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Long-term effects of qingfei paidu decoction(清肺排毒汤)in patients with coronavirus disease 2019 acute pneumonia after treatment:a protocol for systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2023年第6期43卷 1068-1071页

作者： FAN Rong HE Haoyu TANG Tao CUI Hanjin Institute of Integrative Medicine Xiangya HospitalCentral South UniversityChangsha 410008China Department of Psychology School of Educational ScienceHunan First Normal UniversityKey Laboratory of Hunan Province for Children's Psychological Development and Brain Cognitive ScienceChangsha 410205China

This study aims to provide evidence regarding whether Qingufei paidu decoction(清肺排毒汤,QFPD)treatment in the acute phase shows long-term benefits for coronavirus disease 2019-associated *** 10 databases will be *** reference list of related trials and gray literature will be searched as *** screening,data extraction,and risk of bias evaluation will be performed by two reviewers(CUI Hanjin and FAN Rong).Data analysis will be conducted by using STATA(version 14).Statistical heterogeneity will be explored by a standardχ2 test with a significance level of P<*** plots,Egger’s&Begg’s test,and Trim and Fill analysis will be used for publication bias *** results of the present Meta-analysis and systematic review will be disseminated via peer-review journal *** approval is not required,as this Meta-analysis will not contain any individual patient *** systematic review has been registered on PROSPERO(registration number:CRD42021246937)on 15 April 2021.

关键词： COVID-19 qingfei paidu decoction protocol systematic review Meta-analysis

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“qingfei paidu decoction”—A Possible Choice of Phytotherapy for Severe Acute Respiratory Infection Caused by Coronavirus Disease-19

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American Journal of Plant Sciences 2020年第7期11卷 1111-1136页

作者： Hualiang Chen Dandan Song Tianlai Gao Jingjing Yang Yutao Ma Qian Deng Department of Pharmacy Shaoxing Seventh People’s Hospital Shaoxing China

This work is aimed to study the therapeutics and pharmacology of the treatment of severe acute respiratory infection caused by coronavirus disease-19 (COVID-19) with traditional Chinese medicine (TCM) “qingfei paidu decoction”. We analyze the “Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia” (Version I to Version VII) made by China, “Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected—Interim guidance” made by World Health Organization (WHO), “Therapeutic Guidelines: Respiratory” published by Australia, and the origin of classical prescription of Qingfei Paidu Decoction: “Shanghan Lun (Treatise on Febrile Diseases)” and “Jinkui Yaolue (Synopsis of Golden Chamber)”. We search the dictionary of traditional Chinese medicine (Version II) manually. We search literatures from 2001 to 2020 on Wiley online library. We conduct a comparative study on the therapeutic options and indications among Qingfei Paidu Decoction, COVID-19 and chronic obstructive pulmonary disease (COPD). And we carry out pharmacological inquiry of Qingfei Paidu Decoction. The therapeutic options and indications of Qingfei Paidu Decoction in China, COVID-19 and COPD are considered to be basically consistent. Qingfei Paidu Decoction has a definite therapeutic effect on the symptoms, basic diseases and complications for COVID-19 and COPD. Qingfei Paidu Decoction is a possible choice of phytotherapy for severe acute respiratory infection caused by COVID-19.

关键词： qingfei paidu decoction COVID-19 COPD Pharmacology Therapeutics

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Discussion on the composing principle of "qingfei paidu decoction"in the treatment of anti-COVID-19 from the theory of syndrome-differentiation of the six meridians in Treatise on Febrile Diseases

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Journal of Hainan Medical University 2020年第19期26卷 1-6页

作者： Han Wang Dun-Fang Wang Hong-Xin Song Xu-Ran Ma Di-Xin Zou Jin-Xue Miao Yan-Li Wang Wei-Peng Yang College of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchunJilin130117China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing100700China

