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Effects of Xinfeng capsule on pulmonary function based on treg-mediated notch pathway in a rat model of adjuvant arthritis

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Journal of Traditional Chinese Medicine 2012年第3期32卷 430-436页

作者： Lei Wan Jian Liu Chuanbing Huang Yuan Wang Xi Shen Wandong Zhang Guizheng Wang Haixia Fan Yao Ge Ruilian Chen Yunxiang Cao Ruikai Zong Li Lei Hubei University of Chinese Medicine Wuhan Hu-bei 430065 China Department of Rheumatism Immunity First Affiliated Hospital Anhui College of Traditional ChineseMedicine Hefei Anhui 230031 China Department of Rheumatism Immunity First Affiliated Hospital Anhui Col-lege of Traditional Chinese Medicine Hefei Anhui 230031China

OBJECTIVE:To observe the impact of xinfeng xapsule(XFC) on pulmonary function in a rat model of adjuvant arthritis(AA) and to investigate the mechanism of ***:Forty rats were randomly divided into four groups of ten:normal control(NC);model control(MC);tripterygium glycosides tablet(TPT);and xinfeng capsule(XFC).Except for the NC group,AA was induced in all rats by intracutaneous injection of 0.1 mL Freund's complete adjuvant in the right paw on the 19th *** and MC groups were given(0.9%) physiological *** TPT and XFC groups were given TPT(10 mg/kg) and XFC(1.2 g/kg),*** days after administration,changes in paw edema(E),the arthritis index(AI),pulmonary function,levels of regulatory T-cells(Treg),ultrastructure of lung tissue,and expression of Notch receptors and ligands in lung tissue were ***:In the MC group,E and the AI were increased and pulmonary function significantly decreased;the structure of alveolar type-II cells was damaged;ratios of Treg in peripheral blood were reduced;and expression of Notch receptors such as Notch3 and Notch4 and ligands such as Delta1 in lung tissue were significantly increased whereas expression of Notch1,Jagged1 and Jagged2 were significantly *** intervention with XFC,E and the AI were decreased;pulmonary function was enhanced;the structure of alveolar type-II cells was improved;and expression of Treg,Notch1,Jagged1,Jagged2 was elevated,whereas that of Notch3,Notch4 and Delta1 was ***:XFC can not only inhibit E and the AI and improve joint symptoms,it can also improve pulmonary function and reduce inflammation in lung *** actions could be carried out through increases in the expression of Treg,Notch receptors(Notch1) and ligands(Jagged1,Jagged2),and reductions in the expression of Notch3,Notch4 and *** phenomena would reduce the deposition of immune complexes and the inflammatory response in lung tissue,thereby improving joint symptoms an

关键词： Arthritis,Experimental pulmonary function Receptors Notch T-Lymphocytes Regulatory Xinfeng capsule

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Effect of continuous nursing combined with respiratory exercise nursing on pulmonary function of postoperative patients with lung cancer

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World Journal of Clinical Cases 2023年第6期11卷 1330-1340页

作者： Qiong-Xiang Qiu Wen-Juan Li Xi-Miao Ma Xue-Hua Feng Department of Thoracic Surgery Haikou People’s HospitalHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikou 570208Hainan ProvinceChina

BACKGROUND Lung cancer is a malignant tumor with high morbidity and mortality among *** is currently one of the primary methods of treating lung *** it can slow down the progression of the disease by removing the lesion,this invasive surgery inevitably damages the integrity of the patient’s ***,the patient’s pulmonary function may have a low compensatory capacity after surgery,causing various respiratory diseases such as atelectasis,respiratory function decline,and even serious cardiovascular *** of these have great negative impacts on the surgical effect and the prognosis of *** the continuous exploration and development of nursing,continuous nursing and respiratory exercise nursing have been gradually applied in the nursing of patients after lung cancer surgery,and have achieved good nursing *** To investigate the effect of continuous nursing combined with respiratory exercise nursing on the pulmonary function of postoperative patients with lung *** A total of 80 patients with lung cancer who underwent surgery in our hospital from January 2021 to December 2021 were selected as the study *** subjects were randomly divided into the control group(n=40 cases)and the experimental group(n=40 cases).Patients with lung cancer in the control group were given conventional nursing after surgery,while the experimental group was given continuous nursing combined with respiratory exercise nursing based on conventional *** recovery of pulmonary function and respiratory symptoms was observed before and after 3 mo of intervention in both *** pulmonary function parameters,blood gas analysis,MD Anderson Symptom Inventory-lung cancer module(MDASI-LC)scores,incidence of pulmonary complications,and Morisky compliance scores were compared between the two groups before and after 3 mo of *** There was no significant difference in pulmonary function and blood gas analysis betwee

