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Decrease of Matrix Plasticity promotes Fibroblast Activation in Fibrosis

医用生物力学 2019年第A1期34卷 126-127页

作者： Yuanbo Jia Yanzhong Wang Lele Niu Hang Zhang Jin Tian Dengfeng Gao Xiaohui Zhang Tian Jian Lu Jin Qian Guoyou Huang Feng Xu The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an710049China Bioinspired Engineering and Biomechanics Center(BEBC) Xi’an Jiaotong UniversityXi’an710049China Department of Engineering Mechanics Key Laboratory ofSoft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhou310027China Department ofCardiology The Second Affiliated HospitalXi’an Jiaotong University School of MedicineMOE Key Laboratory of Multifunctional Materials and StructuresXi’an Jiaotong UniversityXi’an710049China State Key Laboratory ofMechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China Nanjing Center for Multifunctional Lightweight Materials and Structures Nanjing University of Aeronautics andAstronauticsNanjing21006China

This work identified the important role of matrix mechanical plasticity in mediating fibroblast *** existing studies have highlighted the important effects of biochemical cues(e.g.,transforming growth factor-β1)and mechanicalstiffness on fibroblast *** results indicated that self-assembled collagen hydrogels showed high plasticity and in which fibroblasts remain ***,when we decreased the plasticity of collagen hydrogels by increasing covalent crosslinking,fibroblasts showed a significant fibrotic response as reflected by the increasedα-SMA *** the material systems we constructed have low and the same initial modulus,this process is stiffness *** it has been reported that covalently crosslinked hydrogels are more difficult to degrade and matrix degradability has an important impact on cell behaviors,no significant changes of fibroblast activation were observed when proteases were broadly inhibited in our ***,the hydrogels we constructed showed similar plastic behaviors under creep and recovery tests compared to native normal and fibrotic *** highlight the importance of matrix plasticity in mimicking the mechanical microenvironment of native fibrotic ***,we found that the enhanced fibroblast activation in low plastic matrix is mediated through integrin-actin pathway and nuclear localization of *** high plastic collagen,matrix cannot provide effective resistance to actin contraction because of the rupture of weak crosslinks and the slippage of local *** the contrary,in low plastic collagen,deformation energy can be stored in the network due to the existence of strong covalent crosslinks,thus enabling the build-up of cell traction and the formation of a robust cell-matrix *** of inhibiting or promoting cytoskeletal contractility and CGMD simulation both verified the above *** results clarify plasticity changes on

关键词： Decrease Matrix Plasticity promotes Fibroblast Activation Fibrosis Matrix

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The Bank Industry promotes Healthy Trade Development

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China's Foreign Trade 2019年第3期 44-46页

作者： Lily Wang 不详

The world trade situation is still changing and complicated,as a wave of trade protectionism surges and regional political risks *** situations have added a lot of uncertainties to the world trade and *** will the bank i’ndustry behave to promote globalization and the development of world trade and support world economic opening-up through the advancement of Belt and Road Initiative?

关键词： ICC The Bank Industry promotes Healthy Trade Development

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Malaysia promotes Various Convenient Measures to Attract More Chinese Tourists——Interview with Zalizam Zakaria, Tourism Minister of Malaysia Embassy

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China's Foreign Trade 2019年第3期 17-19页

作者： Guo Yan 不详

Malaysia has many worldclass tourist spots,like Kuala Lumpur,Malacca,Pulau Langkawi and ***’s musang king is the top delicious’food for world *** to the recent data released by Malaysia’s Ministry of Tourism,China ranked the third in terms of number of tourists visiting Malaysia in 2018,with about 2.94 million tourists in *** year marks the 45th anniversary of the establishment of diplomatic relations between China and Malaysia.

关键词： Interview with Zalizam Zakaria Malaysia promotes Various Convenient Measures to Attract More Chinese Tourists Tourism Minister of Malaysia Embassy

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IPA1 promotes highyield and resistance to rice blast disease

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Science Foundation in China 2018年第4期26卷 1-1页

With supports from the National Natural Science Foundation of China,National Key Research and Development Program of China,and Program for New Century Excellent Talents in University from the Ministry of Education in China,the research team led by *** XueWei(陈学伟)at the Rice Research Institute,Sichuan Agricultural University,and *** JiaYang(李家洋)at the State Key Laboratory of Plant Genomics and National Center for Plant Gene Research,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,uncovered that Ideal Plant Arehiteturel (IPA1) could promote both yield and immunity in rice,which was published in Science (2018,361:1026-1028).

关键词： IPA1 promotes resistance

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SYPAFFC actively promotes exchanges between Chinese and South Korean youths at National Stadium

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Voice of Friendship 2018年第4期 7-7页

作者： Shenyang Friendship Association Shenyang Friendship Association

A 24-member delegation from Daejeon, South Korea, visited Shenyang from Oct 22 to 26. The Shenyang People’s Association for Friendship with Foreign Countries has organized a series of exchange activities for telling ... 详细信息

关键词： SYPAFFC actively promotes Chinese South Korean

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A Green Start

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Beijing Review 2019年第51期62卷 26-27页

作者： Wang Hairong China Institute of International Studies

The world’s largest horticultural expo promotes ecological progress The International Horticultural Exhibition 2019 lifted its veil and opened its door to visitors in Beijingo n April *** with a breathtaking evening gala the night before,the expo site wasfi lled with lights that lined tree canopies and building contours,while songs and dances embodying green ideas and the cultures of China and other participating countries fascinated the *** performance,staged on a gigantic LED waterside arena,culminated with a dazzling fi reworks show.

关键词： A Green Start horticultural expo promotes Horticultural Exhibition

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