHF patients.However,due to the small sample size and the generally low quality of research,a more rigorous and reasonably designed RCT is needed to confirm these findings.

关键词： qishen yiqi dripping pills Trimetazidine Chronic heart failure Meta-analysis

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