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Pharmacokinetic study about compatibility of Eucommia ulmoides and psoralea corylifolia

Chinese Herbal Medicines 2023年第2期15卷 263-270页

作者： Yuxing Huang Erwei liu Xuhua Huang Jia Hao Siyuan Hu Xiumei Gao Tianjin University of Traditional Chinese Medicine Tianjin 301617China Tianjin Key laboratory of Phytochemistry and Pharmaceutical Analysis Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Key laboratory of Chinese Medicine Pharmocology Tianjin University of Traditional Chinese MedicineTianjin 301617China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300193China

Objective:The compatibility of Eucommia ulmoides(Eu)and psoralea corylifolia(Pc)on the pharmacokinetic(PK)properties in the rat was explored in this ***:Eu extract,Pc extract and the combined extracts(crude drug ratio was 2:1)was administered by gavage,*** PK experiments were *** first one,the blood samples were collected via the occuli chorioideae vein to get the PK properties of the *** second one,the blood samples were simultaneously collected via the internal jugular vein or portal vein at different time points and the concentrations of target ingredients were detected by lC/MS/MS to clear the location where the interaction of Eu and Pc took place in ***:Eight of 11 ingredients in Eu and Pc extract were determined in rat *** exposure levels of geniposidic acid(GPA),aucubin(AU),geniposide(GP),pinoresinol diglucoside(PDG),psoralen glycosides(PlG)and isopsoralen glycosides(IPlG)were decreased 1/5–2/3 after administration of combined *** to the combined administration,the exposure of GPA and AU in plasma of single Eu administration collected via the portal vein were decreased 1/3–2/3,and the values of AUC0-24h and AUC0-∞ of GP collected from the portal vein or internal jugular vein were double *** other components’parameters were not significantly ***:In summary,the Pc and Eu combined administration could affect the exposure of the main components of Eu extract in rats due to the changed intestinal *** research on the compatibility of Pc and Eu was helpful to guide the clinical administration of Eu and Pc simultaneously.

关键词： double intubation drug interaction Eucommia ulmoides Oliver lC/MS/MS pharmacokinetic properties psoralea corylifolia l

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