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qingkailing injection for the treatment of acute stroke: a systematic review and Meta-analysis

Journal of Traditional Chinese Medicine 2014年第2期34卷 131-139页

作者： JiaruiWu Xiaomeng Zhang Bing Zhang Department of ClinicalChinesePharmacy SchoolofChinese Materia MedicaBeijing University of Chinese Medicine

OBJECTIVE： To evaluate systematically the clinical efficacy and safety of qingkailing （QKL） injection in the treatment of acute stroke. METHODS： Searches for randomized controlled trials into acute stroke treated with QKL injection were performed in the China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wan fang Database, Chinese Biomedical Literature Database, PubMed and Cochrane Library, from January 1979 to March 2013. Two reviewers independently retrieved the RCTs and extracted the information. The Cochrane risk of bias method was used to assess the quality of the included studies, and a Meta-analysis was conducted with Review Manager 5.2 software. RESULTS： A total of 13 studies with 1110 participants were included. The quality of the studies was generally low. The Meta-analysis indicated that the combined use of QKL and Western Medicine was significantly superior to control group therapy in terms of the total effective rate. The relative risk （RR） in the acute cerebral hemorrhage （ACH） sub-group was 1.17 [95% confidence interval （CI）（1.08, 1.26）, P=0.0001]. In the acute cerebral infarction （ACI） sub-group, RR was 1.27 [9.5% CI （1.14, 1.42）, P〈0.0001], and in the ACH and ACI mixed sub-group, RR was 1.34 [95% CI （1.20,1.50）,P〈0.00001]. Additionally, QKL promoted the absorption of hematoma [mean difference （MD）= - 3.73, 95%0 （ - 4.48, - 2.98）, P〈0.000 01], decreased neurological damage in ACI [MD= - 5.60, 95% CI （ - 8.50, - 2.70）, P=0.0002] and ACH [MD= 4.08, 95% CI （ - 8.00, 0.16）, P=0.04], promoted the recovery of awareness [RR=1.56, 95% CI （1.09, 2.21）, P=0.01] and reduced the whole blood viscosity coefficient [MD=- 0.75, 95% CI （ - 1.47, - 0.03）, P=0.04]. There were no adverse drug reactions reported in the included studies. CONCLUSION＂ Based on this systematic review, QKL combined with conventional therapy was effective compared with control treatment. However, because the articles used in the study were not of

关键词： qingkailing injection Stroke Acutecerebrovascular disease Meta-analysis Rando-mized controlled trials Review

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Therapeutic window of qingkailing injection for focal cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2011年第21期6卷 1605-1611页

作者： Fafeng Cheng Wenting Song Xianggen Zhong Yi Lu Shaoying Guo Dong Wang Weipeng Zhao Qingguo Wang College of Basic Medicine Beijing University of Chinese Medicine Beijing 100029 China Xiyuan Hospital of China Academy of Chinese Medical Sciences Beijing 100091 China

The time window in which a drug is effective varies between drugs. The present study investigated the therapeutic window of qingkailing injection for focal cerebral ischemia/reperfusion in mice. Animals underwent middle cerebral artery occlusion and were injected with qingkailing （1.5, 3, 6 mL/kg）. Infarct volume and neurological function were assessed after 24 hours of ischemia. In addition, to establish the therapeutic time window, mice were injected with 3 mL/kg qingkailing at 0, 1, 3, 4, 6, 9 and 12 hours after occlusion. Results revealed that qingkailing injection significantly reduced infarct volume and improved neurological function in model mice after cerebral infarction for up to 9 hours, demonstrating that the therapeutic window of qingkailing injection can extend to 9 hours for cerebral ischemia/reperfusion in mice.

关键词： focal cerebral ischemia qingkailing injection time window infarct volume

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qingkailing injection(清开灵注射液)for Treatment of Children Pneumonia Induced by Respiratory Syncytial Virus:A Meta-Analysis of Rando mized Controlled Trials

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Chinese Journal of Integrative Medicine 2018年第4期24卷 288-295页

作者： HE Shuai LI Wen-shi LUO Ya-jun YE Chen-li ZHANG Zhong-yi Department of Pharmacy Zhujiang Hospital of Southern Medical University

Objective： To evaluate the efficacy and safety of qingkailing injection（清开灵注射液, QKL） for treatment of children pneumonia caused by respiratory syncytial virus（RSV）. Methods： Randomized clinical trials（RCTs） comparing QKL with ribavirin injection in the treatment of children pneumonia induced by RSV were searched in Pub Med, Science Direct, Cochrane Library, Chinese VIP database, CNKI and Wanfang databases from their inception to March 2014. Meta-analyses were performed using RevMan 5.2 software. The methodological quality of the selected RCTs was evaluated by the Modified Jadad Score. The primary outcome measures were effective rate and the secondary outcomes were relief time of fever and cough. Results： Seven RCTs with 992 cases published from 2008 to 2013 were identified. The meta-analysis results indicated that QKL was more effective in cure rate [risk ratios（RR）=1.32, 95% CI（1.17, 1.50）, P〈0.01], total effective rate [RR=1.07, 95% CI（1.02, 1.13）, P=0.009] and less fever clearance time [mean difference=–0.73, 95% CI（–1.22, –0.23）, P=0.004], compared with ribavirin injection in the treatment of RSV-induced children pneumonia. No dead case was reported in all trials. There were 3 trials mentioned adverse events, 2 reported no obvious adverse event occurred while 1 reported adverse events described as skin hypersensitivity, elevation of ALT, a mild abnormal of hepatic and renal function in both QKL and ribavirin group. Conclusions： QKL was an effective and relatively safe option for the treatment of RSV-induced children pneumonia. These therapeutic effects were promising but need to be interpreted with caution due to variations in the treatment and methodological weakness in the studies.