关键词： Postoperative lung cancer Continuous nursing Respiratory exercise nursing pulmonary function

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Commentary on impact of pulmonary function on robotic pulmonary resection

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第3期4卷 93-94页

作者： Anthony Le Matheus Carelli Allen Guo Christopher Cao Department of Cardiothoracic Surgery Royal Prince Alfred HospitalSydney UniversitySydneyAustralia The Baird Institute for Applied Heart and Lung Surgical Research SydneyAustralia Chris O'Brien Lifehouse SydneyAustralia

Buitrago and colleagues should be commended on an excellent case report on the effective use of the robotic platform for a successful minimally invasive left lower lobectomy for a patient with biopsy proven squamous cell carcinoma.1 Despite a predicted postoperative forced expiratory volume in one second(ppoFEV1)of 23%and a preoperative diffusing capacity for carbon monoxide(DLCO)of 21%,the patient underwent a lobectomy without any intraoperative complications or evidence of disease at 15 months *** node sampling was performed from 5 *** postoperative length of staywas not clearly *** authors made several interesting points about the impact of pulmonary function on postoperative outcomes,the oncological efficacy of lobectomy versus sublobar resections,and merits of roboticassisted thoracoscopic surgery(RATS)versus thoracotomy and conventional video-assisted thoracoscopic surgery(VATS).We would like to discuss these points in further detail based on the available evidence in the current literature.

关键词： pulmonary function Lung cancer Robot-assisted thoracoscopic surgery Lobectomy

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pulmonary function by Spirometry in Children with Perinatal HIV Infection

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World Journal of AIDS 2020年第4期10卷 215-222页

作者： Nancy J. Gálvez Julio W. Juárez Pediatric Infectology Hospital Roosevelt Guatemala Guatemala Integrated Assistance Unit for HIV and Chronic Infections Hospital Roosevelt “Dr. Carlos Rodolfo Mejía Villatoro” Guatemala Guatemala

Background: In an age of antiretroviral therapy, the life expectancy of children perinatally infected with Human Immunodeficiency Virus (HIV) has significantly increased. At the same time, however, pulmonary pathologies secondary to opportunistic infections have decreased thanks to increased diagnostics and access to antiretroviral therapy (ART). Despite this, in these children an immune dysregulation is maintained due to chronic infection. There is evidence that these patients have increased probability of presenting with abnormalities in pulmonary function, mainly with chronic obstructive clinical pictures (25% - 40% of perinatally infected adolescents display some anomaly in the spirometry), which predisposes them to increased risk of chronic pulmonary disease. Since lung development occurs mainly during infancy, patients perinatally infected with HIV may suffer consequences. This can be secondary to opportunistic infections, chronic inflammation due to the virus, and immunologic effects of ART, mainly in non-industrialized countries, where late diagnosis is frequent. Methodology: An analytical, observational, cross-sectional study was conducted at Roosevelt Hospital Pediatric infectious disease clinic, from January to December 2019. A sample of 76 patients was obtained, out of a population of 362 patients. A total of 62 subjects, who met the criterion of reproducibility in the spirometry, were analyzed. Results were analyzed with percentages and the association of variables using the chi-squared test (χ2). Results: A decrease in pulmonary function was found in 34% of patients, mild obstructive pattern (16%) predominating. Significant association between basal viral load greater than 100,000 cp/ml and a decrease in Forced expiratory flow 25 - 75 (FEF 25-75) (p 0.046) and in relationship between forced expiratory volume and forced vital capacity (FEV1/ FVC p = 0.024) was obser

