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Systemic Immune Inflammatory Index Is Associated with pustular Psoriasis: A Single Center Retrospective Study

Journal of Cosmetics, Dermatological Sciences and Applications 2022年第4期12卷 174-186页

作者： Salah Hassan Ibrahim Mengqi Guan Shanshan Li Department of Dermatology and Venerology First Hospital of Jilin University Changchun China

Introduction: Psoriasis is a chronic multi-systemic inflammatory skin disease that presents with erythema, thickness, and scaling of the skin. Genetic and environmental factors are associated with its etiology. Recently systemic immune inflammatory index, has been proposed as a biomarker for prognosis and severity prediction. Although it has been studied in psoriasis in general, no study exists for its association with the individual types of psoriasis. This study thus aimed to determine its association with clinical characteristics of psoriasis subtypes. Materials and Methods: Data were retrospectively retrieved from the hospital electronic medical database from January 2020 to August 2022. Only patients with CBC results were included. Clinical data retrieved were: Patients’ age, gender, type of psoriasis diagnosed, body mass index, duration of the disease, family history of psoriasis, history of smoking, diabetes, and hypertension records. Laboratory data retrieved were: Complete blood count (CBC), C-reactive protein, Immunoglobulin E (IgE), Total cholesterol, Triglycerides and Low-density lipoprotein cholesterol. Data were analyzed in SPSS and GraphPad prism. Results: The study enrolled 85 patients with psoriasis;56.47% males, and 43.53% females. 7.6% had psoriasis for less than 10 years, while 42.4% had the disease for more than 10 years. Psoriasis vulgaris was the most common diagnosis, 41.2%, followed by p. pustular, 30.6% and then p. erythroderma 28.2%. Mean age ± SD of the p. vulgaris, p. pustular and p. erythroderma patients were 47.3 ± 15.3;45.3 ± 14.6, and 57.1 ± 11.7 respectively. SII was significantly higher in p. pustular than the rest, (p Conclusion: In summary, systemic immune inflammatory index (SII) was significantly higher in psoriasis pustular than other subtypes of psoriasis, and had an association with hypertension in psoriasis pustular patients. These findings suggest a possible association between SII and psoriasis pustular that should be inv

关键词： Systemic Immune Inflammatory Index Psoriasis pustular

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Staphylococcal bullous impetigo in a neonate

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World Journal of Clinical Cases 2016年第7期4卷 191-194页

作者： Shalini Dewan Duggal Tanisha Bharara Pragnya Paramita Jena Avinash Kumar Abha Sharma Renu Gur Sanjay Chaudhary Department of Microbiology Dr Baba Saheb Ambedkar Hospital Department of Pediatrics Dr Baba Saheb Ambedkar Hospital

An otherwise healthy, full-term neonate presented at day 15 of life to the pediatric emergency with generalized papulo-pustular rash for 2 d. This was finally diagnosed as bullous impetigo caused by Staphylococcus aureus(S. aureus). The skin lesions decreased significantly after starting antibiotic therapy and drainage of blister fluid. There was no recurrence of the lesions on followup. This case of generalized pustular eruption due to S. aureus in a neonate is reported, as it poses a diagnostic dilemma and can have serious consequences if left untreated.

关键词： pustular lesions Staphylococcus aureus Bullous impetigo

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Genome Annotation and Comparative Genomics of ORF Virus

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Advances in Microbiology 2014年第15期4卷 1117-1131页

作者： A. K. M. Firoj Mahmud K. M. Zillur Rahman Shuvra Kanti Dey Tahsina Islam Ali Azam Talukder Molecular Biology Department Umea University Umea Sweden Deptartment of Microbiology Jahangirnagar University Savar Bangladesh

ORF virus (ORFV), the etiological agent of contagious pustular dermatitis in small ruminants, belongs to members of the genus Parapoxvirus of the Poxviridae. The genome of the ORFV is dsDNA of 139,962 bp which has about 89% coding region, 63% GC content and codes 130 proteins. There are four unique genes within the genome revealed by homology search of them two posses’ strong regulatory region and transmembrane helices. One of the ORF-039 contains signal peptide indicating the possibilities to be secretory protein coding gene. Comparative genomic analysis reveals significant differences in Bovine Papular Stomatitis Virus (BPSV) strain BV-AR02 and ORFV strain OV-SA00, and these may account for differences in host range. Interspecies sequence variability is observed in all functional classes of genes but is the highest in putative virulence/host range genes. Notably, ORFV contains genes which are homologous of Vaccinia virus. Phylogenetic analysis reveals that although divergent, ORFV virus is distinct from other known mammalian cowpox virus. An improved understanding of Parapoxvirus (PPV) biology will permit the engineering of novel vaccine viruses and expression vectors with enhanced efficacy and greater versatility. The novel vaccine will have a significant role in the economy of a country through the control of disease in an economically important and small ruminant caused by ORFV.

关键词： ORF Virus Contagious pustular Dermatitis Comparative Genomics GLIMMER ACT Uniue Genes Novel Vaccine

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