检索结果-南通市图书馆

qiming granule in treating type 2 diabetic kidney disease patients:study protocol for a randomized controlled trial

Traditional Medicine Research 2021年第1期6卷 7-15页

作者： Jian Huo Jun-Guo Duan Xue-Jing Lu Fu-Wen Zhang Wen-Yuan Jian Jia-Qing Sui Jia-Ling Ai Li-Sha Liu College of Ophthalmology Chengdu University of Traditional Chinese MedicineChengdu 610075China Chengdu Women’s and Children’s Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China Ineye Hospital Chengdu 610084China

Background:Diabetic kidney disease(DKD)is a chronic renal microvascular complication associated with abnormal glucose *** to traditional Chinese medicine(TCM)theory,Qi and Yin deficiency with blood stasis(the name of TCM symptoms,its main clinical features are fatigue,dry mouth,red or pale tongue,weak pulse,etc.)is the primary TCM syndrome of DKD,and qiming granule(QMG)is suitable for the treatment of Qi and Yin deficiency with blood stasis *** view of this,we designed a randomized controlled trial to assess whether QMG is efficacious and safe in treating DKD ***:This protocol is for a randomized,double-blind,placebo-controlled,parallel group,six-centre clinical trial.A total of 180 participants will be randomized into the QMG group or placebo group,with a 1:1 *** study will last for 50 weeks,including a 2-week run-in period,24 weeks of intervention,and 24 weeks of *** experimental intervention will be QMG,and the control intervention will be a *** primary outcome will be the 24h urinary albumin excretion ratio and the change in the albumin-to-creatinine *** secondary outcome will be evaluation of renal function,fundus changes,management of blood lipids,TCM symptom improvement and safety *** events will be recorded during the ***:This study is a randomized controlled trial to test the effectiveness and safety of QMG for DKD *** findings of this study will help to provide evidence-based recommendations in treating DKD *** registration:Chinese Clinical Trial Registry,*** 23 December 2012.

关键词： Diabetic kidney disease qiming granule Traditional Chinese medicine Randomized controlled trial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of qiming granule(芪明颗粒) on Retinal Blood Circulation of Diabetic Retinopathy:A Multicenter Clinical Trial

引用

Chinese Journal of Integrative Medicine 2009年第5期15卷 384-388页

作者：罗向霞段俊国廖品正吴烈余扬桂邱波王育良李毓敏阴正勤刘晓玲姚克 Department of Ophthalmology Chengdu University of Traditional Chinese Medicine Department of Ophthalmology Gansu Provincial Hospital of Traditional Chinese Medicine Guang' anmen Hospital China Academy of Chinese Medical Sciences The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangdong Hospital of Traditional Chinese Medicine Jiangsu Hospital of Traditional Chinese Medicine The First Affiliated Hospital of College of Medicine Zhejiang University Southwest Hospital Hospital of Optometry and Ophthalmology Wenzhou Medical CollegeZhejiang Province The Second Affiliated Hospital of College of Medicine Zhejiang University

Objective： To objectively assess the effect of qiming granule （芪明颗粒） in the treatment of diabetic retinopathy （DR） by fluorescence fundus angiography （FFA）. Methods： In a multi-center, randomized, parallel controlled clinical trial, patients with DR were randomly assigned to the control group （calcium dobesilate capsule） and the test group （qiming granule）. Changes in the retinal blood circulation time were recorded by FFA after 3 months of medication. Results： Significant reduction was observed in the retinal arterio-venous circulation time （AVCT） in both groups （P〈0.01）, the value was 7.635 ± 3.149 s before treatment and 5.165 ±3.382 s after treatment in the treated group, and 7.737±3.413 s and 5.313±3.472 s in the control group respectively. qiming granule also reduced the arm-to-retinal circulation time （ARCT, P〈0.05）. The value was 17.867± 3.872 s before treatment and 15.643 ± 4.648 s after treatment in the treated group, and 17.217 ± 3.833 s and 16.312± 3.613 s in the control group （P〉0.05） respectively. The ARCT in the tested group was reduced, with a statistically significant difference post-medication （P〈0.01）. Conclusion： As a Chinese medicine complex prescription, qiming granule may alleviate retinal hypoxia and ischemia by increasing retinal blood flow and improving the blood circulation.