关键词： qingkailing injection respiratory syncytial virus ribavirin pneumonia children respiratory tract infection meta-analysis randomized controlled trials Chinese medicine

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Experimental study on anaphylaxis of qingkailing injection and its components on Beagle dogs

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Journal of Traditional Chinese Medicine 2012年第4期32卷 641-645页

作者： Zhiguo Wang Danqiao Wang Yu Sui Haifeng Cui Youhua Yu Medical Experiment Center China Academy of Chinese Medical Sciences

OBJECTIVE:To study the anaphylaxis of qingkailing injection(QI) and its ***:Experimental anaphylactoid and allergic reactions were *** in the behaviors of Beagles and serum levels of histamine,immunoglobulin(Ig)E,IgG,IgM,eosinophil cationic protein(ECP),and interleukin(IL)-4,as well as blood pressure,after injecting QI and its components on the forelimb veins of Beagles were ***:According to comprehensive determination of abnormal behavior scores and changes in serum levels of histamine,IgE,IgG,IgM,ECP,and IL-4,as well as in blood pressure,radix isatidis and hyodeoxycholic acid caused anaphylactoid reactions,and honeysuckle,radix isatidis,hydrolysate,cholic acid and Gardenia jasminoides caused allergic *** anaphylaxis of QI involved anaphylactoid and allergic ***:QI and its components need to be refined further to improve the safety,efficacy,and quality of its use in clinical settings.

关键词： Anaphylaxis qingkailing injection Composition Behavior, animal Immunoglobulinisotypes Eosinophil cationic protein Interleukin-4

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Effect of qingkailing injection on rat embryonic neuronal apoptosis and mitochondrial membrane potential

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Neural Regeneration Research 2006年第6期1卷 513-517页

作者： He Pang Lingqun Zhu Shuoren Wang Fuling Niu Wei Cui Peripheral Vascular Canter Dongzhimen Hospital Beijing University of Chinese Medicine Beijing 100700. China the Key Laboratory of Chinese Internal Medicine of Ministry of Education Beijing Key Laboratory Dongzhimen Hospital Beijing University of Chinese Medicine Beijing 100700 China

BACKGROUND： The decrease of mitochondrial membrane potential （MMP） is an irreversible marker of neuronal apoptosis during ischemia/reperfusion （t/R） injury of brain tissue. qingkailing injection is proved to have protective effect on neuronal ischemic injury. Whether inhibiting the decrease of MMP can inhibit apoptosis when I/R injury of brain tissue occurs is unclear. OBJECTIVE： To observe the effect of qingkailing injection on rat embryonic hippocampal neuronal apoptosis, MMP and mitochondnal activity after hypoxia/hypoglycemia and reoxygenation, and make a comparison of therapeutic effect on I/R injury between qingkailing injection and nimodipine. DESIGN： Observation and controlled trial SETTING ： Peripheral Vascular Center, Dongzhimen Hospital, Beijing University of Chinese Medicine; the Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Key Laboratory, Dongzhimen Hospital, Beijing University of Chinese Medicine. MATERIALS： Eight Wistar rats at embryonic 18 days, provided by Breeding Farm of Experimental Animals, Chinese Academy of Medical Sciences （Permission No. SCXK-11-00-0006） were employed in this trial. qingkailing injection （Pharmaceutical Factory of Beijing University of Chinese Medicine, Batch No. 213710A, 10 mL each, baicalin 50 g and total nitrogen 25 mg included） and nimodipine （ICN company, USA） were also used. METHODS ： This experiment was carded out in the Key Laboratory of Chinese Intemal Medicine of Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine and Beijing Key Laboratory from January 2003 to December 2005. （1）The pregnant rats were anesthetized and fetal rats were isolated for culturing fetal rat hippocampal neurons. The neurons cultured for 10 days were used for experiment. The neurons were divided into 5 groups： model group, control group, nimodipine group, qingkailing high-dose group and qingkailing low-dose group. Hypoxia/hypoglycemia and reoxygenation models served

关键词： membrane potential neuronal apoptosis Chinese Medicine qingkailing injection volume fraction hippocampal neurons protective effect Experimental Animals therapeutic effect reperfusion injury Medical Sciences measurement data total nitrogen flow cytometry cell culture Wistar rats MTT assay fetal rat

