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A multicenter prospective study on the management of hepatoblastoma in children:a report from the Chinese Children's Cancer Group

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World Journal of Pediatrics 2024年第6期20卷 590-601页

作者： Meng-Jie Tang Xiao-Li Ma Xiang-Ling He Wei-Hua Pan Xiao-Hong Zhang Sha-Yi Jiang Ju Gao Fu Li Wei Yao Song Gu Wei-Ling Zhang Qiang Zhao Shi-Hao Huang Yong-Jun Fang Wei Liu Hui-Zhong Niu Chun-Mei Wang Li-Rong Sun Hui Gao Yun-Peng Dai Shun-Gen Huang Zhi-Yong Zhong Xi-Ge Wang Zhong-Rong Li Liang-Chun Yang Ye-Ming Wu Huan-Min Wang Xin Sun Xiao-Jun Yuan Department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadYangpu DistrictShanghai 200092China Medical Oncology Department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Hematology/Oncology Children's Medical CenterHunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 41005China Department of Pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Hematology/Oncology Guangzhou Women and Children's Medical CenterNational Children's Medical Center for South Central RegionGuangzhou 510623China Department of Hematology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China Department of Hematology/Oncology Qilu Children's Hospital of Shandong UniversityJinan 250022China Department of Pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China Department of General Surgery Shanghai Children's Medical Center(National Children's Medical Center-Shanghai)Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Pediatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Hematology/Oncology Children's Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/Oncology Henan Children's HospitalZhengzhou 450018China Department of Pediatric General Surgery Hebei Children's Hospital of Hebei Medical UniversityShijiazhuang City 050031China Children's Hospital the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Paediatric

Background This study aimed to identify survival risk factors in Chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group(CCCG)in *** A multicenter,prospective study that included 399 patients with HB from January 2015 to June 2020 was *** demographics,treatment protocols,and other related information were *** regression models and Kaplan-Meier curve methods were *** The 4-year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,*** 4-year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,*** 4-year 0S was 100%,97.3%,94.4%,and 86.8%,*** regression analysis found that age,tumor rupture(R+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 299 patients had complete remission,and 19 *** with declining alpha-fetoprotein(AFP)>75%after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those≤75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2016 ***≥8 years,R+,and E+were independent risk factors for *** with a declining AFP>75%after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.

关键词： Alpha-fetoprotein Hepatoblastoma Multicenter prospective study Survival

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Hybrid argon plasma coagulation for the treatment of Barrett’s esophagus:A prospective,multicenter study

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World Journal of Clinical Cases 2024年第19期12卷 3866-3872页

作者： Dong Wang Yan Chen Feng Ji Jian-Wei Hu Ping-Hong Zhou Shu-Chang Xu Ying Chen Li-Ping Ye Guo-Liang Ye Rui Li Zhao-Shen Li Department of Gastroenterology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200011China Department of Gastroenterology Changhai HospitalShanghai 200438China Department of Gastroenterology The First Affiliated Hospital Zhejiang University School of MedicineHangzhou 311399Zhejiang ProvinceChina Endoscopy Center Zhongshan HospitalFudan UniversityShanghai 200032China Endoscopy Center Tongji Hospital of Tongji UniversityShanghai 200092China Department of Gastroenterology Taizhou Hospital of Zhejiang ProvinceTaizhou 318001Zhejiang ProvinceChina Department of Gastroenterology The Affiliated Hospital of Medicine SchoolNingbo UniversityNingbo 315021Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND The incidence of Barrett’s esophagus(BE)in China is lower compared to the Western ***,studies conducted in the Chinese population has been *** current treatment options available for BE treatment includes argon plasma coagulation(APC),radiofrequency ablation and cryoablation,all with varying degrees of *** To determine the efficacy and safety of HybridAPC in the treatment of *** The study cohort consisted of patients with BE who underwent HybridAPC ablation *** procedures were performed by seven endoscopists from different tertiary *** duration of the procedure,curative rate,complications and recurrent rate by 1-year follow-up were *** Eighty individuals were enrolled for treatment from July 2017 to June 2020,comprising of 39 males and 41 females with a median age of 54 years(range,30 to 83 years).The technical success rate of HybridAPC was 100%and the overall curative rate was 98.15%.No severe complications occurred during the *** cases were classified as short-segment BE and long-segment *** with short-segment BE were all considered cured without ***-six patients completed the one-year follow-up without ***-four percent had mild dysplasia which were all resolved with one post-procedural *** mean duration of the procedure was 10.94±6.52 *** Treatment of BE with HybridAPC was found to be a simple and quick procedure that is safe and effective during the short-term follow-up,especially in cases of short-segment *** technique could be considered as a feasible alternative ablation therapy for BE.

