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Clinical Assessment of the Use of propinox hydrochloride and Scopolamine hydrochloride in the Treatment of Abdominal Colic: A Retrospective, Comparative Study

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International Journal of Clinical Medicine 2016年第7期7卷 474-480页

作者： Helio Rzetelna Carlos Frederico Porto Alegre Rosa Mario Kirzner Lucas Pereira Jorge de Medeiros Camila Melo Marcia Gonçalves Ribeiro Lisa Oliveira José Galvão Alves Mauro Geller Gastroenterology Department Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil Clinical Medicine Department Centro Universitário Volta Redonda (UNIFOA) Volta Redonda Brazil Clinical Medicine and Gastroenterology Department Universidade Estácio de Sá (UNESA) Rio de Janeiro Brazil Clinical Medicine Department Escola de Medicina Souza Marques Rio de Janeiro Brazil 5Inflammatory Bowel Diseases Outpatient Unit-18 ª enfermaria da Santa Casa da Misericórdia do Rio de Janeiro Rio de Janeiro Brazil Federação Brasileira de Gastroenterologia S&atildeo Paulo Brazil Grupo de Estudos de Doenças Inflamatórias Intestinais Rio de Janeiro Brazil UNESA Rio de Janeiro Brazil Gastroenterology Post-Graduation Program-PUC-Rio Rio de Janeiro Brazil Neurology Post-Graduation Program Universidade Federal do Estado do Rio de Janeiro (UERJ) Rio de Janeiro Brazil Pharmacology Department—UFRJ Rio de Janeiro Brazil Medical Genetics Service IPPMG-Universidade Federal Rio de Janeiro Rio de Janeiro Brazil Immunology Department Teresópolis Medical School (UNIFESO) Teresópolis Brazil Clinical Immunology Instituto de Pós-Gradua&ccedil&atildeo Médica Carlos Chagas (IPGMCC) Rio de Janeiro Brazil

Objectives: The purpose of this study was to evaluate and compare the use of propinox hydrochloride and scopolamine hydrochloride in patients presenting abdominal colic (abdominal pain), in terms of treatment efficacy and tolerability. Material & Methods: This was an analytical, retrospective, comparative study based on hospital records of outpatients treated at Serviço de Clínica Médica do Hospital das Clínicas Costantino Otaviano (HCTCO) and at Santa Casa de Misericórdia do Rio de Janeiro, from 1988-1998. Subjects were divided into two groups: patients from Group 1 were treated with propinox hydrochloride, while patients from Group 2 were treated with scopolamine hydrochloride. Statistical analysis was performed using GraphPad Prism version 5.0. For comparison of categorical variables, we used the chi-squared or Fisher’s test, while continuous variables were analyzed using ANOVA or the Student’s T test. Results: A total of 1042 subjects were included, of which 525 were allocated to Group 1 and 517 to Group 2. Mean treatment duration was 9.166 days (±4.208) in Group 1 and 8.795 days (±5.052) in Group 2, with no statistically significant difference in treatment duration between the two groups (p = 0.198). All subjects in Group 1 were treated with propinox 10 mg (2 coated tablets, three times per day) while all subjects in Group 2 were treated with scopolamine hydrochloride 10 mg (2 coated tablets, three times per day). There were no statistically significant between-group differences in weight, BMI, heart rate, and respiratory rate at pre- and post-treatment;with the exception of higher post-treatment systolic blood pressure in Group 1, blood pressure measures also remained homogenous. Adverse events were reported among both treatment groups with no significant between-group difference in incidence (p = 0566). At pretreatment, pain intensity was more severe in Group 1 (p = 0.0257), while at post-treatment, there was no statistically significant difference betw

关键词： Abdominal Colic propinox hydrochloride Scopolamine hydrochloride

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