关键词： pulmonary function Perinatal HIV Infection Spirometry

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Xinfeng Capsule(新风胶囊)for the Treatment of Rheumatoid Arthritis Patients with Decreased pulmonary function—A Randomized Controlled Clinical Trial

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Chinese Journal of Integrative Medicine 2016年第3期22卷 168-176页

作者：万磊刘健黄传兵汪元谌曦张皖东王桂珍范海霞葛瑶陈瑞莲曹云祥纵瑞凯刘天阳 Department of Rheumatology The First Affiliated Hospital of Anhui University of Chinese Medicine

Objective： To determine the effectiveness and safety of Xinfeng Capsules （新风胶囊, XFC） for the treatment of rheumatoid arthritis （RA） patients with decreased pulmonary function. Methods： This was a randomized controlled clinical trial of 80 RA patients. Participants were assigned to the tdal group （40 cases） and the control group （40 cases） by block randomization. The trial group was treated with XFC, three pills each time three times daily for 2 months. The control group was treated with tripterygium glycoside （TPT）, two pills each time three times daily for 2 months. Both groups were followed up after 2 months. The clinical effects, changes in joint and pulmonary function, and quality of life before and after treatment were observed; safety indices were also evaluated. Results： Pain, swelling, tenderness, and duration of morning stiffness of joints were obviously decreased after treatment in both the trial and the control groups compared with baseline （P〈0.01）. Compared with before treatment, hand grip strength increased significantly after treatment in the trial group （P=0.0000）; pulmonary function parameters such as forced expiratory volume in the first second of expiration/forced vital capacity （FEV1/FVC）, 50% of the expiratory flow of forced vital capacity （FEFso）, carbon monoxide diffusing capacity （DLco） were increased （P〈0.01 or P〈0.05）; measures of quality of life such as role-physical, body pain, vitality and mental health were also improved after treatment in the trial group （all P〈0.05）. Joint swelling in the trial group decreased compared with the control group （P=0.0043）, while hand grip strength was increased after treatment （P=0.0000）. The increase in FEFs0, DLco, and the dimensions of quality of life such as vitality and mental health were all significantly greater in the trial group than the control group （P〈0.05 or P〈0.01）. Conclusions： XFC not only relieved joint pain in RA patients, but also significantly improved the ventilation and diffusion fu

关键词： rheumatoid arthritis pulmonary function quality of life Xinfeng Capsule clinical trial

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Mid-term effects of lung volume reduction surgery on pulmonary function in patients with chronic obstructive pulmonary disease

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Chinese Medical Journal 2007年第8期120卷 658-662页

作者： LIU Jin-ming YANG Wen-lan JIANG Ge-ning DING Jia-an ZHENG Wei LIU Wen-zeng WANG Ying-min GAO Bei-lan JIANG Ping WU Wen LI Xia Jonson Bjorn Department of Respiratory Medicine Pulmonary Function Test Laboratory and Department of Thoracic Surgery Shanghai Pneumology Hospital Tongji University Shanghai 200433 China Department of Clinical Physiology Lund University Sweden

Background Now lung volume reduction surgery （LVRS） has become one of the most effective methods for the management of some cases of severe chronic obstructive pulmonary disease （COPD）. We evaluated the mid-term effects of LVRS on pulmonary function in patients with severe COPD. Methods Ten male patients with severe COPD aged 38-70 years underwent LVRS and their pulmonary function was assessed before, 3 months and 3 years after surgery. The spirometric and gas exchange parameters included residual volume, total lung capacity, inspiratory capacity, forced vital capacity, forced expiratory volume in one second, diffusion capacity for CO, and arterial blood gas. A 6-minute walk distance （6MWD） test was performed.Results As to preoperative assessment, most spirometric parameters and 6MWD were significantly improved after 3 months and slightly 3 years after LVRS. Gas exchange parameters were significantly improved 3 months after surgery, but returned to the preoperative levels after 3 years. Conclusions LVRS may significantly improve pulmonary function in patients with severe COPD indicating for LVRS. Mid-term pulmonary function 3 years after surgery can be decreased to the level at 3 months after surgery. Three years after LVRS, lung volume and pulmonary ventilation function can be significantly improved, but the improvement in gas exchange function was not significant.