关键词： Barrett’s esophagus Hybrid argon plasma coagulation Ablation treatment prospective study Multicenter study

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Use of the UPOINT phenotype system in treating Chinese patients with chronic prostatitis/chronic pelvic pain syndrome： a prospective study

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Asian Journal of Andrology 2015年第1期17卷 120-123,I0010,I0011页

作者： Xiao Guan Department of Urology Xiangya Hospital Central South University Changsha 410008 China

The urinary, psychosocial, organ-specific, infection, neurological/systemic and tenderness （UPOINT） phenotype system has been validated to be an effective phenotype system in classifying patients with chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS） in western populations. To validate the utility of the UPOINT system and evaluate the effect of multimodal therapy based on the UPOINT system in Chinese patients with CPICPPS, we performed this study. Chinese patients with CP/CPPS were prospectively offered multimodal therapy using the UPOINT system and re-examined after 6 months. A minimum 6-point drop in National Institutes of Health-Chronic Prostatitis Symptoms Index （NIH-CPSI） was set to be the primary endpoint. Finally, 140 patients were enrolled in the study. The percentage of patients with each domain was 59.3%, 45.0%, 49.3%, 22.1%, 37.9%, and 56.4% for the UPOINT, respectively. The number of positive domains significantly correlated with symptom severity, which is measured by total NIH-CPSI scores （r = 0.796, P 〈 0.001）. Symptom duration was associated with a greater number of positive domains （r = 0.589, P〈 0.001）. With 6 months follow-up at least, 75.0% （105/140） had at least a 6-point improvement in NIH-CPSI after taking the therapy. All NIH-CPSI scores were significantly improved from original ones： pain 10.14 ± 4.26 to 6.60 ± 3.39, urinary 6.29 ± 2.42 to 3.63 ± 1.52, quality of life 6.56 ± 2.44 to 4.06 ± 1.98, and total 22.99 ± 7.28 to 14.29 ±5.70 （all P〈 0.0001）. Our study indicates that the UPOINT system is clinically feasible in classifying Chinese patients with CP/CPPS and directing therapy.

关键词： chronic pelvic pain syndrome chronic prostatitis drug therapy prospective study UPOINT

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Combined Effects of Family History of Cardiovascular Disease and Serum C-reactive Protein Level on the Risk of Stroke: A 9.2-year prospective study among Mongolians in China

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Biomedical and Environmental Sciences 2017年第9期30卷 632-640页

作者： ZHU Zheng Bao HUANGFU Xin Feng ZHONG Chong Ke ZHOU Yi Peng TIAN Yun Fan BUREN Batu XU Tian WANG Ai Li LI Hong Mei ZHANG Ming Zhi ZHANG Yong Hong Department of Epidemiology School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Medical College of Soochow University Department of Epidemiology Tongliao Center for Disease Prevention and Control Department of Neurology Affiliated Hospital of Nantong University

Objective We aimed to evaluate the combined effect of a family history of cardiovascular disease（CVD） and high serum C‐reactive protein（CRP） on the stroke incidence in an Inner Mongolian population in China. Methods A prospective cohort study was conducted from June 2002 to July 2012, with 2,544 participants aged 20 years and over from Inner Mongolia, China. We categorized participants into four groups based on the family history of CVD and CRP levels. Results We adjusted for age; sex; smoking; drinking; hypertension; body mass index; waist circumference; and blood glucose, triglycerides, low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol levels. Compared with the group with no family history of CVD/low CRP levels, the group with family history of CVD/high CRP levels had a hazard ratio（HR） of 1.78 [95% confidence interval（CI）, 1.03‐3.07; P = 0.039] of stroke, and an HR of 2.14（95% CI, 1.09‐4.20; P = 0.027） of ischemic stroke. The HRs of hemorrhagic stroke for the other three groups were not statistically significant（all P 〉 0.05）. Conclusion Participants with both a family history of CVD and high CRP levels had the highest stroke incidence, suggesting that high CRP levels may increase stroke risk, especially of ischemic stroke, among individuals with a family history of CVD.

