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Proteome-wide screening for the analysis of protein targeting of Chlamydia pneumoniae in endoplasmic reticulum of host cells and their possible implication in lung cancer development

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BIOCELL 2022年第1期46卷 87-95页

作者： YANYAN LI SHAHANAVAJ KHAN ANIS AHMAD CHAUDHARY HASSAN AHMED RUDAYNI ABDUL MALIK ASHWAG SHAMI Department of Oncology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou450007China Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia Department of Biosciences Shri Ram Group of College(SRGC)Muzaffarnagar251001India Department of Health Sciences Novel Global Community Educational FoundationSydneyAustralia Department of Biology College of ScienceImam Mohammad Ibn Saud Islamic University(IMSUI)Riyadh11623Saudi Arabia Department of Biology College of SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11617Saudi Arabia

Available reports have confirmed a link between bacterial infection and the progression of different types of cancers,including colon,lungs,and prostate *** we report the Chlamydia pneumonia proteins targeting in endoplasmic reticulum(ER)using in-silico approaches and their possible role in lung cancer *** predicted 48 proteins that target human ER,which may be associated with protein folding and protein-protein interactions during *** results showed *** proteins targeting human ER and their implications in lung cancer *** targeted proteins may be involved in competitive interactions between host and bacterial proteins,which may change the usual pathway functions and trigger the development of lung ***,*** unfolded protein accumulation in the human ER possibly induces ER stress,consequently activating the unfolded protein response(UPR),and providing a favorable microenvironment for cancer *** current study showed the *** protein targeting in ER of host cell and their implication in lung cancer *** results may help researchers better manage lung cancer and establish a molecular mechanism for *** lung cancer association.

关键词： Bacterial infection C.pneumoniae proteomes ER Lung cancer

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