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Star fruit extract and C-glycosylated flavonoid components have potential to prevent air pollutant-induced skin inflammation and premature aging

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Natural Products and Bioprospecting 2022年第1期12卷 158-167页

作者： Ping Wu Hiroyasu Iwahashi Hai-Hui Xie Ying Wang Yan-Yang Zhou Akinori Kiso Yoshihito Kawashima Xiao-Yi Wei Key Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Digital Botanical Garden and Public Science South China Botanical GardenChinese Academy of SciencesXingke Road 723Tianhe DistrictGuangzhou 510650People’s Republic of China Research Center Maruzen Pharmaceuticals Co.Ltd.1089-8 SagataShin-ichi-ChoFukuyama-CityHiroshima 729-3102Japan

Air pollution adversely affects skin,leading to skin inflammation and premature skin *** derived antioxidant compounds have been considered to be promising in discovery of effective agents for the protection of skin from the damage by air *** previous studies demonstrated that Averrhoa carambola fruit(known as star fruit)is rich in flavonoid C-glycosides with unique structures and potent antioxidant ***,the star fruit extract(SFE)and main flavonoid C-glycoside components,carambolasides I,J,and P(1-3),carambolaflavone B(4),and isovitexin 2″-O-α-l-rhamnoside(5),were investigated for the activity against air pollutant stress in human *** a result,SFE and compounds 1-5 exhibited significant inhibitory activity against protein carbonylation in oxidative-stressed stratum corneum with the best activity being shown by compound *** and compounds 2-5 were also active against engine exhaust-induced protein carbonylation in stratum *** further evaluated,SFE and com-pound 3 significantly inhibited gene expression of the key inflammation mediators IL-1αand COX-2 in PM-stressed *** results indicated that SFE and the flavonoid C-glycosides are potentially effective against air pollutant-induced skin inflammation and premature aging.

关键词： Star fruit Carambolaside P Air pollution protein carbonylation Skin inflammation Premature skin aging

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Mechanism of Novel Natural Products Maintaining Skin

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China Detergent & Cosmetics 2021年第4期6卷 56-60页

作者： Chen Min Pang Ying Pan Sha Hangzhou CN Formulator Technology Co. Ltd.China

The inducement of skin carbonylation was briefly introduced,then the mechanism of protein carbonylation from skin was discussed and adverse reactions to human skin were ***,according to the mechanism of protein carbonylation and the degradation mode,the proposed solutions were as follows:diglucosyl gallic acid,Hibiscus sabdariffa flower extract;Prunus cerasus flower extract can reduce the protein carbonylation level of skin by reducing t ROS and Phaeodactylum tricornutum extract can improve the activity of 20s enzyme and accelerating the hydrolysis level of carbonyl protein,to achieve the perfect repair of skin.

关键词： protein carbonylation skin maintian diglucosyl gallic acid hibiscus sabdariffa flower extract

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