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proliferative vitreoretinopathy and its relationship with inflammatory serum biomarkers

International Journal of Ophthalmology(English edition) 2024年第9期17卷 1659-1664页

作者： Victor Alejandro Martinez Pacheco Sergio Rojas Juarez Braulio Hernan Velasco Sepulveda Abel Ramirez Estudillo Hospital de Nuestra Señora de la Luz Retina and Vitreous DepartmentMexico City 06030Mexico Instituto de Oftlamología FAP Conde de Valenciana Mexico City 06080Mexico

AIM:To analyze if a relationship between levels ofinflammatory serum biomarkers and severity of primaryproliferative vitreoretinopathy(PVR)***:A retrospective case-control *** adult patients with rhegmatogenous retinaldetachment and primary PVR were included in the *** the control group,healthy adults who underwentcataract surgery were *** grade of PVR wasclassified according to the Retinal Society *** samples were obtained before surgery,and processed in MYTHIC *** of interest wereneutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyteratio(PLR),and lymphocyte-to-monocyte ratio(LMR),thetime between the decrease in visual acuity and surgery,PVRgrade,type of surgery,final best corrected visual acuity,andrate of ***:Totally 240 patients were included,120 ineach group,79(65.8%)and 56(46.7%)were male in thePVR and control group,*** A had greaterlevels of monocytes(0.28±0.18 vs 0.12±0.32,P=0.002),neutrophils(4.59±1.51 vs 3.92±1.27,P=0.006),and LMR(9.32±4.42 vs 7.43±3.90,P=0.01).PVR B had a greatermonocyte count(0.30±0.13 vs 0.12±0.32,P=0.001),andPVR C demonstrated higher levels in monocytes(0.27±0.12vs 0.12±0.32,P=0.004),neutrophils(4.39±1.13 vs3.92±1.27,P=0.004),and LMR(9.63±3.24 vs 7.43±3.90,P=0.002)compared to control,*** LMR cut-offvalue of 9.38 predicted PVR with a sensibility of 54.2%andspecificity of 77.5%and NLR cut-off of 1.70 predicted PVRwith a sensibility of 62%and specificity of 54.2%.CONCLUSION:Patients with primary PVR demonstrategreater neutrophil,monocyte,and LMR levels than thecontrol ***-off values obtained from ratios could beuseful in a clinical setting when no posterior view of thefundus is possible due to media opacity.

关键词： biomarkers proliferative vitreoretinopathy retinal detachment inflammation serum

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Expression of IGFBP-6 in a proliferative vitreoretinopathy rat model and its effects on retinal pigment epithelial cell proliferation and migration

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 27-33页

作者： Hong-Mei Zhao Min-Jie Sheng Jing Yu Department of Ophthalmology the Tenth People's Hospital of Tongji University

AIM: To investigate the expression of insulin-like growth factor binding protein-6(IGFBP-6) in a proliferative vitreoretinopathy(PVR) model and its effects on proliferation and migration in retinal pigment epithelial(RPE) cells. ·METHODS: A PVR Wistar rat model was established by the intravitreal injection of RPE-J cells combined with platelet-rich plasma(PRP). The expression levels of IGFBP-6 were tested by ELISA. ARPE-19 cell proliferation was evaluated by the MTS method,and cell migration was evaluated by wound healing assays. ·RESULTS: The success rate of the PVR model was 89.3%(25/28). IGFBP-6 was expressed at higher levels in the vitreous,serum and retina of rats experiencing advanced PVR(grade 3) than in the control group(vitreous: 152.80 ±15.08ng/mL vs 105.44 ±24.81ng/mL,P > 0.05; serum: 93.48 ±9.27ng/mL vs 80.59 ±5.20ng/mL,P < 0.05; retina: 3.02±0.38ng/mg vs 2.05±0.53ng/mg,P <0.05). In vitro,IGFBP-6(500ng/mL) inhibited the IGF-II(50ng/mL) induced ARPE-19 cell proliferation(OD value at 24h: from 1.38±0.05 to 1.30±0.02; 48h: from 1.44±0.06 to 1.35± 0.05). However,it did not affect basal or VEGF-,TGF-β-and PDGF-induced cell proliferation. IGFBP-6(500ng/ml) reduced the IGF-II(50ng/mL)-induced would healing rate [24h: from(43.91 ±3.85)% to(29.76 ±2.49)%; 48h: from(66.09±1.67)% to(59.88±3.43)%]. ·CONCLUSION: Concentrations of IGFBP-6 increased in the vitreous,serum,and retinas only in advanced PVR in vivo. IGFBP-6 also inhibited IGF-II-induced cell proliferation in a not dose or time dependent manner and migration. IGFBP-6 participates in the development of PVR and might play a protective role in PVR.