关键词： Family history of cardiovascular disease C‐reactive protein Stroke prospective study

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Arthroscopic findings after manipulation under anesthesia in idiopathic capsulitis of the shoulder:A prospective study

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World Journal of Clinical Cases 2023年第34期11卷 8147-8152页

作者： Sai Krishna Mlv Ravi Mittal Nitin Chauhan Department of Orthopaedics Aayush HospitalEluru 534002Andhra PradeshIndia Department of Orthopaedics All India Institute of Medical SciencesNew Delhi 110029India

BACKGROUND Manipulation under anesthesia(MUA)of the shoulder joint is a commonly used method for the treatment of adhesive *** it has been known to be associated with a variety of complications,there is a paucity of studies describing the arthroscopic findings after *** To describe the arthroscopic findings in patients with idiopathic adhesive capsulitis of the shoulder after *** We recruited 28 patients with idiopathic adhesive capsulitis who underwent arthroscopic capsular *** of the shoulder was performed under anesthesia in all of these patients before capsular ***-articular findings were recorded during arthroscopic capsular release in these *** All patients showed the presence of ***-seven patients showed tears in the capsule on the anterior *** patient had an avulsion of the anterior rim of the glenoid and labrum following the *** patients had partial rotator cuff tears,and one patient showed a superior labrum anterior posterior lesion,which was not diagnosed preoperatively on magnetic resonance *** MUA leads to rupture of the capsule,which is the desired ***,the site of rupture of the capsule is dependent on the maneuvers of *** addition,partial tears of the rotator cuff and osteochondral fractures of the glenoid can also occur.

关键词： Frozen shoulder Arthroscopy Manipulation under anesthesia prospective study

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Quality of life after colorectal surgery:A prospective study of patients compared with their spouses

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 1050-1062页

作者： Gökçe Aylaz Cihangir Akyol Akın Fırat Kocaay Derya Gökmen Ayşe Burcu Yavuzarslan Ayhan Bülent Erkek Mehmet Ayhan Kuzu Department of Surgery Sisli Memorial HospitalIstanbul 34385Turkey Department of Surgery Ankara University School of MedicineAnkara 06100Turkey Department of Biostatistics Ankara University School of MedicineAnkara 06100Turkey

BACKGROUND Although radical surgery for colorectal cancer improves the oncological outcomes,a significant portion of patients suffer from alterations in their quality of life(QoL).There are many studies investigating the QoL of patients who have colorectal cancer but none of these focus on the QoL of *** To compare the QoL of patients after colorectal surgery to the QoL of *** This prospective study consisted of patients who were married and who underwent surgery at the University of Ankara,Department of Surgery between March 2006 and November ***’spouses were also *** study was approved by the Ethics Committee of the Faculty of Medicine,Ankara University,and all patients provided written informed *** study included patients who underwent curative surgery for colorectal carcinoma[n=100;abdominoperineal excision(n=33),low anterior resection(n=33),left hemicolectomy(n=34)]and their spouses(n=100).The patients and spouses completed the Medical Outcome study 36-item Short Form Survey(SF-36)and the World Health Organization Disability Assessment Schedule II(WHODAS-II)preoperatively and at postoperative months 15 to *** During this 4.5-year study period,273 patients with sigmoid or rectal cancer were admitted to the *** these patients,119 were eligible and willing to *** patients had either systemic or locally inoperable disease,three patients had a severe surgical complication,and five patients were lost to ***,a total of 100 patients completed the follow-up *** was a statistically significant positive correlation between the disability scores of patients and the scores of their spouses for some of the WHODAS-II subscales,such as“self-care,”“life activities,”and“participation in society,”as well as for the total WHODAS-II *** was also a positive correlation between the QoL of patients and the QoL of their spouses in most of the SF-36 *** signif

关键词： Quality of life Colorectal surgery Patients'spouses prospective study Male spouses Preoperative counseling

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Peanut consumption and reduced risk of colorectal cancer in women:A prospective study in Taiwan

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World Journal of Gastroenterology 2006年第2期12卷 222-227页

作者： Chih-Ching Yeh San-Lin You Chien-Jen Chen Fung-Chang Sung Department of Risk Management China Medical University College of Public Health Taichung 404Taiwan China Institutes of Epidemiology National Taiwan University College of Public Health Taipei 100Taiwan China Institute of Environment Health China Medical University College of Public Health Taichung 404 Taiwan and Institute of Environment Health National Taiwan University College of Public Health Taipei 100 Taiwan China

AIM： To examine whether peanut consumption is associated with a reduced risk of colorectal cancer in a prospective cohort with a 10-year follow-up. METHODS： In 1990-1992, residents （12026 men and 11917 women aged 30 to 65 years） in 7 townships, Taiwan, were interviewed and recruited into a cancerscreening cohort and annually followed up. Colorectal cancer cases in this cohort were identified from cancer registry and death certificates. Incidence rates of this disease by the end of 2001 were calculated by gender for the primary study variable and covariates. The dietary intake was assessed by means of weekly food frequency measures, including frequently consumed food groups and folk dishes including sweet potato, bean products, peanut products, pickled foodstuffs, nitrated or smoked foodstuffs. RESULTS： During the study period, 107 new colorectal cancer cases （68 men and 39 women） were confirmed. The multivariate Cox＇s proportional hazard model showed that the relative risk （RR） of peanut consumption was 0.73 [95% confidence interval （CI） = 0.44-1.21] for men and 0.42 （95% CI = 0.21-0.84） for women. However, frequent intake of pickled foodstuffs was harmful for women （RR= 2.15, 95% CI=0.99-4.65）. The risk of colorectal cancer was also elevated among cigarette smokers but not significant （P〈 0.05）.CONCLUSION： This study suggests that frequent intake of peanut and its products may reduce colorectal cancer risk in women, demonstrating the anti-proliferating effect of peanut intake.

