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protein-based biomaterials for combating viral infections:Current status and future prospects for development

Biosafety and Health 2022年第2期4卷 87-94页

作者： Yongyue Han Juanli Pan Yanhong Ma Dongfang Zhou Wei Xu Department of Pulmonary and Critical Care Medicine Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Research Center of Medical and Pharmaceutical Bioengineering Ministry of Health.Daan Gene Co.LtdGuangzhou 510665China

The outbreak of viral infections are serious threat to human life and ***,there remains to be a lack of effective treatments and prophylactic measures against some viral ***,there are numerous challenges in developing vaccines and antiviral drugs(e.g.,antibodies and protein inhibitors),such as low immunogenicity of vaccines,difficulties in storing vaccines,instability and easy degradation of protein drugs,and lack of drug ***-based biomaterials can interact with antiviral drugs or vaccines to achieve synergistic or enhanced effects,making them a promising antiviral tool with many *** fibroin has the potential to stabilize liquid vaccines at room ***-like polypeptide modification can improve the stability and yield of virus-neutralizing *** in combination withβ-casein or serum albumin(SA)has good prospects in treating human immunodeficiency virus(HIV)***,the greatest value of SA as a protein-based antiviral material lies in its ability to target the liver and *** the future,combination with SA(direct conjugation or encapsulation with drugs)may be a better treatment strategy for viral hepatitis and HIV infections because it leads to fewer adverse *** addition,selfassembling protein nanoparticles(SApNPs)are found to improve vaccine *** combination of multiple viral immunogens and multiple SApNPs produces different promising vaccine candidates,thus highlighting the value of *** review aimed to discuss the current status and future prospects for the development of protein-based biomaterials to combat viral infections.

关键词： Viral infections protein-based biomaterials Antiviral drugs Vaccines

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