The coronavirus disease 2019(COVID-19)was a newly discovered infectious respiratory disease and characterized by wide prevalence,high incidence rate and fast progress and dangerous,which belonged to the category of"cold-wet plague"in *** onset of COVID-19 was caused by pestilence,which mingled with seasonal cold-dampness and invaded the human body when external defensive qi was weak and then leaded to the accumulation of Yang *** from exogenous pathogenic factors transmitted from the external to the internal or followed the transmission law of Wei,Qi,Ying and Xue,the nature of pestilence belonged to the category of pathogenic fire,spreading as soon as possible,from the external to the internal and from the upper and lower part of triple energizer,even to every *** the very beginning,the pestilence attacked from the Taiyang meridian into the Yangming meridian quickly,or straight into the three Yang meridian,which was called"triple-yang combination of diseases".Manifestations of fever,aversion to cold and pain of body were conformed to the exterior syndrome of Taiyang,as well as manifestations of fullness and discomfort in chest,vomiting and spitting and diarrhea were conformed to the syndrome of half-interior-half-exterior;And symptoms manifested as high fever,faint,and abdominal fullness and constipation were conformed to the syndrome of Yangming;But sometimes,there was cold-dampness surrounding the exterior at the beginning along with intense interior pathogenic *** at the beginning,the exterior factors invaded into three Yin meridians quickly while have not been eliminated,which may lead to the syndrome of inner blocking causing collapse or Jue *** most typical syndrome of COVID-19 was triple-yang combination of diseases,which was often seen in mild,moderate and part of severe ***"qingfei paidu decoction"was prescribed especially for this kind of *** accurate efficacy has been proved by that mild cases converting to

关键词： Coronavirus disease 2019(COVID-19) Syndrome-differentiation of the six meridians qingfei paidu decoction Composing principle Pestilence

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New insights for infection mechanism and potential targets of COVID-19:Three Chinese patent medicines and three Chinese medicine formulas as promising therapeutic approaches

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Chinese Herbal Medicines 2023年第2期15卷 157-168页

作者： Kexin Jia Yijie Li Tiegang Liu Xiaohong Gu Xiaojiaoyang Li School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China Institute of Chinese Epidemic Disease Beijing University of Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with high pathogenicity and infectiousness has become a sudden and lethal pandemic ***,there is no accepted specific drug for COVID-19 ***,it is extremely urgent to clarify the pathogenic mechanism and develop effective therapies for patients with *** to several reliable reports from China,traditional Chinese medicine(TCM),especially for three Chinese patent medicines and three Chinese medicine formulas,has been demonstrated to effectively alleviate the symptoms of COVID-19 either used alone or in combination with Western *** this review,we systematically summarized and analyzed the pathogenesis of COVID-19,the detailed clinical practice,active ingredients investigation,network pharmacology prediction and underlying mechanism verification of three Chinese patent medicines and three Chinese medicine formulas in the COVID-19 ***,we summarized some promising and high-frequency drugs of these prescriptions and discussed their regulatory mechanism,which provides guidance for the development of new drugs against ***,by addressing critical challenges,for example,unclear targets and complicated active ingredients of these medicines and formulas,we believe that TCM will represent promising and efficient strategies for curing COVID-19 and related pandemics.

关键词： COVID-19 Huashi Baidu Formula Jinhua Qinggan Granules Lianhua Qingwen Capsule qingfei paidu decoction SARS-CoV-2 traditional Chinese medicine Xuanfei Baidu Formula Xuebijing Injection

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Study on the Inheritance,Innovation and Development of Scutellaria baicalensis Georgi in the Treatment of COVID-19

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Medicinal Plant 2020年第4期11卷 3-9页

作者： Yuanpeng SUN Yusi LIU Zheng CHENG Zhe WU Yanling SUN College of Basic Medicine Hubei University of Science and Technology Xianning 437100 China

The discovery of highly effective medicine"qingfei paidu decoction"for COVID-19 is a new era gift of traditional Chinese medicine to the *** traditional Chinese medicine Scutellaria baicalensis Georgi,as a medicinal plant in the family of Labiatae,is the dominant variety of genuine medicinal material in North *** is the leading traditional Chinese medicine in the advantageous area of agricultural products with Chinese characteristics in Shangdang of Changzhi City,and it is one of the 21 herbal medicines in the new national prescription"qingfei paidu decoction"for the rapid and effective treatment of *** paper introduces *** Georgi and its traditional Chinese medicine GAP base,ecologically suitable planting county and medicinal value in poor areas,and studies the intellectual property resources related to *** Georgi,such as traditional knowledge,biological genetic resources,patents,new plant varieties,geographical indications,and *** paper mainly discusses the inheritance essence,innovation and high-quality development strategy of *** Georgi under the rural revitalization strategy and traditional Chinese medicine development strategy from the aspects of intellectual property rights,important agricultural cultural heritage,advantageous areas of characteristic agricultural products and so on.

关键词： Scutellaria baicalensis Georgi qingfei paidu decoction COVID-19 Chinese herbal medicine High-quality development Rural revitalization strategy Development strategy of traditional Chinese medicine

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