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Inhibition of qi and Qo sites of mitochondrial complexⅢinduced opposite effects on HVA calcium channels via activation of different protein kinase C isoforms in cortical neurons

Inhibition of Qi and Qo sites of mitochondrial complexⅢindu...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Pei-Ying WU,Bin LAI,Ping ZHENG~* State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai Medical College,Shanghai 200032, China

＜正＞Objective Inhibition of qi and Qo sites of mitochondrial complexⅢunder hypoxia and ischemia has received attention,but its downstream targets remain largely *** work showed altered function of sodium channels after the inhibition of complexⅢ.HVA calcium channels were well recognized to be an important factor in ischemia-induced cell *** explore whether the inhibition of mitochondrial complexⅢhas any effect on the function of HVA calcium channels and the related downstream pathways will shed light on our understanding about the complicated events after hypoxia/*** Electrophysiological recording of HVA calcium currents was carried out on slice preparations from 14-day-old rats using whole cell recording *** of qi and Qo sites of mitochondrial complexⅢwas mimicked by application of specific inhibitors antimycin A and myxothiazol *** drugs were applied through the bath ***（1） Antimycin A decreased the peak amplitude of HVA calcium current while myxothiazol increased it.（2） Antimycin A induced the effect via the activation ofβ1 isoform of protein kinase C while myxothiazol increased the amplitude of calcium currents through the activation ofδisoform.（3） The effect of antimycin A on HVA calcium channels could be abolished by the application of antioxidants PHEN and MPG while the superoxide scavenger MnTB Aβand SOD could cancel the effect of *** Inhibition of mitochondrial complex HI at different sites exerted opposite effects on HVA calcium channels.

关键词： cortical neuron whole cell patch-clamp mitochondria complexⅢ qi site Qo site antimycin A myxothiazol HVA calcium channels Protein Kinase C isoforms reactive oxygen species superoxide

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