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Preventive Effects of qingfei yihuo capsules(清肺抑火胶囊)on Air Pollution Associated Exacerbation of Chronic Obstructive Pulmonary Disease:A Single-blind,Randomized,Controlled Trial

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Chinese Journal of Integrative Medicine 2020年第11期26卷 806-811页

作者： Hu Wei-ping Wu Xiao-dan Li Zhuo-zhe Zhang Jing Department of Pulmonary Medicine Zhongshan Hospital of Fudan UniversityShanghai200032China

Objective To investigate the efficacy of qingfei yihuo capsules(清肺抑火胶囊,QYCs)in preventing the air pollution associated exacerbation of chronic obstructive pulmonary disease(COPD).Methods This was a prospective,parallel,single-blind,randomized,placebo-controlled *** patients with stable Group D COPD were randomly allocated to receive either oral QYCs(intervention group)or placebos(control group,30 cases per group)for 15 days in the presumed high-incidence air pollution season and followed-up for 1 *** groups were given individualized Western medicine therapy according to the Global Initiative for Chronic Obstructive Lung Disease criteria as *** and separate numbers of acute exacerbation(AE)associated with striking air pollution was the primary *** outcomes included total numbers of deteriorating respiratory symptoms and separate numbers associated with striking air pollution,as well as scores of COPD Assessment Test(CAT)and modified Medical Research Council Scale(mMRC).Results All the 60 patients completed the *** was no statistical significance in total numbers of AE between the two groups(P>0.05).Compared with the control group,a significant reduction in air-pollution associated numbers of deteriorated respiratory symptoms was observed in the intervention group(1.9–1.2 vs.3.6–2.4,P0.05).Only 2 patients in the intervention group reported diarrhea and recovered after drug *** For patients with Group D COPD,oral QYCs in high-incidence season of air pollution can effectively mitigate respiratory symptoms associated with air pollution,although there was no evidence that it had a significant reductive effect on AEs.(Registered at Chinese Clinical Trial Registry,registration ***-IOR-17013827).

关键词： chronic obstructive pulmonary disease qingfei yihuo capsules air pollution acute exacerbation randomized controlled trial Chinese medicine

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