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Native and prosthetic septic arthritis in a university hospital in Saudi Arabia:A retrospective study

World Journal of Orthopedics 2024年第8期15卷 722-733页

作者： Reham Kaki Department of Internal Medicine King Abdulaziz UniversityJeddah 22230Saudi Arabia

BACKGROUND Septic arthritis,whether native or prosthetic,poses a significant challenge in clinical practice due to its potentially devastating *** its clinical importance,there remains a dearth of comprehensive studies and standardized diagnostic criteria,particularly in the Kingdom of Saudi *** To investigate the epidemiology,microbiological profiles,and clinical characteristics of native and prosthetic septic joints in the Saudi Arabian *** Medical records of patients diagnosed with septic arthritis between January 1,2015,and December 31,2022,were retrospectively *** regarding patient demographics,clinical presentation,microbiological cultures,treatment modalities,and outcomes were *** In a retrospective review of 52 cases of septic arthritis,a balanced gender distribution was observed(1:1 ratio),with the knee being the most commonly affected joint(80.8%).Methicillin-resistant Staphylococcus aureus predominated in native joints(24.2%),while Brucella *** more prevalent in prosthetic joints(21.1%).joint preservation was achieved in most cases(84.6%),with no significant difference in clinical features between native and prosthetic ***,certain comorbidities were more common in native joint cases,including renal impairment(P=0.002),hemodialysis(P=0.004),heart disease(P=0.013),and chronic liver disease(P=0.048).At the same time,osteoarthritis was more prevalent in prosthetic joint cases(P=0.013).Vancomycin was the most frequently used antibiotic(26.9%),and most patients received antibiotics before joint aspiration(57.7%).Surgical intervention,predominantly arthrotomy,was required in most cases(32.7%).Notably,a significant association was found between joint type and mortality(odds ratio=0.587,P=0.048),as well as the Charlson comorbidity index and mortality(P=0.001).CONCLUSION This study highlighted distinctive microbiological profiles and etiological factors in septic arthritis cases in the Sau

关键词： Septic arthritis Native joint prosthetic joint Epidemiology Diagnostic criteria Saudi Arabia

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Nuclear medicine and the failed joint replacement: Past, present, and future

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World Journal of Radiology 2014年第7期6卷 446-458页

作者： Christopher J Palestro Division of Nuclear Medicine Molecular Imaging Long Island Jewish Medical Center

Soon after the introduction of the modern prosthetic joint,it was recognized that radionuclide imaging provides useful information about these *** bone scan was used extensively to identify causes of prosthetic joint *** became apparent,however,that although sensitive,regardless of how the images were analyzed or how it was performed,the test was not specific and could not distinguish among the causes of prosthetic *** in anatomic imaging,notably cross sectional modalities,have facilitated the diagnosis of many,if not most,causes of prosthetic failure,with the important exception of *** has led to a shift in the diagnostic paradigm,in which nuclear medicine investigations increasingly have focused on diagnosing *** recognition that bone scintigraphy could not reliably diagnose infection led to the development of combined studies,first bone/gallium and subsequently leukocyte/bone and leukocyte/marrow *** leukocyte imaging,combined with bone marrow imaging is the most accurate(about90%)imaging test for diagnosing joint arthroplasty *** value not withstanding,there are significant disadvantages to this ***-vivo techniques for labeling leukocytes,using antigranulocyte antibodieshave been explored,but have their own limitations and the results have been ***(FDG)-positron emission tomography(FDG-PET)has been extensively investigated for more than a decade but its role in diagnosing the infected prosthesis has yet to be *** peptides bind to bacterial cell membranes and are infection *** suggest that these agents may be useful for diagnosing prosthetic joint infection,but large scale studies have yet to be *** for many years nuclear medicine has focused on diagnosing prosthetic joint infection,the advent of hybrid imaging with singlephoton emission computed tomography(SPECT)/electronic computer X-ray tomography technique(CT)a

关键词： Bone scintigraphy Positron emission tomography 18F-fluorodeoxyglucose F-18 Fluoride-positron emission tomography Gallium Infection Labeled leukocytes prosthetic joint

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