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Metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

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World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： Mohammad M Khan Zaw Ali Khan Mohsin Ali Khan Laboratory of Translational Neurology and Molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s Lucknow Medical College and Hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term use has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： psychotropic medications Metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

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Metabolic syndrome:a psychiatric outlook

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Psychosomatic Medicine Research 2023年第1期5卷 1-5页

作者： Javed Ather Siddiqui Shazia Farheen Qureshi Ibrahim Mohammed Alghamdi Hani Matrok Alotaibi Department of Psychiatry Seth Gordhandas Sunderdas Medical College and the King Edward Memorial HospitalMumbai 400012India Department of Psychiatry College of Physicians and Surgeons of BombayMumbai 400012India Department of Psychiatry Mental Health HospitalTaif 21944Saudi Arabia

A metabolic syndrome is a cluster of clinical signs that are risk factors for the development of type 2 diabetes mellitus,and cardiovascular *** cluster includes obesity,elevated blood sugar,high blood pressure,and high *** antipsychotics that are associated with a group of signs and symptoms have resulted in an increased focus on this *** review included accessible literature,such as review articles and original research *** provides useful guidelines for psychiatrists and gives them psycho-education so that they can identify and monitor patients who may have the syndrome and properly manage it.

关键词： metabolic syndrome psychotropic medications obesity

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