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Anti-Candida and anti-Cryptococcus evaluation of 15 non-alkaloidal compounds from pterogyne nitens

Asian Pacific Journal of Tropical Biomedicine 2016年第10期6卷 841-845页

作者： Caroline Sprengel Lima Carlos Roberto Polaquini Mariana Bastos dos Santos Fernanda Patricia Gullo Fernanda Sangalli Leite Liliane Scorzoni Vanderlan da Silva Bolzani Maria Jose Soares Mendes-Giannini Ana Marisa Fusco-Almeida Andréia Alves Rezende Luis Octavio Regasini Laboratory of Green and Medicinal Chemistry Department of Chemistry and Environmental Sciences Institute of Biosciences Letters and Exact Sciences Sao Paulo State University (UNESP) Department of Clinical Analysis School of Pharmaceutical Sciences Sao Paulo State University (UNESP) Department of Organic Chemistry Institute of Chemistry Sao Paulo State University (UNESP) Department of Biology and Animal Sciences Faculty of Engineering Sao Paulo State University (UNESP)

Objective: To evaluate anti-Candida and anti-Cryptococcus activities of 15 nonalkaloidal compounds from pterogyne nitens Tulasne(Leguminosae), a South American medicinal ***: Compounds were submitted to antifungal assays, using microdilution method described by Clinical and Laboratory Standards Institute document, with minor modifications. Five species of Candida and two species of Cryptococcus, including clinical isolates were screened. Antifungal activity was expressed by minimum inhibitory concentration(MIC). Amphotericin B and fluconazole were used as standard antifungal ***: Among tested compounds, six substances presented fungal growth inhibition(MIC nitensoside B(3), two glycosylated flavone derivatives, were active against Cryptococcus neoformans ATCC 90012(MIC = 7.80 mg/m L).Conclusions: Flavone derivatives from pterogyne nitens can serve as prototypes for the design and development of innovative anti-Candida and anti-Cryptococcus hits.

关键词： Candida Cryptococcus Antifungal pterogyne nitens Flavonoid Opportunistic fungi

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