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A novel herbal combination ameliorates ovarian dysfunction and regulates altered biochemical parameters in rats with letrozole-induced polycystic ovary syndrome

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Asian pacific Journal of Reproduction 2023年第1期12卷 23-34页

作者： Sunita Shailajan Sasikumar Menon Swati Singh Yugandhara Patil Herbal Research Lab(Department of Botany) Ramnarain Ruia Autonomous CollegeMatungaMumbai-400019India Therapeutic Drug Monitoring Laboratory Sion(East)Mumbai-400022India

Objective:To investigate the potential activity of novel herbal combination and novel herbal formulation(syrup)in female Sprague Dawley rats with letrozole-induced polycystic ovary syndrome(PCOS).Methods:Forty-two rats were randomly divided into seven groups with six rats in each *** 1 received 0.5%carboxy methylcellulose orally for 37 days and served as the normal control *** 2 was orally administered with letrozole of 1 mg/kg for 21 days and served as the PCOS induction group without *** 3 to 7 were administered with letrozole of 1 mg/kg for 21 days orally to induce PCOS,and then respectively received clomiphene citrate at 1 mg/kg,100 and 200 mg/kg of novel herbal combination,200 mg/kg of novel herbal formulation(syrup),and 400 mg/kg of marketed formulation of pushyanuga churna,once daily for 15 *** of the novel herbal combination and its syrup formulation were evaluated on the hormonal profile,the levels of antioxidants,the lipid profile and on the ovarian morphology,using letrozole-induced PCOS model in ***:Letrozole caused alterations in hormonal levels and lipid levels similar to PCOS and ovarian histology showed presence of ovarian cysts confirming the induction of PCOS in *** treatment with the novel herbal combination and its syrup formulation in PCOS-induced rats,the altered hormonal and lipid profiles showed significant recovery to normal *** histology confirmed the restoration of folliculogenesis in the PCOS-induced *** treatment with the syrup formulation of novel herbal combination was found to be more effective than novel herbal combination and showed better recovery in various parameters *** results of the study,however,suggested that treatment with novel herbal combination and its syrup formulation provided minimal protection against oxidative stress caused due to the induction of ***:The integrated approach for management of PCOS is to counterbalance the limita

关键词： Polycystic ovarian syndrome Polyherbal combination Letrozole pushyanuga churna Clomiphene citrate Histopathology Biochemical Herbal

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