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Network pharmacology assessment of qingkailing injection(清开灵注射液)treatment of cholestatic hepatitis

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Journal of Traditional Chinese Medicine 2021年第1期41卷 167-180页

作者： LIAN Yajun WANG Qingguo MU Jie LIU Haixia XU Tian FAN Shuning TANG Feifei FENG Tianyi XU Wenxiu JIN Na CHENG Fafeng WANG Xueqian The Basic Research of Classic Recipe Application Innovation Research Group College of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijing 100029China

OBJECTIVE:To investigate the targets and mechanisms of action of qingkailing injection(清开灵注射液,QKL)in the treatment of cholestatic ***:A network pharmacology method was implemented using drug and disease databases to target QKL and cholestasis hepatitis,*** functional protein association network STRING database was used to construct a protein-protein interaction network using R language and the Bioconductor *** *** and cluster Profiler packages were used for gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis,which explored biological functions and pathways of potential *** were then visualized using Cytoscape 3.6.0 ***:We screened 121 compounds in QKL and identified 112 targets for the treatment of cholestatic *** played a role in the treatment of cholestatic hepatitis through 305 biology process terms,15 cellular component and 29 molecular function *** mechanism of QKL action was mainly related to tumor necrosis factor,mitogen-activated protein kinase,and PI3 K-Akt signaling ***:The treatment of cholestatic hepatitis by QKL involved multiple targets,biological functions,and signaling pathways that are closely associated with the disease.

关键词： Cholestatic hepatitis protein interaction maps pharmacology qingkailing injection

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Modeling a murine model of IgE-mediated qingkailing injection anaphylaxis

Modeling a murine model of IgE-mediated Qingkailing injectio...

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共铸医药学术新文明——2012年广东省药师周大会

作者： Guoping Liao,Wenshi Li,Shuai He,Zhongyi Zhang~* (Dept.of Pharmacy,Zhujiang Hospital,Southern Medical University,Guangzhou 51 0282,PR China)

qingkailing injection(QKLI) is a classic compound Traditional Chinese Medical injection(TCMI).It can cause anaphylatic shock and death in *** a murine model of qingkailing injection anaphylaxis appears to be *** this study,for the first time,we used several strategies to prepare cBSA and QKLI-cBSA *** nBSA, cBSA and QKLI-cBSA conjugate were separated by cationic exchange method and also identified by UV-Vis and FT-IR ***/c mice were then treated with subcutaneous injection of QKLI-cBSA plus *** were analyzed for total IgE and histamine levels by ELISAs,*** reactions were evaluated by analyzing lung pathologic ***-cBSA group mice were significantly and successfully sensitized. QKLI-cBSA conjugate significantly increased total IgE and Histamine in Balb/c mice serum. Moreover,histological examination of QKLI-cBSA conjugate treated mice showed acute injury with pulmonary alveoli and injury of trachea,as well as neutrophilic cell *** a word,we successfully established a murine model of IgE-mediated qingkailing injection *** model should provide a useful tool for detecting allergens in QKLI and for exploring new allergens-detecting approaches of other TCMIs.

关键词： qingkailing injection murine IgE-mediated anaphylaxis QKLI-cBSA conjugate.

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qingkailing injection(清开灵注射液)

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Chinese Journal of Integrative Medicine 1999年第4期5卷 314-314页

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Application of near-infrared spectroscopy for the rapid analysis of Lonicerae Japonicae Flos solution extracted by water

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Journal of Innovative Optical Health Sciences 2014年第4期7卷 42-50页

作者： Xue Xiao Jinfang Ma Fahuan Ge Xiangdong Zhang Huihua Yang Qionghin Liang Yiming Wang Guoan Luo Nansha Research Institute Sun Yat-Sen.University Guang zhou 511458 P.R.China Department of Chemistry Tsinghua University Beijing 100084P.R.China

A rapid quantitative analytical method for three components of Lonicerae Japornicae Flos solution(Lonicera Japonica Thumb.)extracted by water was developed using near-infrared(NIR)spectroscopy and the partial least-squares(PLS)*** NIR spectra of 81 samples collected from a production line were *** concentrations of secologanic acid,chlorogenicacid and galuteolin were detemmined by using high-performance liquid chromatography-diodearray detection as the reference *** pretreatment methods for the NIR spectra wereusedi during PLS *** most appropriate latent variable number of the PLS factor wasselected based on the standard error of cross-validation(SECV).The performance of the finalPLS models was evaluated according to SECV,standard error of predliction(SEP)and deter-mination coeficient(R^(2)).The compounds secologanic acid,chlorogenic acid and galuteolin hadSEP values of 0.030,0.061 and 1.668μg/mL,respectively and R^(2) values over *** workshows that NIR spectroscopy is a rapid and convenient method for the analysis of LoniceraeJaponicae Flos solution extracted by *** proposed method can help in the application ofprocs analytical technology in the pha maceutical industry,particularly in tra ditional Chinesemedicine injections.

关键词： Lonicerae Japonicae Flos qingkailing injection near-infrared partial least-squares rapid analysis

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