关键词： insulin-like growth factor binding protein-6 proliferative vitreoretinopathy retinal pigment epithelial cells

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Nomogram for predicting non-proliferative vitreoretinopathy probability after vitrectomy in eyes with rhegmatogenous retinal detachment

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 215-223页

作者： Zhi-Qiang Gao Pei-Yu Wu Jing Zhang Zhi-Sheng Ke Xu-Ting Hu Zhao-Liang Zhang Jing-Wei Zheng Zong-Duan Zhang Qin-Tuo Pan Department of Ophthalmology the Third People’s Hospital of Yuhang DistrictHangzhou 311115Zhejiang ProvinceChina Department of Fundus Surgery Eye Hospital and School of Ophthalmology and OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmic Clinic Eye Hospital and School of Ophthalmology and OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of Gastroenterology the First People’s Hospital of Linping DistrictHangzhou 311100Zhejiang ProvinceChina

AIM:To identify the risk factors for postoperative proliferative vitreoretinopathy(PVR)in patients with primary rhegmatogenous retinal detachment(RRD)and develop a nomogram for predicting postoperative PVR-free ***:A total of 741 patients(741 eyes)diagnosed with primary RRD who underwent first surgery in the same hospital were retrospectively reviewed and randomly assigned with 521 to the training set and 220 to the validation *** and multivariate logistic regression analyses were performed in the training cohort to determine risk factors to construct a nomogram for predicting the 3-,4-,5-,and 6-month postoperative PVR-free *** performance was estimated by the concordance index(C-index),calibration plot,and the area receiver operating characteristic(ROC)***:A nomogram was constructed based on the preoperative PVR,silicone oil tamponade time(SOTT),photocoagulation energy(PE),retinal tear size(RTS),and *** the training set,the C-index of the nomogram was 0.896,0.936,0.961,and 0.972 at 3,4,5,and 6mo,*** C-index values in the validation set were 0.860,0.936,0.951,and 0.965 at 3,4,5,and 6mo,***-curve analysis indicated that only the 4-,5-,and 6-month nomograms had significant net benefits over a large threshold probabilities ***:Preoperative PVR,SOTT,PE,RTS,and hypertension are significant risk factors for postoperative PVR formation in patients with primary *** proposed nomogram can effectively predict the 4-,5-,and 6-month PVR-free probabilities after surgery and assist in making clinical decisions during follow-up.

关键词： nomogram proliferative vitreoretinopathy rhegmatogenous retinal detachment risk factor

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Intravitreal slow-release dexamethasone alleviates traumatic proliferative vitreoretinopathy by inhibiting persistent inflammation and Müller cell gliosis in rabbits

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 22-32页

作者： Yi-Ming Zhao Rong-Sha Sun Fang Duan Fang-Yu Wang Yu-Jie Li Xiao-Bing Qian Jie-Ting Zeng Yao Yang Xiao-Feng Lin State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina Xi’an People’s Hospital(Xi’an Fourth Hospital) Shaanxi Eye HospitalXi’an 710004Shaanxi ProvinceChina

AIM:To evaluate the effects of intravitreal slow-release dexamethasone on traumatic proliferative vitreoretinopathy(PVR)and Müller cell gliosis and preliminarily explored the possible inflammatory mechanism in a rabbit model induced by penetrating ocular ***:Traumatic PVR was induced in the right eyes of pigmented rabbits by performing an 8-mm circumferential scleral incision placed 2.5 mm behind the limbus,followed by treatment with a slow-release dexamethasone implant(Ozurdex)or sham *** eyes were used as normal *** intraocular pressure(IOP)was monitored using an iCare *** severity was evaluated via anatomical and histopathological examinations every week for 6wk;specific inflammatory cytokine and proliferative marker levels were measured by quantitative real-time polymerase chain reaction,Western blot,protein chip analysis,or immunofluorescence ***:During the observation period,PVR severity gradually *** Müller cell gliosis was observed in the peripheral retina near the wound and in the whole retina of PVR *** significantly alleviated PVR development and Müller cell ***-traumatic inflammation fluctuated and was *** interleukin-1β(IL-1β)mRNA level was significantly upregulated,peaking on day 3 and increasing again on day 21 after *** expression of nod-like receptor family pyrin domain containing 3(NLRP3)showed a similar trend that began earlier than that of IL-1β*** suppressed the expression of IL-1β,NLRP3,and phosphorylated nuclear factor-kappa B(NF-κB).The average IOP after treatment was within normal ***:The present study demonstrates chronic and fluctuating inflammation in a traumatic PVR rabbit model over *** treatment significantly inhibites inflammatory cytokines expression and Müller cell gliosis,and thus alleviates PVR *** study highlights the important role of IL-1β,and Ozurdex inhibites inflammation pres

