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Identification of TSS in the Human Genome Based on a RBF Neural Network

International Journal of Automation and computing 2006年第1期3卷 35-40页

作者： Zhi-Hong Peng Jie Chen Li-Jun Cao Ting-Ting Gao College of Information Science and Technology Beijing Institute of Technology Beijing 100081 PRC

The identification of functional motifs in a DNA sequence is fundamentally a statistical pattern recognition problem. This paper introduces a new algorithm for the recognition of functional transcription start sites （TSSs） in human genome sequences, in which a RBF neural network is adopted, and an improved heuristic method for a 5-tuple feature viable construction, is proposed and implemented in two RBFpromoter and ImpRBFpromoter packages developed in Visual C＋＋ 6.0. The algorithm is evaluated on several different test sequence sets. Compared with several other promoter recognition programs, this algorithm is proved to be more flexible, with stronger learning ability and higher accuracy.

关键词： promoter recognition human genome transcription start site RBF neural network.

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Structural basis for transcription initiation by E. coli σE

Structural basis for transcription initiation by E. coli σE

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Chengli Fang Lingting Li Liqiang Shen Jing Shi Yu Feng Yu Zhang Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of Sciences University of Chinese Academy of Sciences Department of Biochemistry and Molecular Biology School of MedicineZhejiang University

Bacterial RNAP uses extra-cytoplasmic function(ECF) σ factors to regulate gene *** σ is a well-studied and vital ECF σ factor,which controls expression of a set of genes in response to various environmental and cellular events causing cell-envelop ***,it remains elusive how σ interacts with RNAP core enzyme,and how the σ-RNAP holoenzyme initiates transcription of its regulated *** this study,we have determined a cryo-EM structure of *** complex comprising σ(*** σ-RPo).The structure revealskey interactions essential for assembly of σ-RNAP holoenzyme and for promoter recognition and ***,the structure shows that the non-conserved linker region connecting N-terminal and C-terminal domains(σ2/σ4 linker) of σ threads into the active-center cleft and exits through the RNA exit *** bioinformatic,biochemical,and structural analysis suggest that the highly divergent σ2/σ4 linker of ECF σ factors probably interact with RNAP in the same mode and plays essential roles during transcription initiation.

关键词： RNA polymerase Extra-Cytoplasmic Function σ factors transcription initiation promoter recognition

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