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Treatment of pediatric Ogilvie’s syndrome with low-dose erythromycin:A case report

World Journal of Gastroenterology 2007年第13期13卷 2002-2003页

作者： Da-Peng Jiang Zhao-Zhu Li Sheng-Yang Guan Yu-Bo Zhang Department of Pediatric Surgery Second AffiliatedHospital of Harbin Medical University Harbin 150086Heilongjiang Province China

Acute colonic pseudo-obstruction is a poorly understood syndrome, characterized by the signs, symptoms and radiological pattern of a large bowel obstruction without evidence for a mechanical obstruction. We report a case of a 2-year old boy who presented with progressive abdominal distention, vomiting and abdominal pain on postoperative d 3. Plain abdominal X-ray showed markedly dilated large bowel. Mechanical colonic obstruction was ruled out with hypaque enema. Ogilvie＇s syndrome was suspected. The patient received treatment with oral erythromycin which had an immediate beneficial effect. During the 6 mo follow-up, no recurrences of symptoms were observed. We provide a safe and effective therapy for Ogilvie＇s syndrome in pediatric individuals.

关键词： Acute colonic pseudo-obstruction Erythromycin Abdominal distention prokinetic agent

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Current developments in pharmacological therapeutics for chronic constipation

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Acta Pharmaceutica Sinica B 2015年第4期5卷 300-309页

作者： Chunhuan Jiang Qinglong Xu Xiaoan Wen Hongbin Sun State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease China Pharmaceutical University

Chronic constipation is a common gastrointestinal disease severely affecting the patient's quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic constipation. However, a significant unmet medical need still remains, particularly among those patients achieving poor results by current therapies. The 5-EF1'1 receptor modulators velusetrag and naronapride, the guanylate cy-clase C agonist plecanatide and die deal bile acid transporter inhibitor elobixibat are recognized as the most promising drugs under investigation. Herein, we give a comprehensive review on the pharmacological therapeutics for the treatment of chronic constipation, with the purpose of reflecting the drug development trends in this field. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://***/by-ne-rid/4.0/).

关键词： Chronic constipation prokinetic agent 5-HT1 receptor Prosecretory agent

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Lubiprostone:Clinical applications beyond constipation

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World Journal of Gastroenterology 2009年第9期15卷 1147-1147页

作者： Shailendra Kapoor Kristin 24 SchaumburgIL 60195 United States

In comparison to polyethylene glycol,lubiprostone offers other advantages and is increasingly being used as an adjunctive agent in diagnostic as well as management strategies not only in gastroenterology, but in other *** instance,lubiprostone exerts beneficial effects in cystic fibrosis *** augmernts the chloride secretion in these cells by activating non-cystic fibrosis transmembrane regulator(CFTR) secretion of chloride by afflicted respiratory epithelia. Lubiprostone also seems to improve visualization of the gastrointestinal tract during procedures such as *** is especially true if the lubiprostone is administered prior to bowel cleansing with agents such as polyethylene glycol electrolyte(PEG-E). Lubiprostone also enhances and stimulates contraction in colonic as well as gastric muscles and may thus further contribute as a prokinetic *** these effects,lubiprostone also causes hyperpolarization in other tissues such as uterine muscle *** may prove to be of significant clinical benefit in the management of uterine pathologies in the near future.

关键词： Lubiprostone Cystic fibrosis Colonoscopy Uterine muscle prokinetic agent

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