关键词： lung volume reduction surgery chronic obstructive pulmonary disease treatment outcome pulmonary function

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Statin therapy on pulmonary function in patients with COPD: a meta-analysis of randomized controlled trials

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Journal of Chinese Pharmaceutical Sciences 2018年第4期27卷 281-288页

作者： Yi Zhou Jun Wang Long Zhang Department of Emergency Medicine Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School Nanjing 210008 China

In the current meta-analysis, we aimed to investigate the therapeutic effects of statins on pulmonary function in patients with chronic obstructive pulmonary disease （COPD）. MEDLINE, EMBASE and Cochrane Central Register of clinical trials were systematically searched until January 2017 for RCTs of statins. Only trials with COPD patients were included. The I2 statistic was used to measure heterogeneity between trials and calculated mean differences for pulmonary function parameters with fixed-effect meta-analysis. Eight eligible studies with 534 participants were identified. Statin therapy had no remarkable influence on FEV1 （SMD -0.01, 95% CI -0.204 to 0.184, 12 = 0.0%, P = 0.922, n = 409）, FEV1/FVC （SMD 0.163, 95% CI -0.044 to 0.369, 12 = 0.0%, P = 0.123, n = 364）, 6MWD, heart rate or CRP. However, exercise time on treadmill was remarkably improved by statin therapy （SMD 1.271, 95% CI 0.930 to 1.612, 12 = 0.0%, P = 0.000, n = 160）. Subgroup analysis showed significant, ameliorative effect ofpravastatin on FEV1/FVC （SMD 0.362, 95% CI 0.049 to 0.674, 12 = 0.0%, P = 0.023）. The results of this meta-analysis showed non-significant effect of statins on pulmonary function in COPD patients. Based on the studies reviewed, it is not recommended to prescribe statins for COPD patients without CVD risk factors due to lack of clearly defined benefit.

关键词： Statins pulmonary function COPD Meta-analysis

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Randomized Control Trial on the Efficacy of Dual Bronchodilator of Glycopyrronium/Indacaterol for Lung Cancer Surgery: Improvement of Postoperative pulmonary function in Both Patients with Chronic Obstructive pulmonary Disease and Normal pulmonary function

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Surgical Science 2020年第6期11卷 133-165页

作者： Takanori Ayabe Masaki Tomita Ryo Maeda Koichiro Ochiai Tomoka Hamahiro Kunihide Nakamura Division of Thoracic and Breast Surgery Department of Surgery Faculty of Medicine University of Miyazaki Miyazaki Japan

Background: A dual bronchodilator, long-acting anticholine drugs (glycopyrronium, LAMA) and the long running β-2 stimulant (indacaterol, LABA), are effective for the treatment of chronic obstructive pulmonary disease (COPD). To evaluate the effectiveness of the perioperative intervention of LAMA/LABA, a randomized prospective trial was performed for the lung cancer patients receiving a lobectomy with normal pulmonary function and COPD. Methods: Based on the results of the preoperative pulmonary function test, 25 patients were diagnosed with COPD [% forced expiratory volume in 1 second (%FEV1) 1), who were randomized into two groups, the LAMA/LABA (n = 19) and the Control group (n = 18). The LAMA/LABA and the COPD groups daily received inhaled LAMA (50 μg) and LABA (110 μg) for 1 week before surgery and for least 4 weeks after surgery. The Control group had no treatment of the dual bronchodilator. The actual values were measured during the perioperative pulmonary function at three points of the preoperative baseline, the postoperative 1 week and the postoperative 4 weeks;these changes and changed ratios were then calculated. The patient-reported outcomes of the quality of life (PRO-QOL) were evaluated by the Cancer Dyspnea Scale (CDS), the COPD assessment test, and the St. George’s Respiratory Questionnaire. Results: Regarding the value of FEV1 at the baseline, that in the LAMA/LABA group was 79.2% ± 6.4% and that in the Control group was 80.9% ± 6.4%, but that in the COPD groups was 57.9% ± 8.7%;there was a significant difference between the COPD and the Control group (p 1 value in the Control group was 1.3 ± 0.5 L and that in the LAMA/LABA group was 1.7 ± 0.5 L. On the other hand, that in the COPD group was 1.7 ± 0.5 L

