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Strontium doped electrospinning fiber membrane with antibacterial and osteogenic properties prepared by pulse electrochemical method

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Engineered Regeneration 2022年第4期3卷 339-351页

作者： Yonggang Liu Bolin Zhang Feifei Liu Yani Qiu Wenbo Mu Liang Chen Chuang Ma Tingjun Ye Yingbo Wang College of Chemical Engineering Xinjiang Normal University102 Xinyi RoadUrumqi 830054PR China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai 200025PR China Department of Orthopedics Center The First Affiliated Hospital of Xinjiang Medical University393 Xinyi RoadUrumqi 830054PR China Department of Pharmaceutical Research Shanghai Medicilon Inc.No.585 Chuanda RoadPudong New AreaShanghai 201299PR China Chemistry and Chemical Engineering Changji UniversityChangji 831100PR China

The osteogenic differentiation and new bone formation are commonly delayed by bacterial infection of orthopedic implants,which is urgent to be resolved quickly in the *** current paper prepared a strontium-doped elec-trospinning fiber membrane with antibacterial and osteogenic properties by pulse electrochemical ***-lactic acid/hydroxyapatite(PLLA/HA)composite fiber substrate was fabricated by electrospinning technology,and strontium doped SrHA/Cu/Polypyrrole(PPy)composite coating was constructed with pulse electrodeposi-tion method on its *** strontium doping technique,degradation of Sr^(2+)and Cu^(2+),cellular compatibility,and the antibacterial activity of the fiber membrane were *** results revealed that the deposition of phosphorus and calcium on composite fiber was the highest,indicating good biological *** release of Sr^(2+)and Cu^(2+)was stable and gradual due to the modulation of *** composite fiber presented excellent antibacterial performance and the antibacterial rate was close to 100%against Staphylococcus aureus and Es-cherichia ***,it is conducive to the adhesion,spread,and proliferation of vascular endothelial cells and osteoblasts,namely outstanding osteogenesis and angiogenesis *** conclusion,the multifunctional PLLA/HA@SrHA/Cu/PPy composite fiber membrane with good antibacterial and osteogenic activity by electro-spinning technology and pulsed electrochemical deposition method provides an effective strategy for the poor bone healing of infected bone defects.

关键词： Electrospinning pulse electrodeposition method Bone induction Antibacterial property

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