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Transperineal prostate biopsies for diagnosis of prostate cancer are well tolerated： a prospective study using patient-reported outcome measures

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Asian Journal of Andrology 2017年第1期19卷 62-66页

作者： Karan Wadhwa Lina Carmona-Echeveria Timur Kuru Gabriele Gaziev Eva Serrao Deepak Parasha Julia Frey Ivailo Dimov Jonas Seidenader Pete Acher Gordon Muir Andrew Doble Vincent Gnanapragasam Boris Hadaschik Christof Kastner Department of Urology Addenbrookes Hospital Cambridge UK Department of Urology University Hospital Heidelberg Germany Department of Biochemistry University of Cambridge Cambridge UK cancer Research Centre and Statistics and Epidemiology Unit Division of Health Sciences Warwick Medical School University of Warwick Coventry UK Department of Urology Southend University Hospital Southend UK Department of Urology Kings College Hospital London UK CamPARI prostate cancer Clinic Addenbrookes Hospital Cambridge UK.

We aimed to determine short-term patient-reported outcomes in men having general anesthetic transperineal （TP） prostate biopsies. A prospective cohort study was performed in men having a diagnostic TP biopsy. This was done using a validated and adapted questionnaire immediately post-biopsy and at follow-up of between 7 and 14 days across three tertiary referral hospitals with a response rate of 51.6%. Immediately after biopsy 43/201 （21.4%） of men felt light-headed, syncopal, or suffered syncope. Fifty-three percent of men felt discomfort after biopsy （with 95% scoring 〈5 in a 0-10 scale）. Twelve out of 196 men （6.1%） felt pain immediately after the procedure. Despite a high incidence of symptoms （e.g., up to 75% had some hematuria, 47% suffered some pain）, it was not a moderate or serious problem for most, apart from hemoejaculate which 31 men suffered. Eleven men needed catheterization （5.5%）. There were no inpatient admissions due to complications （hematuria, sepsis）. On repeat questioning at a later time point, only 25/199 （12.6%） of men said repeat biopsy would be a significant problem despite a significant and marked reduction in erectile function after the procedure. From this study, we conclude that TP biopsy is well tolerated with similar side effect profiles and attitudes of men to repeat biopsy to men having TRUS biopsies. These data allow informed counseling of men prior to TP biopsy and a benchmark for tolerability with local anesthetic TP biopsies being developed for clinical use.

关键词： attitude to rebiopsy patient-reported outcome measures patient satisfaction prostate cancer diagnosis transperineal biopsies transrectal biopsies

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Novel binders derived from an albuminbinding domain scaffold targeting human prostate secretory protein 94 （PSP94）

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Protein & Cell 2015年第10期6卷 774-779页

作者： Lucie Mareckova Hana Petrokova Radim Osicka Milan Kuchar Petr Maly Institute of Biotechnology Czech Academy of Sciences v. v. i. Vidernska 1083 142 20 Prague Czech Republic Institute of Microbiology Czech Academy of Sciences v. v. i. Videnska 1083 142 20 Prague Czech Republic

prostate secretory protein 94 （PSP94）, also known as β-microseminoprotein, is a product of the MSMB gene and one of the most abundant proteins found in human seminal plasma （Anklesaria et al., 2013）. This small cysteine-rich non-glycosylated protein is considered to be involved in regulation of many biological processes including male reproduction.

关键词： LNCaP Cell prostate cancer diagnosis LNCaP prostate cancer Cell Line Thermal Shift Assay PSP94 Protein

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