关键词： Glycopyrronium/Indacaterol pulmonary function Lobectomy Lung Cancer Randomized Control Trial

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Effects of TCM Nursing Based on Syndrome Differentiation on pulmonary function and Quality of Life in Patients with Acute Exacerbation of COPD

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Medicinal Plant 2023年第4期14卷 77-79页

作者： Xiaolan FANG Ran MO Yuanhui JIANG Yaonan DU Nanchong Chinese Medicine Hospital Nanchong 637000China

[Objectives] To investigate the effects of TCM nursing based on syndrome differentiation on pulmonary function and quality of life in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). [Methods] A total of 92 patients with AECOPD who came to Nanchong Chinese Medicine Hospital from March 2022 to February 2023 were selected for the study, and the intervention group (TCM nursing based on syndrome differentiation, 46 cases) and the conventional group (basic nursing, 46 cases) were selected for the study, and the pulmonary function and quality of life of the two groups were compared. [Results] Before nursing, there was no significant difference in levels of forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and percentage of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) between the intervention group and conventional group ( P >0.05). After 3 months of nursing, the levels of FVC, FEV1 and FEV1/FVC in the intervention group were higher than those in the conventional group ( P functions between the two groups ( P >0.05). At three months of nursing, the scores of health, emotion, and social functions in the intervention group were higher than those in the conventional group ( P pulmonary function and quality of life of patients, and has significant clinical implementation value.

关键词： Chronic obstructive pulmonary disease(COPD) TCM nursing based on syndrome differentiation pulmonary function Quality of life

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Effect of warming needle moxibustion on pulmonary function of elderly patients with stable chronic obstructive pulmonary disease

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World Journal of Acupuncture-Moxibustion 2014年第3期24卷 21-24页

作者：谢金辉俞建辉余姚市小曹娥镇卫生院中医科宁波市第二医院针灸科

Objective To observe the therapeutic effects of warming needle moxibustion on pulmonary function of elderly patients with stable chronic obstructive pulmonary disease. Method Eighty elderly patients with stable chronic obstructive pulmonary disease were divided randomly into an acupuncture group and a drug group, with forty cases in each group. The patients in the acupuncture group were treated with warming needle moxibustion on specific acupoints. Main acupoints include Zusanli （足三里 ST 36）, Feishu （肺俞 BL 13） and Dingchuan （定喘 EX-B 1）. Matching acupoints include Gaohuang （膏肓 BL 43）, Xinshu （心俞 BL 15）, Dazhui （大椎 GV 14） and Fangmen （风门 BE 12）. The acupoints were punctured with even reinforcing and reducing method. Meanwhile, two moxa stick of warming needle moxibustion were applied separately at the acupoints at back and ST 36. The needles were retained for approximately 0.5 h each time. The treatment was given every other day, 3 times a week and the course of treatment was 8 weeks. Patients in the drug group were treated by seretide inhalation （50 μg salmeterol and 250 μg fluticasone propionate）, twice a day for 8 weeks. The improvement in pulmonary function and the symptom of chills and fever were compared between the two groups. Results After treatment, pulmonary function indices [forced expiratory volume in one second （FEV1）, forced expiratory volume in one second to forced vital capacity （FEVl/FVC）, forced expiratory volume in one second to predicted value ratio （FEV1%） and peak expiratory flow （PEF）] of the patients in both groups were improved significantly compared with that before treatment （P〈0.05）. There was no statistically significant difference between the two groups （all P〉0.05）. Improvement in comprehensive scores of the symptom of chill and fever in the acupuncture group was significantly superior to that in the drug group after 4 and 8 weeks of the treatment, respectively （P〈0.05）. Conclusion Warming needle moxibustion was obviously effective on the

关键词： stable chronic obstructive pulmonary disease in elderly patients acupuncture therapy pulmonary function warming needle moxibust-ion

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