关键词： diabetic retinopathy fluorescence fundus angiography retinal blood circulation time qiming granule

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research of the clinical efficacy of qiming granule in treatment of diabetic nephropathy by meta-analysis

引用

TMR Modern Herbal Medicine 2021年第3期4卷 37-48页

作者： Ning Liu Tao He Chuanxin Liu Jianmei Huang Beijing University of Chinese Medicine School of Chinese Materia MedicaBeijing 100029China

Objective:To systematically evaluate the clinical efficacy of qiming granule combined with conventional therapy in improving diabetic ***:The Chinese and English databases such as Wanfang,VIP,CNKI,PubMed,Cochrane library and Web of Science database were *** searching time was from the database was established to March 1,*** papers were screened strictly according to the inclusion and exclusion *** inclusion risk assessment tool provided by the Cochrane Collaboration was used to evaluate the included literature,the data was analyzed using STATA 12.0 ***:Twelve papers were included,involving 1369 *** results of meta-analysis showed that qiming granule combined with conventional treatment had statistical significance in improving the clinical total effective rate[RR=1.24,95%CI(1.12,1.36)],urinary albumin excretion rate[SMD=-2.68,95%CI(-3.86,-1.50)],creatinine[SMD=-1.46,95%CI(-1.84,-1.08)],urea nitrogen[SMD=-2.61,95%CI(-3.85,-1.36)],fasting blood glucose[SMD=-1.17,95%CI(-2.03,-0.31)]and cystatin C[SMD=-3.26,95%CI(-4.65,-1.87)]of patients with diabetic ***:The combination of conventional therapy and qiming granule can improve the clinical effect for diabetic ***,due to the low level of overall literature evidence,high risk and some kind of publication bias,it still needs more high-quality and large-scale clinical studies for further verification.

关键词： qiming granule Diabetic Nephropathy Meta-Analysis Clinical Effects Randomized Controlled Trials

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stationary Treatment Compared with Individualized Chinese Medicine for Type 2 Diabetes Patients with Microvascular Complications:Study Protocol for a Randomized Controlled Trial

引用

Chinese Journal of Integrative Medicine 2018年第10期24卷 728-733页

作者： HUO Jian LIU Li-sha JIAN Wen-yuan ZENG Jie-ping DUAN Jun-guo LU Xue-jing YIN Shuo College of Ophthalmology Chengdu University of Traditional Chinese Medicine Good Clinical Practice Center the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine

Background： Microvascular complications in type 2 diabetes （T2DM）, including diabatic retinopathy （DR）, diabetic kidney disease （DKD）, diabetic peripheral neuropathy （DPN） are the leading causes of visual loss, end-stage renal disease or amputation, while the current therapies are still unsatisfactory. Chinese medicine （CM） has been widely used for treating diabetic mettitus. However, most of the previous studies focused on the single complication. The role of CM treatment in T2DM patients with 2 or multiple microvascular complications is not clear. Objective： To appraise the curative effect of CM in T2DM patients with 2 or multiple microvascular complications, and to compare the effects of stationary treatment and individualized treatment in T2DM patients with microvascular complications. Methods： This trial will be an 8-center, randomized, controlled study with 8 parallel groups. A total of 432 patients will be randomized to 8 groups： DR study group （32 cases） and a corresponding control group （32 cases）, DR＋DKD study group （64 cases） and a corresponding control group （64 cases）, DR＋DPN study group （64 cases） and a corresponding control group （64 cases）, DR＋DKD＋DPN study group （56 cases） and a corresponding control group （56 cases）. The control group will receive stationary treatment, and the study group will receive individualized treatment based on CM syndrome differentiation in addition to stationary treatment. The study duration will be 50 weeks, comprising a 2-week run-in period, 24 weeks of intervention, and 24 weeks of follow-up. The outcomes will assess efficacy of treatment, improvement in CM symptoms, safety assessments, adherence to the treatment, and adverse events. Conclusion： This study will provide evidence of evidence-based medicine for CM treatment in two or multiple microvascular complications caused by T2DM. （Registration No. ChiCTR-IPR-15007072）

关键词： Chinese medicine diabetic microvascular complications randomized controlled trial qiming granule

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：