关键词： Peanuts Colorectal cancer Diet Gender difference prospective study Taiwan

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Characteristics and Risk factors of Psychosomatic Symptoms Related to Female Tubal Sterilization in Rural Area in Hunan Province, China: A prospective study

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Journal of Reproduction and Contraception 2002年第1期13卷 37-52页

作者：刘破资岳伟华郝伟杨德森凌天牖张友明彭光辉武昆刘红华苏中华王厚亮谢永标 Department of Mental Health the Second Xiangya Hospital Central South UniversityChangsha 410011 China Department of Family Planning of Hunan Province Changsha 410011 China

Objectives To study characteristics of psychosomatic symptoms related to sterilization, to find out risk factors and their roles ascribed to psychosomatic symptoms, and to establish a mathematic model for screening out susceptible women. Methods: This study enrolled 776 women in rural area at three counties of Linxiang, Qiyang, Changsha of Hunan province in China between February 1990 and April 1992. Brief Neurosis Screening Scale (BNSS), Symptom Checklist 90 (SCL-90), sensitivity to pain, suggestibility were used to indicate subjects' psychological status. Logistic regression model and retrograde discriminant analysis were applied to develop a mathematical model. Results: Prevalence of psychosomatic reactions or symptoms was 54.8% before sterilization, 26.6% at three months and 16.4% at one year after operation respectively. Psychosomatic symptoms were verified to be the result of joint effects of multiple risk factors. The following risk factors were associated with postoperative symptoms: anger-hostility (RR=33.71), high suggestibility (RR=4.53), high neuroticism (RR=3.44), sensitivity to pain (RR=2.14) and operative sites (RR=2.05). A mathematical model to estimate the probability of developing psychosomatic symptoms in sterilization was ***: More than half of women suffered from psychosomatic reactions before operation, and some of them did not recover after operation. The postoperative psychosomatic symptoms are the joint effect of multiple risk factors.

关键词： female tubal sterilization psychosomatic symptom susceptible prospective study

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THE prospective study OF RELATIONSHIP BETWEEN LOW SELENIUM AND KASHIN-BECK DISEASE

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Journal of Pharmaceutical Analysis 1999年第1期13卷 2-8,19页

作者：郭雄丁德修曾令霞于志道陈风石赵增勤王玖姓毕华银

The relationship of causeresult between low selenium (Se) and KashinBeck disease (KBD) was probed by the prospective study of epidemiological method with regarding lowSe as an exposure factor in this paper. 597 healthy children lived in KBD areas with low, middle and high prevalence were divided into the lowSe exposed group and the nonlowSe exposed group according to their Se content in hair. The lowSe exposed group was divided into three subgroups, such as Se content in hair110 ng/g, 110 ng/g

关键词： KashinBeck disease selenium new case prospective study

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Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study

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Frontiers of Medicine 2020年第6期14卷 802-810页

作者： Di Cheng Chunyan Hu Rui Du Hongyan Qi Lin Lin Xueyan Wu Lina Ma Kui Peng Mian Li Min Xu Yu Xu Yufang Bi Weiqing Wang Yuhong Chen Jieli Lu Department of Endocrine and Metabolic Diseases Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Endocrine and Metabolic Diseases Ruijin Hospital NorthRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 201821China

The association between serum uric acid and the risk of incident diabetes in Chinese adults remains *** study aimed to investigate this association in a community-dwelling population aged≥40 years in Shanghai,*** glucose tole3rance test was conducted during baseline and follow-up *** risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk.A total of 613(10.3%)incident diabetes cases were identified during the follow-up visit after 4.5 *** plasma glucose,postload glucose,and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid(all Ps<0.05).The incidence rate of diabetes increased across the quartiles of serum uric acid(7.43%,8.77%,11.47%,and 13.43%).Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid(odds ratio(95%confidence interval)=1.36(1.06−1.73)).Stratified analysis indicated that the association was only observed in ***,serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women.

关键词： incident diabetes prospective study uric acid

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