关键词： ocular trauma proliferative vitreoretinopathy gliosis Ozurdex inflammation rabbit

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Upregulation of ASPP2 expression alleviates the development of proliferative vitreoretinopathy in a rat model

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1813-1819页

作者： Yan-Kun Yue Xiao-Li Chen Shan Liu Wu Liu Department of Ophthalmology Fuxing HospitalCapital Medical UniversityBeijing 100038China Department of Ophthalmology Beijing TongRen HospitalCapital Medical UniversityBeijing 100730China

AIM:To investigate whether upregulation of apoptosisstimulating p53 protein 2(ASPP2)expression could alleviate the development of proliferative vitreoretinopathy(PVR)in a rat ***:ASPP2-lentivirus or scrambled-lentivirus were transfected into ARPE-19 cells,followed with measurements of cell cytotoxicity by cell counting kit-8 ***2 upregulation was confirmed by Western blotting and *** ARPE-19 cells pretreated with ASPP2-lentivirus were intravitreally injected to Brown Norway rats to induce PVR *** development and retinal function were evaluated by retinal photography and electroretinography,***,epithelial-mesenchymal transition as well as autophagy were investigated in rats’retinas via Western ***:Protein expression of ASPP2 was significantly upregulated by ASPP2-lentivirus transfection in ARPE-19 *** development and progression of PVR were impeded significantly in rats with intravitreal injection of ARPE-19 cells pretreated with ***,retinal functions were less affected and PVR grades were much lower in rats with ASPP2-lentivirus compared to scrambledlentivirus ***,epithelial-mesenchymal transition and autophagy markers were decreased in the retinas of rats treated with ***:ASPP2-lentivirus transfected to ARPE-19 cells mitigates the progression of PVR in rat models,which might be partly through reduced autophagy and attenuated epithelial-mesenchymal ***2 might stand as a new approach for PVR treatment in the future.

关键词： proliferative vitreoretinopathy apoptosisstimulating p53 protein 2 epithelial–mesenchymal transition autophagy ARPE-19

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Outcomes and predictors of vitrectomy and silicone oil tamponade in retinal detachments complicated by proliferative vitreoretinopathy

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1279-1289页

作者： Kenan Sonmez Hilal Kilinc Hekimsoy University of Health Sciences Ulucanlar Eye Education and Research HospitalAnkara 06240Turkey

AIM:To evaluate outcomes and determine factors influencing the outcomes of vitrectomy with silicone oil(SO)endotamponade for the management of rhegmatogenous retinal detachment(RRD)complicated by advanced proliferative vitreoretinopathy(PVR).METHODS:This is a retrospective,interventional case series of eyes with PVR grade C associated RRD with or without prior surgery that underwent vitreoretinal surgery and SO *** with a minimum follow-up of 6mo after SO extraction were *** were classified into three PVR subgroups according to severity and extension of *** influence of several preoperative,intraoperative and postoperative factors upon the functional and anatomical outcomes was assessed using multivariate logistic regression ***:A hundred and one eyes of 101 patients that met the inclusion criteria were ***-five of 101 eyes(74.3%)had successful retinal reattachment after one *** aqueous cell and flare at the first week exam had a statistically significant association with redetachment,recurrent membrane proliferation and *** acuity improvement was significantly associated with faint postoperative aqueous inflammation values,primary vitrectomy and PVR outside of the posterior ***:Although encouraging anatomical and functional outcomes are achieved after vitrectomy and SO tamponade in eyes with RRD complicated by PVR,an increase in aqueous flare or cells at the first week follow-up is most likely to result in postoperative late *** vitrectomy,PVR associated with minimal posterior pole extension and absent to mild postoperative aqueous inflammation are associated with improved post-operative final visual acuity.

