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promestriene Affects GREB1 Expression in Estrogen Sensitive Breast Cancer Cells

Journal of Cancer Therapy 2015年第9期6卷 767-772页

作者： Alvin J. O. Almodovar Xiang Zhu Sally A. Litherland David A. Decker Florida Hospital Cancer Institute Research & Development Division Orlando FL USA University of Central Florida College of Medicine Orlando FL USA

promestriene (3-propyl ethyl, 17B-methyl estradiol) is a synthetic estrogen analogue with reported minimal systemic absorption which has been suggested for topical treatment of vaginal atrophy. promestriene’s ability to stimulate proliferation and estrogen responsive gene expression was analyzed in estrogen receptor (ER+) positive breast cancer cell lines MCF-7, T-47D, and BT-474 using CFSE flow cytometric analysis, and quantitative RT-PCR analysis of GREB1 RNA expression, an estrogen responsive gene involved in estrogen receptor alpha expression. In estrogen replete conditions, promestriene did not stimulate proliferation even at high concentrations (100,000 pg/ml). However, anti-estradiol depletion allowed low dose promestriene (2 - 10 pg/ml) to stimulate GREB1 expression in all three cell lines at levels equal to that induced by estradiol (BT-474) or significantly higher than estradiol (MCF7 and T-47D). These findings suggest that promestriene has the potential to support estrogen like cell signaling, a possible contraindication for use in treatment of vaginal atrophy associated with breast cancer aromatase inhibitor therapy.

关键词： Breast Cancer Survivor Estrogen Receptor Positive Hormone Therapy Side Effects promestriene

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Perceived Efficacy of Vaginal Dryness Relief: A Comparative Clinical Study between Sodium hyaluronate vaginal gel1vs. promestriene cream2

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Advances in Sexual Medicine 2017年第1期7卷 34-43页

作者： Eduardo de Oliveira Duque-Estrada Vivian Pessoto Rosa Mariane Martins Mosca Heliara Lopes do Nascimento Hospital Municipal Dr. Moysés Deutsch S&atilde o Paulo Brazil Allergisa CRO Team S&atilde o Paulo Brazil

In the study, we report the comparative efficacy of the sodium hyaluronate gel vaginal application and promestriene cream which were tested to treat the gynecological symptoms of people who suffered from vaginal dryness. Method: 35 patients applied sodium hyaluronate vaginal gel one time a day for a period of two times a week during three weeks and other 33 patients using promestriene cream applied it every day for a period of three weeks also. Results: No significant difference was observed between vaginal application of sodium hyaluronate gel and promestriene cream, regarding both, as regarding the dryness of the intimate mucosa (p = 0.786), the attribute of moisturizing properties to the intimate mucosa (p = 0.142), the comfort sensation (p = 0.528), and no significant difference was observed regarding the fragrance of the product (p = 0.088). Conclusion: The similar results between vaginal application of both products support the use of sodium hyaluronate vaginal gel (Lubrinat®) in the initial approach of symptoms of vaginal dryness.

关键词： Vaginal Dryness Menopause Sodium Hyaluronate promestriene

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