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The Importance of Prolactin levels in Patients Treated with Cabergoline for the Prevention of OHSS:Is Cabergoline Really Effective in Patients with High Risk of OHSS?

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Open Journal of Obstetrics and Gynecology 2015年第6期5卷 344-349页

作者： Serkan Oral Yasam Kemal Akpak Nilay Karaca Kadir Savan Department of Assisted Reproduction LIV HospitalIstanbulTurkey Department of Obstetrics and Gynecology Ankara Mevki Military HospitalAnkaraTurkey Department of Obstetrics and Gynecology Bezmi Alem Vakif University HospitalIstanbulTurkey Department of Assisted Reproduction Bahcelievler Medicalpark HospitalIstanbulTurkey

Background: OHSS is a dangerous and potentially life-threatening condition for which many researchers look for new ways to treat. Aim: To determine the effectiveness of prophylactic cabergoline administration on prolactine levels in patients with high risk for ovarian hyperstimulation syndrome (OHSS). Material and Methods: 163 in vitro fertilisation (IVF) patients with high risk for OHSS were enrolled in the study. The criteria for inclusion were more than 15 oocytes retrieved at oocyte pick up. A standard antagonist protocol was used for ovulation induction. Cabergoline treatments (0.5 mg/day) were started on the day of oocyte retrieval and continued for eight days. prolactine levels were measured at the day of oocyte retrieval and the 9th day after the oocyte retrieval. Results: Of the 163 patients, 26 (15.9%) had OHSS. prolactine levels on the day of oocyte retrieval were 44.22 ± 24.78 ng/mL and 37.6 ± 22.5 ng/mL in patients with OHSS and without OHSS, respectively (P > 0.05). In contrary prolactine levels were significantly higher in patients with OHSS patients (3.9 ± 5.07 ng/mL) than in patients without OHSS (2.1 ± 2.92 ng/mL) at the 9th day after oocyte retrieval (P prolactine levels were higher in patients with OHSS than without OHSS who were treated with cabergoline for the prevention of OHSS.

关键词： Cabergoline Ovarian Hyperstimulation Syndrome(OHSS) prolactine levels In Vitro Fertilization(IVF) Vascular Endothelial Growth Factor(VEGF)

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