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Livedoid Vasculopathy Secondary to protein c deficiency:A case Successfully Treated With Rivaroxaban

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International Journal of Dermatology and Venereology 2023年第3期6卷 175-177页

作者： Nattanicha chaisrimaneepan Tanongkiet Tienthavorn Institute of Dermatology Ministry of Public HealthBangkok 10400Thailand Division of Dermatosurgery Institute of DermatologyDepartment of Medical ServicesMinistry of Public HealthBangkok 10400Thailand

Introduction:Livedoid vasculopathy is a chronic noninflammatory skin disease secondary to hypercoagulable *** therapeutic guideline has yet been established for livedoid *** herein report a case of livedoid vasculopathy secondary to protein c deficiency that was successfully treated with *** presentation:A 31-year-old Thai woman who had been diagnosed with livedoid vasculopathy 10 years previously presented with a 2-month history of worsening leg ulcers and failure to respond to aspirin,colchicine,and *** investigations confirmed protein c *** was initiated,and clinical improvement was achieved in 8 ***:When livedoid vasculopathy is confirmed by skin biopsy,additional investigations for hypercoagulable states should be performed to exclude secondary *** of the causes of livedoid vasculopathy can direct physicians to therapeutic options based on previously reported cases of successful *** patient,whose livedoid vasculopathy was caused by protein c deficiency,responded well to ***:protein c deficiency results in a hypercoagulable state,and affected patients can present with livedoid *** anticoagulant rivaroxaban has been beneficial in the treatment of livedoid vasculopathy.

关键词： livedoid vasculopathy protein c deficiency rivaroxaban hypercoagulability hypercoagulable state atrophie blanche

A Budd-chiari Syndrome Due to c protein deficiency: A case Report at YaoundéGeneral Hospital (cameroon)

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Open Journal of Gastroenterology 2024年第4期14卷 117-124页

作者： Antonin Wilson Ndjitoyap Ndam Gilles Gael Aghoagni Gouajio Armel Awana Tenone Danah Larry Tangie Ngek Mathurin Kowo Firmin Andoulo Ankouane Elie claude Ndjitoyap Ndam Department of Internal Medicine Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Came-roon Department of Internal Medicine and Peadiatrics Faculty of Health Sciences University of Buéa Buéa Cameroon Department of Biomedical Sciences Faculty of Sciences University of Ngaoundéré Ngaoundéré Cameroon

Primary Budd-chiari syndrome (BcS) is a spontaneously fatal disease characterized by an obstruction of the hepatic venous outflow tract due to thrombosis or a primary disease of the venous wall. The primary form of BcS is extremely rare. This is a disease mainly affecting young adults of both sexes. clinical manifestations are variable;they can be asymptomatic, acute, or subacute but mostly chronic. Several causes have been identified, such as myeloproliferative syndrome, antiphospholipid syndrome, paroxysmal nocturnal hemoglobinuria, and inherited thrombotic disorders. Data on primary BcS in Sub-Saharan Africa is rare as most publications available are case reports. In these reports, the causes are unknown with poor prognosis in most cases often leading to patient death. We herein present a case report of a male patient diagnosed with a primary BcS at Yaoundé General Hospital (cameroon) caused by a protein c deficiency who presented with ascites decompensating liver cirrhosis. Treatment was based on anticoagulants, diuretics and laxatives administration. Two years after the diagnosis, the patient is alive with clinical and paraclinical improvement.

关键词： Budd-chiari Syndrome Hepatic Veins Liver cirrhosis protein c deficiency cameroon

Systemic lupus erythematosus combined with primary hyperfibrinolysis and protein c and protein S deficiency:A case report

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World Journal of clinical cases 2021年第8期9卷 2008-2014页

作者： Yi-Xuan Liao Yan-Fei Guo Yu-Xia Wang Ai-Hua Liu chun-Li Zhang Department of Pulmonary and critical care Medicine Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Department of Rheumatology and Immunology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Department of Hematology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

BAcKGROUND Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by systemic involvement and multiple autoantibodies in the *** with protein c(Pc)and protein S(PS)deficiency are prone to *** contrast,patients with primary hyperfibrino-lysis tend to *** SUMMARY A 52-year-old female patient with bilateral pleural effusion was diagnosed with"tuberculous pleurisy"and treated with anti-tuberculosis drugs and *** coagulation-related laboratory results showed decreased fibrinogen,Pc activity,PS activity,and antithrombinШ*** immune-related laboratory results showed positive antinuclear antibody,anti-Smith antibody,anticardiolipin antibody(AcL),anti-β2-glycoprotein I antibody(aβ2GPI)and direct coomb’s test and decreased complement 3 and complement *** was performed and bloody pleural fluid was *** of the pleural biopsy showed lymphocytes,plasma cells,and a few eosinophils in adipose and fibrous connective *** of whole exome sequencing of blood showed no genetic mutations suggesting the presence of hereditary hematological *** patient was finally diagnosed with SLE and primary hyperfibrinolysis,and was treated with prednisolone,hydroxychloroquine,and compound *** Pc and PS deficiency in SLE might be related to AcL and aβ*** and primary hyperfibrinolysis can coexist in one patient,with both a risk of thrombosis and a risk of bleeding.

关键词： Systemic lupus erythematosus Primary hyperfibrinolysis Antiphospholipid antibody protein c deficiency protein S deficiency case report

Acute myocardial infarction after initially diagnosed with unprovoked venous thromboembolism: A case report

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World Journal of clinical cases 2023年第30期11卷 7497-7501页

作者： Jeongduk Seo Joonpyo Lee Yong Hoon Shin Albert Youngwoo Jang Soon Yong Suh Department of cardiology Gachon University Gil Medical CenterIncheon 405-760South Korea

BAcKGROUND protein c deficiency is typically associated with venous thromboembolism;however,arterial thrombosis has been reported in several *** report the case of a patient with pulmonary thromboembolism and deep vein thrombosis following acute myocardial infarction with high thrombus *** SUMMARY A 40-year-old man was diagnosed with pulmonary thromboembolism and deep vein thrombosis without any provoking *** patient was treated with anticoagulants for six months,which were then *** months after the discontinuation of anticoagulant therapy,the patient was hospitalized with chest pain and diagnosed with acute myocardial infarction with high thrombus *** tests revealed protein c deficiency associated with *** patient was treated with anticoagulants combined with dual antiplatelet agents for 1 year after percutaneous coronary intervention,and no recurrent events were reported during a follow-up period of 5 *** Recurrent thromboembolic events including acute myocardial infarction with thrombus should be considered an alarming sign of thrombophilia.

关键词： Venous thromboembolism thrombophilia protein c deficiency ST elevation myocardial infarction Anticoagulation case report