关键词： proliferative vitreoretinopathy aqueous inflammation silicone oil tamponade vitrectomy predictors

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Emerging roles of circular RNAs in retinal diseases

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Neural Regeneration Research 2022年第9期17卷 1875-1880页

作者： Aneliya Hanineva Karen Sophia Park Joshua J.Wang Margaret M.DeAngelis Michael H.Farkas Sarah X.Zhang Department of Ophthalmology and Ross Eye Institute Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloState University of New YorkBuffaloNYUSA Research Service Veterans Administration Western New York Healthcare SystemBuffaloNYUSA Department of Biochemistry Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloState University of New YorkBuffaloNYUSA

Retinal disorders are a group of ocular diseases whose onset is associated with a number of aberrant molecular and cellular processes or physical damages that affect retinal structure and function resulting in neural and vascular degeneration in the *** research has primarily focused on delaying retinal disease with minimal success in preventing or reversing neuronal *** this review,we explore a relatively new field of research involving circular RNAs,whose potential roles as biomarkers and mediators of retinal disease pathogenesis have only just *** knowledge of circular RNAs function is limited given its novelty,current evidence has highlighted their roles as modulators of microRNAs,regulators of gene transcription,and biomarkers of disease development and ***,we summarize how circular RNAs may be implicated in the pathogenesis of common retinal diseases including diabetic retinopathy,glaucoma,proliferative vitreoretinopathy,and age-related macular ***,we explore the potential of circular RNAs as novel biomarkers and therapeutic targets for the diagnosis and treatment of retinal diseases.

关键词： age-related macular degeneration circular RNA diabetic retinopathy glaucoma microRNA proliferative vitreoretinopathy retina

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The role of mechanical stretch and TGF-β2 in epithelial-mesenchymal transition of retinal pigment epithelial cells

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International Journal of Ophthalmology(English edition) 2019年第12期12卷 1832-1838页

作者： Qian Cao Qu-Zhen Deji Ya-Jun Liu Wei Ye Wang-Dui Zhaba Qin Jiang Feng Yan Eye Hospital Nanjing Medical UniversityNanjing 210002Jiangsu ProvinceChina The Fourth School of Clinical Medicine Nanjing Medical UniversityNanjing 210002Jiangsu ProvinceChina Affiliated Jinling Hospital Medical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Departm ent of Ophthalm ology N anjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina School of Second Military Medical University Department of OphthalmologyJinling HospitalNanjing 210002Jiangsu ProvinceChina

AIM: To explore the effects and mechanisms of mechanical stress and transforming growth factor-beta2(TGF-β2) on epithelial-mesenchymal transition(EMT) in cultured human retinal pigment epithelial(RPE) cells. METHODS: Human RPE cells were inoculated on BioF ex 6-well plates and RPE cells received 0, 1, 2, 3, or 4 mild stretch injuries delivered 3h apart after 24h of culture. The device of mechanical stress parameters were set to sine wave, frequency 1 Hz, stretch strength 20%. For treatment with TGF-β2, when the inoculated RPE cells in 6-well plates were around 60% confluent, serum was reduced to 0 for 12h and recombinant human TGF-β2(0, 1, 5, 10 ng/mL)was added for 48h. α-SMA, Vimentin and N-Cadherin, fibronectin proteins expressions were detected by Western blotting, confocal cell immunofluorescence and quantitative real-time polymerase chain reaction(q RT-PCR). Then we detected the change of mi RNA-29b and ascertained the changes of phosphatidylinositol 3-kinase-serine threonine protein kinase(PI3K/Akt) pathway after RPE cells were stretched by the device of mechanical stress and induced by TGF-β2 by Western blotting, confocal cell immunofluorescence and qR T-PCR. RESULTS: Mechanical stress induce EMT and activate the PI3K/Akt pathway in ways that lead to the EMT process. TGF-β2 induce RPE cells EMT and in a certain range and TGF-β2 decrease the miR NA-29b expression in RPE cells, and the inhibitory effect is more obvious with the increase of TGF-β2 concentration. CONCLUSION: Our findings are crucial steps in determining the critical roles of the PI3K/Akt signaling pathway and mi RNA-29b in pathogenesis of proliferative vitreoretinopathy(PVR) which may be a potential target for preventing or treating PVR.

关键词： mechanical stress transforming growth factor-beta2 microRNA 29b epithelial-mesenchymal transition phosphatidylinositol 3-kinase-serine threonine protein kinase pathway proliferative vitreoretinopathy

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Artesunate inhibits proliferation and migration of RPE cells and TGF-β2 mediated epithelial mesenchymal transition by suppressing PI3K/AKT pathway

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 197-204页

作者： Zi-Yi Wang Yu Zhang Ling-Dan Wu Jie Chen Mei-Ling Chen Ci-Min Chen Qi-Hua Xu The Affiliated Eye Hospital of Nanchang University Jiangxi Clinical Research Center for Ophthalmic DiseaseNanchang 330000Jiangxi ProvinceChina

AIM:To study the braking effectiveness of artesunate on transforming growth factor(TGF)-β2 mediated epithelial-mesenchymal transition(EMT)in retinal pigment epithelium(RPE)in ***:The fostered ARPE-19 cells were processed with artesunate alone or combined with the TGF-β*** CCK-8 examination was utilized to test the cell *** migration was detected by scratch as well as the Transwell *** EMT characters and activation of PI3K/Akt signal channel were estimated by Western blotting and *** Western blotting was utilized in order to confirm the vitreous of controls as well as patients with proliferative vitreoretinopathy(PVR)were collected and the levels of PI3K,phospho-PI3K,***:Disposal of ARPE-19 cells with artesunate(50-150μmol/L)obviously suppressed their propagation and immigration,which dependent on the concentration and *** suppressed the EMT which was induced by TGF-β2 in ARPE-19 cells through sustaining the expression of vimentin andα-SMA through the suppression of PI3K,phospho-PI3K,phospho-Akt and *** of PI3K,phospho-PI3K,AKT and phospho-Akt was increased in the vitreous in PVR(P<0.05).CONCLUSION:Such findings indicate that PI3K/Akt signal channel is highly activated in vitreous of *** is an operative depressor of the propagation,immigration and TGF-β2-mediated EMT of ARPE-19 cells by reduced the expression of PI3K/Akt channel.

关键词： proliferative vitreoretinopathy artesunate epithelial-mesenchymal transition migration

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Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-β in ARPE-19

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 8-14页

作者： Jing Zhu Duy Nguyen Hong Ouyang Xiao-Hui Zhang Xiao-Ming Chen Kang Zhang Department of Ophthalmology West China Hospital Sichuan University Department of Ophthalmology and Shiley Eye Center and Institute for Genomic MedicineUniversity of California San Diego Beijing Institute of Ophthalmology Beijing Tongren Eye CenterCapital Medical University

AIM:To investigate the role of Rho-associated protein kinase (ROCK) inhibitor, Y27632, in mediating the production of extracellular matrix (ECM) components including fibronectin, matrix metallo-proteinase-2 (MMP-2) and type I collagen as induced by connective tissue growth factor(CTGF) or transforming growth factor-β (TGF-β) in a human retinal pigment epithelial cell line, ARPE-19. METHODS:The effect of Y27632 on the CTGF or TGF-β induced phenotype in ARPE-19 cells was measured with immunocytochemistry as the change in F-actin. ARPE-19 cells were treated with CTGF (1, 10, 100ng/mL)and TGF-β (10ng/mL) in serum free media, and analyzed for fibronectin, laminin, and MMP-2 and type I collagen by RT-qPCR and immunocytochemistry. Cells were also pretreated with an ROCK inhibitor, Y27632, to analyze the signaling contributing to ECM production. ·RESULTS:Treatment of ARPE-19 cells in culture with TGF-β or CTGF induced an ECM change from a cobblestone morphology to a more elongated swirl pattern indicating a mesenchymal phenotype. RT-qPCR analysis and different gene expression analysis demonstrated an upregulation in expression of genes associated with cytoskeletal structure and motility. CTGFor TGF-β significantly increased expression of fibronectin mRNA (P =0.006, P =0.003 respectively), laminin mRNA (P =0.006, P =0.005), MMP-2 mRNA (P =0.006, P =0.001), COL1A1 mRNA (P =0.001, P =0.001), COL1A2 mRNA (P = 0.001, P =0.001). Preincubation of ARPE-19 with Y27632 (10mmol/L) significantly prevented CTGF or TGF-β induced fibronectin (P=0.005, P=0.003 respectively), MMP-2 (P = 0.003, P =0.002), COL1A1 (P =0.006, P =0.003), and COL1A2 (P =0.006, P =0.004) gene expression, but not laminin (P =0.375, P =0.516). CONCLUSION:Our study demonstrated that both TGF-β and CTGF upregulate the expression of ECM components including fibronectin, laminin, MMP-2 and type I collagen by activating the RhoA/ROCK signaling pathway. During this process, ARPE-19 cells were shown to change from an epith

关键词： Rho-associated protein kinase inhibitor Connective tissue growth factor transforming growth factor-β proliferative vitreoretinopathy

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